Prof. Walid Hleihel
Holy Spirit University of Kaslik
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Academic Career Length
26Years (2001-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 April 2018 in Journal of Pharmaceutical and Biomedical Analysis
Journal Article
TBTania Bitar
Tania BitarSMSylvie Mavel
Sylvie MavelPEPatrick Emond
Patrick EmondLNLydie Nadal-Desbarats
Lydie Nadal-DesbaratsALAntoine Lefèvre
Antoine LefèvreCAChristian R - Pr Christian Andres
Christian R - Pr Christian Andres +5
1 December 2017 in Public Health
Journal Article
Journal Article
MRMelissa Michel Roufael
Melissa Michel RoufaelTBTania Bitar
Tania BitarYSYONNA C SACRE
YONNA C SACRECAChristian R - Pr Christian Andres
Christian R - Pr Christian AndresWalid HleihelAutism Spectrum Disorder (ASD) has become a major public health concern due to its rapidly rising incidence over the past few years. Disturbances in folate or methionine metabolism have been identified in many individuals with ASD, suggesting that the folate–methionine cycle may play an essential role in the pathogenesis of autism. Thus, changes in metabolite concentrations associated with this cycle could be used as potential biomarkers and therapeutic targets for ASD. The aim of this systematic review is to elucidate the perturbations of this cycle and the possible interventions that may be proposed in this context. Several studies have shown that high levels of homocysteine and low levels of vitamins B12 and folate are associated with ASD. These changes in serum metabolites are influenced by poor diet. In fact, children with ASD tend to eat selectively, which could compromise the quality of their diet and result in nutrient deficiencies. Moreover, these disturbances may also be caused by genetic predispositions such as polymorphisms of the MTHFR gene. Few studies have demonstrated the beneficial effects of the use of nutritional supplements in treating ASD children. Therefore, larger, well-structured studies are recommended to examine the impact of vitamin B12 and folate supplementation on homocysteine levels.
Journal Article
INImad Abrao Nemeir
Imad Abrao NemeirJSJoseph Saab
Joseph SaabWalid Hleihel
Abdelhamid ERRACHID
Nicole Jaffrezic-RenaultINImad Abrao Nemeir
Imad Abrao NemeirBreast Cancer is one of the world’s most notorious diseases affecting two million women in 2018 worldwide. It is a highly heterogeneous disease, making it difficult to treat. However, its linear progression makes it a candidate for early screening programs, and the earlier its detection the higher the chance of recovery. However, one key hurdle for breast cancer screening is the fact that most screening techniques are expensive, time-consuming, and cumbersome, making them impractical for use in several parts of the world. One current trend in breast cancer detection has pointed to a possible solution, the use of salivary breast cancer biomarkers. Saliva is an attractive medium for diagnosis because it is readily available in large quantities, easy to obtain at low cost, and contains all the biomarkers present in blood, albeit in lower quantities. Affinity sensors are devices that detect molecules through their interactions with biological recognition molecules. Their low cost, high sensitivity, and selectivity, as well as rapid detection time make them an attractive alternative to traditional means of detection. In this review article, we discuss the current status of breast cancer diagnosis, its salivary biomarkers, as well as the current trends in the development of affinity sensors for their detection.
Journal Article
Skeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that are maintained in a quiescent state in homeostatic conditions. Skeletal muscle is remarkable in its ability to adapt to mechanical constraints, a property referred as muscle plasticity and mediated by both MCPs and myofibers. An emerging body of literature supports the notion that muscle plasticity is critically dependent upon nuclear mechanotransduction, which is transduction of exterior physical forces into the nucleus to generate a biological response. Mechanical loading induces nuclear deformation, changes in the nuclear lamina organization, chromatin condensation state, and cell signaling, which ultimately impacts myogenic cell fate decisions. This review summarizes contemporary insights into the mechanisms underlying nuclear force transmission in MCPs and myofibers. We discuss how the cytoskeleton and nuclear reorganizations during myogenic differentiation may affect force transmission and nuclear mechanotransduction. We also discuss how to apply these findings in the context of muscular disorders. Finally, we highlight current gaps in knowledge and opportunities for further research in the field.
1 April 2017 in Experimental and Toxicologic Pathology
Journal Article
SSSaly Sawan
Saly Sawan
TYTania Yaacoub
Tania Yaacoub
SHSouad Hraoui-Bloquet
Souad Hraoui-Bloquet
RSRiyad Sadek
Riyad Sadek
Walid HleihelMKMarc Karam
Marc Karam +1
About Me
I am the current Associate Dean for Research and Doctoral studies of the Faculty of Arts and Sciences, current Associate Dean for Administrative Affairs of the Faculty of Medicine, former Dean of the Faculty of Sciences, former Deputy President for Students Academic Affairs, former President of the Admissions Committee at the Holy Spirit University of Kaslik (USEK) in Lebanon.
I received my PhD in Physiology from Nantes University in France in 2002, while I was working on the calcium regulation in the skeletal and cardiac muscles at The French National Council of Research. I was awarded the Professional Educator Certificate from the UT Global Initiative for Education and Leadership of the University of Texas at Austin. I am currently teaching at the faculties of Sciences, Medicine and Engineering at USEK, and my research interests focus on Autism Spectrum Disorder in Lebanon. At the present I am working on investigating the causes of this pathology. My activities include the development of a new nanobioanalytical platform for detecting and monitoring cancer biomarkers in saliva and the characterization of the venom of a Lebanese Viper. I am part of a European research project “Neuren” and have previously been involved in several Tempus academic and administrative projects. I have been also actively participating in various international conferences and trainings on teaching and learning.