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Ângela R. Guerra
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Representative Publications
View All Publications19 September 2018 in Journal of Agricultural and Food Chemistry
Journal Article
21 August 2013 in Journal of Agricultural and Food Chemistry
Journal Article
PRPatricia Ramos
Patricia RamosÂGÂngela R. Guerra
Ângela R. GuerraOGOlinda Guerreiro
Olinda Guerreiro
Carmen Freire
Artur M. S. Silva
Armando Silvestre +1
1 November 2014 in Industrial Crops and Products
Journal Article
PRPatricia Ramos
Patricia Ramos
Sonia SantosÂGÂngela R. Guerra
Ângela R. GuerraOGOlinda Guerreiro
Olinda GuerreiroCarmen FreireArmando Silvestre +2
1 April 2013 in Industrial Crops and Products
Journal Article
PRPatricia Ramos
Patricia RamosSonia SantosÂGÂngela R. Guerra
Ângela R. GuerraOGOlinda Guerreiro
Olinda GuerreiroLFLaura Felício
Laura Felício
Maria F. Duarte +3
10 May 2012 in Industrial & Engineering Chemistry Research
Journal Article
IMInês Mota
Inês Mota
PPPaula Pinto
Paula PintoCNCatarina Cardoso Novo
Catarina Cardoso NovoGSGabriel Sousa
Gabriel Sousa
OGOlinda Guerreiro
Olinda Guerreiro
Alírio Rodrigues +2
16 September 2014 in Mini-Reviews in Organic Chemistry
Journal Article
RDRui M.A. Domingues
Rui M.A. DominguesÂGÂngela R. Guerra
Ângela R. GuerraMaria F. DuarteCarmen FreireCNCarlos P. Neto
Carlos P. Neto
Armando Silvestre +1
This review aims to provide an overview of the biogenetic origin of triterpenic acids (with particular emphasis on ursolic, oleanolic and betulinic acids), on the analytical extraction and hyphenated methodologies (mainly GC-MS) used on their identification and quantification, followed by an overview of the major sources of these components, indicating their potential large scale production pathways, with especial emphasis on abundant agroforestry biomass residues. The biological activity of ursolic, oleanolic and betulinic acids is described, focusing on their antitumoral potential as modulators of growth inhibitory signals, evasion of apoptosis and angiogenesis. The future perspectives towards improved therapeutic strategies using these triterpenic acids are also herein discussed.
About Me
A. Guerra initiated her scientific activity in 2008, as trainee at the Toxicology and Pharmacology Laboratory
of Universidade de Évora in the context of Biochemistry degree. During her master’s degree, she
investigated the anti-tumoral activity of Cynara cardunculus extracts in the PI3K/AKT/mTOR signaling
pathway. In recent years, A. Guerra has worked under the projects "Biological characterization of E. grandis
x globulus bark lipophilic extractives on human breast cancer cell lines" (within the European Project
AFORE (FP7) coordinated by VTT; and "NEucbark - New Valorization Strategies for Eucalyptus spp. Bark
Extracts Eucalyptus triterpenic biological activity" (PTDC/AGR-FOR/3187/2012). Recently finished
her PhD work, supported by FCT (SFRH/BD/98635/2013), on “Metabolomics study of the effects of
eucalyptus bark compounds on human breast cancer and non-tumor epithelial cells”, under the scientific
supervision of Dr. Iola Duarte (CICECO/UA) and Dr. Fátima Duarte (CEBAL/ICAAM).