In order to make the classification and regression of single-stage detectors more accurate, an object detection algorithm named Global Context You-Only-Look-Once v3 (GC-YOLOv3) is proposed based on the You-Only-Look-Once (YOLO) in this paper. Firstly, a better cascading model with learnable semantic fusion between a feature extraction network and a feature pyramid network is designed to improve detection accuracy using a global context block. Secondly, the information to be retained is screened by combining three different scaling feature maps together. Finally, a global self-attention mechanism is used to highlight the useful information of feature maps while suppressing irrelevant information. Experiments show that our GC-YOLOv3 reaches a maximum of 55.5 object detection mean Average Precision (mAP)@0.5 on Common Objects in Context (COCO) 2017 test-dev and that the mAP is 5.1% higher than that of the YOLOv3 algorithm on Pascal Visual Object Classes (PASCAL VOC) 2007 test set. Therefore, experiments indicate that the proposed GC-YOLOv3 model exhibits optimal performance on the PASCAL VOC and COCO datasets.

In the medical field, Alzheimer’s disease (AD), as a neurodegenerative brain disease which is very difficult to diagnose, can cause cognitive impairment and memory decline. Many existing works include a variety of clinical neurological and psychological examinations, especially computer-aided diagnosis (CAD) methods based on electroencephalographic (EEG) recording or MRI images by using machine learning (ML) combined with different preprocessing steps such as hippocampus shape analysis, fusion of embedded features, and so on, where EEG dataset used for AD diagnosis is usually is large and complex, requiring extraction of a series of features like entropy features, spectral feature, etc., and it has seldom been applied in the AD detection based on deep learning (DL), while MRI images were suitable for both ML and DL. In terms of the structural MRI brain images, few differences could be found in brain atrophy among the three situations: AD, mild cognitive impairment (MCI), and Normal Control (NC). On the other hand, DL methods have been used to diagnose AD incorporating MRI images in recent years, but there have not yet been many selective models with very deep layers. In this article, the Gray Matter (GM) Magnetic Resonance Imaging (MRI) is automatically extracted, which could better distinguish among the three types of situations like AD, MCI, and NC, compared with Cerebro Spinal Fluid (CSF) and White Matter (WM). Firstly, FMRIB Software Library (FSL) software is utilized for batch processing to remove the skull, cerebellum and register the heterogeneous images, and the SPM + cat12 tool kits in MATLAB is used to segment MRI images for obtaining the standard GM MRI images. Next, the GM MRI images are trained by some new neural networks. The characteristics of the training process are as follows: (1) The Tresnet, as the network that achieves the best classification effect among several new networks in the experiment, is selected as the basic network. (2) A multi-receptive-field mechanism is integrated into the network, which is inspired by neurons that can dynamically adjust the receptive fields according to different stimuli. (3) The whole network is realized by adding multiple channels to the convolutional layer, and the size of the convolution kernel of each channel can be dynamically adjusted. (4) Transfer learning method is used to train the model for speeding up the learning and optimizing the learning efficiency. Finally, we achieve the accuracies of 86.9% for AD vs. NC, 63.2% for AD vs. MCI vs. NC respectively, which outperform the previous approaches. The results demonstrate the effectiveness of our approach.