Jingwen Zhang is mainly focus on cardiovascular sciences and molecular biology to understand the molecular mechanisms of age-related cardiovascular disease, especially coronary artery disease (CAD). Jingwen Zhang studies the signaling mechanisms underlying the reduced tolerance in elderly patients' hearts to stress caused by restricted blood flow (ischemia) and the restoration of normal blood flow (reperfusion). The goal is to reveal the molecular mechanisms involved in metabolism and inflammation regulation in responsible for the longevity sensor Sirtuins (especially Sirtuin1 and Sirtuin3) and develop appropriate therapeutic approaches to prevent and treat myocardial ischemia, hypertension, cardiac hypertrophy, and diabetes.