Using multi-omics, molecular and biochemical analyses, I study the effet of psychobiotics on brain functions of mammals and investigate the molecular basis of brain diseases (i.e., Autism, PD & Prion infectious dieases). I also study the function of ADAMTS-18 and use hibernating mammals as a model to learn extreme metabolic regulation and adaptive evolution (https://www.researchgate.net/profile/Yi-Hsuan_Pan). Research projects: 1. Psycobiotics, Brain function and diseases: Autism, PD & Prion infectious diseases. 2. Molecular ecology and evolution 3. Regulation of blood glucose level in type 2 diabetes (FDA IND 145464). 4. Physiological functions of ADAMTS-18