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Background. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected >160 million people around the world. Hypertension (HT), chronic heart disease (CHD), and diabetes mellitus (DM) increase susceptibility to SARS-CoV-2 infection. Aims. We designed this retrospective study to assess the gender differences in hypertensive diabetic SARS-CoV-2 patients. We reported data, by gender differences, on the inflammatory status, on the hospital stays, intensive care unit (ICU) admission, Rx and CT report, and therapy. Methods. We enrolled 1014 patients with confirmed COVID-19 admitted into different Hospitals of Campania from 26 March to 30 June, 2020. All patients were allocated into two groups: diabetic-hypertensive group (DM-HT group) that includes 556 patients affected by diabetes mellitus and arterial hypertension and the non-diabetic- non-hypertensive group (non-DM, non-HT group) comprising 458 patients. The clinical outcomes (i.e., discharges, mortality, length of stay, therapy, and admission to intensive care) were monitored up to June 30, 2020. Results. We described, in the DM-HT group, higher proportion of cardiopathy ischemic (CHD) (47.5% vs. 14.8%, respectively; p< 0.0001) and lung diseases in females compared to male subjects (34.8% vs. 18.5%, respectively; p< 0.0001). In male subjects, we observed higher proportion of kidney diseases (CKD) (11% vs. 0.01%, respectively; p< 0.0001), a higher hospital stay compared to female subjects (22 days vs. 17 days, respectively, p< 0.0001), a higher admission in ICU (66.9% vs. 12.8%, respectively, p< 0.0001), and higher death rate (17.3% vs. 10.7%, respectively, p< 0.0001). Conclusion. These data confirm that male subjects, compared to female subjects, have a higher hospital stay, a higher admission to ICU, and higher death rate.
Tiziana Ciarambino; Filippina Ciaburri; Venere Delli Paoli; Giuseppe Caruso; Mauro Giordano; Maria D’Avino. Arterial Hypertension and Diabetes Mellitus in COVID-19 Patients: What Is Known by Gender Differences? Journal of Clinical Medicine 2021, 10, 3740 .
AMA StyleTiziana Ciarambino, Filippina Ciaburri, Venere Delli Paoli, Giuseppe Caruso, Mauro Giordano, Maria D’Avino. Arterial Hypertension and Diabetes Mellitus in COVID-19 Patients: What Is Known by Gender Differences? Journal of Clinical Medicine. 2021; 10 (16):3740.
Chicago/Turabian StyleTiziana Ciarambino; Filippina Ciaburri; Venere Delli Paoli; Giuseppe Caruso; Mauro Giordano; Maria D’Avino. 2021. "Arterial Hypertension and Diabetes Mellitus in COVID-19 Patients: What Is Known by Gender Differences?" Journal of Clinical Medicine 10, no. 16: 3740.
Introduction. Viral infections during pregnancy have always been considered to cause complications and adverse events and birth defects during pregnancy. In particular, we do not have any therapeutic or preventive tools aimed at protecting the mother and fetus during the gestational period during pandemics. Methods. The studies were identified by using the PubMed database published until 30 April 2021. The search was performed by using the following keywords: viral infection, SARS-CoV-2, COVID-19, vaccine, pregnancy, gestational period, pandemics, vaccination, complication, adverse events, drugs. Results. It has been reported that viral infections are considered to cause complications and adverse events during pregnancy. In this regard, pregnancy is associated with higher mortality rates and complications during viral infections. In fact, maternal immunization represents a unique approach to protect newborns from several infectious diseases. Conclusion. European Board and College of Obstetrics and Gynecology (EBCOG) and International public health institutions (WHO, CDC) report the recommendations about the use of vaccines during pregnancy.
Tiziana Ciarambino; Pietro Crispino; Mauro Giordano. Viral Infection, COVID-19 in Pregnancy and Lactating Women: What Is Known? COVID 2021, 1, 230 -245.
AMA StyleTiziana Ciarambino, Pietro Crispino, Mauro Giordano. Viral Infection, COVID-19 in Pregnancy and Lactating Women: What Is Known? COVID. 2021; 1 (1):230-245.
Chicago/Turabian StyleTiziana Ciarambino; Pietro Crispino; Mauro Giordano. 2021. "Viral Infection, COVID-19 in Pregnancy and Lactating Women: What Is Known?" COVID 1, no. 1: 230-245.
Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by structural and functional alterations of the heart. Aims: The purpose of this narrative review is to focus on the most important cardiomyopathies and their epidemiology, diagnosis, and management. Methods: Clinical trials were identified by Pubmed until 30 March 2021. The search keywords were “cardiomyopathies, sudden cardiac arrest, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy, arrhythmogenic cardiomyopathy (ARCV), takotsubo syndrome”. Results: Hypertrophic cardiomyopathy (HCM) is the most common primary cardiomyopathy, with a prevalence of 1:500 persons. Dilated cardiomyopathy (DCM) has a prevalence of 1:2500 and is the leading indication for heart transplantation. Restrictive cardiomyopathy (RCM) is the least common of the major cardiomyopathies, representing 2% to 5% of cases. Arrhythmogenic cardiomyopathy (ARCV) is a pathology characterized by the substitution of the myocardium by fibrofatty tissue. Takotsubo cardiomyopathy is defined as an abrupt onset of left ventricular dysfunction in response to severe emotional or physiologic stress. Conclusion: In particular, it has been reported that HCM is the most important cause of sudden death on the athletic field in the United States. It is needless to say how important it is to know which changes in the heart due to physical activity are normal, and when they are pathological.
Tiziana Ciarambino; Giovanni Menna; Gennaro Sansone; Mauro Giordano. Cardiomyopathies: An Overview. International Journal of Molecular Sciences 2021, 22, 7722 .
AMA StyleTiziana Ciarambino, Giovanni Menna, Gennaro Sansone, Mauro Giordano. Cardiomyopathies: An Overview. International Journal of Molecular Sciences. 2021; 22 (14):7722.
Chicago/Turabian StyleTiziana Ciarambino; Giovanni Menna; Gennaro Sansone; Mauro Giordano. 2021. "Cardiomyopathies: An Overview." International Journal of Molecular Sciences 22, no. 14: 7722.
The aim was to evaluate whether intra-hospital mortality from ischemic stroke is different in female patients. Methods. Studies were found in PubMed, Web of Science. We excluded 119 records because they did not include relevant reports or data. Studies were eligible for inclusion if enrolled adult patients with ischemic stroke and if the odds ratio (OR) of intra-hospital mortality in females compared to males is provided. Three retrospective cohort studies were eligible for inclusion criteria and so were included in the analysis. Findings: the random effect model showed a pooled significant higher risk of intra-hospital mortality [OR 1.34 (95% confidence interval 1.04, 1.74), P=0.026] in the female group compared to the male group. Our systematic review shows that intra-hospital mortality was significantly higher in female subjects compared to male.
Tiziana Ciarambino; Orazio Valerio Giannico; Amalia Campanile; Antonella Fischetti; Elena Barabgelata; Imma Ambrosino; Ombretta Para; Cecilia Politi; Mauro Giordano. Gender differences in ischemic stroke intra-hospital mortality: a systematic review. Italian Journal of Medicine 2021, 15, 1 .
AMA StyleTiziana Ciarambino, Orazio Valerio Giannico, Amalia Campanile, Antonella Fischetti, Elena Barabgelata, Imma Ambrosino, Ombretta Para, Cecilia Politi, Mauro Giordano. Gender differences in ischemic stroke intra-hospital mortality: a systematic review. Italian Journal of Medicine. 2021; 15 (2):1.
Chicago/Turabian StyleTiziana Ciarambino; Orazio Valerio Giannico; Amalia Campanile; Antonella Fischetti; Elena Barabgelata; Imma Ambrosino; Ombretta Para; Cecilia Politi; Mauro Giordano. 2021. "Gender differences in ischemic stroke intra-hospital mortality: a systematic review." Italian Journal of Medicine 15, no. 2: 1.
Acute pancreatitis, the most frequent hospitalization reason in internal medicine ward among gastrointestinal diseases, is burdened by high mortality rate. The disease manifests mainly in a mild form, but about 20-30% patients have a severe progress that requires intensive care. Patients presenting with acute pancreatitis should be clinically evaluated for organ failure signs and symptoms. Stratifying patients in the first days from symptoms onset is essential to determine therapy and care setting. The aim of our study is to evaluate prognostic factors for acute pancreatitis patients, hospitalized in internal medicine wards, and moreover, understanding the role of various prognostic scores validated in intensive care setting in predicting in-hospital mortality and/or admission to intensive care unit. We conducted a retrospective study enrolling all patients with diagnosis of acute pancreatitis admitted took an internal medicine ward between January 2013 and May 2019. Adverse outcome was considered in-hospital mortality and/or admission to intensive care unit. In total, 146 patients (137 with positive outcome and 9 with adverse outcome) were enrolled. The median age was (67.89 ± 16.44), with a slight prevalence of male (55.1%) compared to female (44.9%). C protein reactive (p = 0.02), creatinine (p = 0.01), sodium (p = 0.05), and troponin I (p = 0.013) after 48 h were significantly increased in patients with adverse outcome. In our study, progression in SOFA score independently increases the probability of adverse outcome in patients hospitalized with acute pancreatitis. SOFA score > 5 is highly predictive of in-hospital mortality (O.R. 32.00; C.I. 6.73-152.5; p = 0.001) compared to other scores. The use of an easy tool, validated in intensive care setting such as SOFA score, might help to better stratify the risk of in-hospital mortality and/or clinical worsening in patients hospitalized with acute pancreatitis in internal medicine ward.
Ombretta Para; Lorenzo Caruso; Maria Teresa Savo; Elisa Antonielli; Eleonora Blasi; Fabio Capello; Tiziana Ciarambino; Lorenzo Corbo; Armando Curto; Margherita Giampieri; Lucia Maddaluni; Giacomo Zaccagnini; Carlo Nozzoli. The challenge of prognostic markers in acute pancreatitis: internist’s point of view. Journal of Genetic Engineering and Biotechnology 2021, 19, 1 -9.
AMA StyleOmbretta Para, Lorenzo Caruso, Maria Teresa Savo, Elisa Antonielli, Eleonora Blasi, Fabio Capello, Tiziana Ciarambino, Lorenzo Corbo, Armando Curto, Margherita Giampieri, Lucia Maddaluni, Giacomo Zaccagnini, Carlo Nozzoli. The challenge of prognostic markers in acute pancreatitis: internist’s point of view. Journal of Genetic Engineering and Biotechnology. 2021; 19 (1):1-9.
Chicago/Turabian StyleOmbretta Para; Lorenzo Caruso; Maria Teresa Savo; Elisa Antonielli; Eleonora Blasi; Fabio Capello; Tiziana Ciarambino; Lorenzo Corbo; Armando Curto; Margherita Giampieri; Lucia Maddaluni; Giacomo Zaccagnini; Carlo Nozzoli. 2021. "The challenge of prognostic markers in acute pancreatitis: internist’s point of view." Journal of Genetic Engineering and Biotechnology 19, no. 1: 1-9.
Vaccination is one of the greatest achievements of public health. Vaccination programs have contributed to the decline in mortality and morbidity of various infectious diseases. This review aims to investigate the impact of sex/gender on the vaccine acceptance, responses, and outcomes. The studies were identified by using PubMed, until 30th June 2020. The search was performed by using the following keywords: SARS-CoV-2, COVID-19, gender, sex, vaccine, adverse reaction. Clinical trials, retrospective and prospective studies were included. Studies written in languages other than English were excluded. Studies were included if gender differences in response to vaccination trials were reported. All selected studies were qualitatively analyzed. Innate recognition and response to viruses, as well as, adaptive immune responses during viral infections, differ between females and males. Unfortunately, a majority of vaccine trials have focused on healthy people, with ages between 18 to 65 years, excluding the elderly, pregnant women, post-menopausal female and children. In conclusion, it is apparent that the design of vaccines and vaccine strategies should be sex-specific, to reduce adverse reactions in females and increase immunogenicity in males. It should be mandatory to examine sex-related variables in pre-clinical and clinical vaccine trials, such as their crucial role for successful prevention of pandemic COVID-19.
Tiziana Ciarambino; Elena Barbagelata; Graziamaria Corbi; Immacolata Ambrosino; Cecilia Politi; Franco Lavalle; Anna Ruggieri; Annamaria Moretti. Gender differences in vaccine therapy: where are we in COVID-19 pandemic? Monaldi Archives for Chest Disease 2021, 1 .
AMA StyleTiziana Ciarambino, Elena Barbagelata, Graziamaria Corbi, Immacolata Ambrosino, Cecilia Politi, Franco Lavalle, Anna Ruggieri, Annamaria Moretti. Gender differences in vaccine therapy: where are we in COVID-19 pandemic? Monaldi Archives for Chest Disease. 2021; ():1.
Chicago/Turabian StyleTiziana Ciarambino; Elena Barbagelata; Graziamaria Corbi; Immacolata Ambrosino; Cecilia Politi; Franco Lavalle; Anna Ruggieri; Annamaria Moretti. 2021. "Gender differences in vaccine therapy: where are we in COVID-19 pandemic?" Monaldi Archives for Chest Disease , no. : 1.
Background: The global active prevalence of migraines is approximately 14.7%. Oxygen therapy may reduce the use of non-steroidal anti-inflammatory drugs (NSAIDs) which often have various negative side effects. The purpose of this systematic review is to analyze the literature on the efficacy of high flow oxygen for the management of headache disorders, compared to placebo treatment. Methods: Studies were identified by PubMed, Web of Science and Scopus database from 1980 to the 30 October 2020. The search included the following terms: “oxygen therapy” and “headache” and “migraine”. Studies were included if high flow oxygen was used in the treatment of headache disorders. All selected studies were qualitatively analyzed. Results: Our literature search identified 71 studies, of which 65 were discarded and 6 were included in the meta-analysis. The random effect model did not show a pooled significant resolution of headache disorders (OR 2.08 (95% CI 0.92–4.70), p < 0.0001) in the oxygen therapy group compared to the placebo group. Conclusion: In our systematic review of six studies, there were no significant differences between high flow oxygen and placebo treatment groups.
Tiziana Ciarambino; Gennaro Sansone; Giovanni Menna; Ombretta Para; Giuseppe Signoriello; Laura Leoncini; Mauro Giordano. Oxygen Therapy in Headache Disorders: A Systematic Review. Brain Sciences 2021, 11, 379 .
AMA StyleTiziana Ciarambino, Gennaro Sansone, Giovanni Menna, Ombretta Para, Giuseppe Signoriello, Laura Leoncini, Mauro Giordano. Oxygen Therapy in Headache Disorders: A Systematic Review. Brain Sciences. 2021; 11 (3):379.
Chicago/Turabian StyleTiziana Ciarambino; Gennaro Sansone; Giovanni Menna; Ombretta Para; Giuseppe Signoriello; Laura Leoncini; Mauro Giordano. 2021. "Oxygen Therapy in Headache Disorders: A Systematic Review." Brain Sciences 11, no. 3: 379.
In COVID-19 disease, are reported gender differences in relation to severity and death. The aim of this review is to highlight gender differences in the immune response to COVID-19. The included studies were identified using PubMed, until 30 October 2020. The search included the following keywords: SARS-CoV-2, COVID-19, gender, age, sex, and immune system. Literature described that females compared to males have greater inflammatory, antiviral, and humoral immune responses. In female, estrogen is a potential ally to alleviate SARS-COV-2 disease. In male, testosterone reduces vaccination response and depresses the cytokine response. In the older patients, and in particular, in female older patients, it has been reported a progressive functional decline in the immune systems. Differences by gender were reported in infection diseases, including SARS-CoV-2. These data should be confirmed by the other epidemiological studies.
Tiziana Ciarambino; Ombretta Para; Mauro Giordano. Immune system and COVID-19 by sex differences and age. Women's Health 2021, 17, 1 .
AMA StyleTiziana Ciarambino, Ombretta Para, Mauro Giordano. Immune system and COVID-19 by sex differences and age. Women's Health. 2021; 17 ():1.
Chicago/Turabian StyleTiziana Ciarambino; Ombretta Para; Mauro Giordano. 2021. "Immune system and COVID-19 by sex differences and age." Women's Health 17, no. : 1.
Parkinson’s disease has been found to significantly affect health-related quality of life. The gender differences of the health-related quality of life of subjects with Parkinson’s disease have been observed in a number of studies. These differences have been reported in terms of the age at onset, clinical manifestations, and response to therapy. In general, women with Parkinson’s disease showed more positive disease outcomes with regard to emotion processing, non-motor symptoms, and cognitive functions, although women report more Parkinson’s disease-related clinical manifestations. Female gender predicted poor physical functioning and socioemotional health-related quality of life, while male gender predicted the cognitive domain of health-related quality of life. Some studies reported gender differences in the association between health-related quality of life and non-motor symptoms. Depression and fatigue were the main causes of poorer health-related quality of life in women, even in the early stages of Parkinson’s disease. The aim of this review was to collect the best available evidence on gender differences in the development of Parkinson’s disease symptoms and health-related quality of life.
Pietro Crispino; Miriam Gino; Elena Barbagelata; Tiziana Ciarambino; Cecilia Politi; Immacolata Ambrosino; Rosalia Ragusa; Marina Marranzano; Antonio Biondi; Marco Vacante. Gender Differences and Quality of Life in Parkinson’s Disease. International Journal of Environmental Research and Public Health 2020, 18, 198 .
AMA StylePietro Crispino, Miriam Gino, Elena Barbagelata, Tiziana Ciarambino, Cecilia Politi, Immacolata Ambrosino, Rosalia Ragusa, Marina Marranzano, Antonio Biondi, Marco Vacante. Gender Differences and Quality of Life in Parkinson’s Disease. International Journal of Environmental Research and Public Health. 2020; 18 (1):198.
Chicago/Turabian StylePietro Crispino; Miriam Gino; Elena Barbagelata; Tiziana Ciarambino; Cecilia Politi; Immacolata Ambrosino; Rosalia Ragusa; Marina Marranzano; Antonio Biondi; Marco Vacante. 2020. "Gender Differences and Quality of Life in Parkinson’s Disease." International Journal of Environmental Research and Public Health 18, no. 1: 198.
As the main title ‘COVID-19 revolution: a new challenge for the internist’ states, the global coronavirus infection disease 2019 (COVID-19) pandemic represented a new challenge for the internists. This paper is part of a series of articles written during the difficult period of the ongoing global pandemic and published all together in this fourth issue of the Italian Journal of Medicine, with the aim of sharing the direct experiences of those who were the first to face this severe emergency, expressing each point of view in the management of COVID-19 in relation to other diseases. Each article is therefore the result of many efforts and a joint collaboration between many colleagues from the Departments of Internal Medicine or Emergency Medicine of several Italian hospitals, engaged in the front line during the pandemic. These preliminary studies therefore cover diagnostic tools available to health care personnel, epidemiological reflections, possible new therapeutic approaches, discharge and reintegration procedures to daily life, the involvement of the disease not only in the lung, aspects related to various comorbidities, such as: coagulopathies, vasculitis, vitamin D deficiency, gender differences, etc.. The goal is to offer a perspective, as broad as possible, of everything that has been done to initially face the pandemic in its first phase and provide the tools for an increasingly better approach, in the hope of not arriving unprepared to a possible second wave. This paper in particular deals with COVID-19 and gender differences.
Tiziana Ciarambino; Sara Rotunno; Emanuele Bizzi; Federica Lorenzi. COVID-19 and gender differences: lights and shadows. Italian Journal of Medicine 2020, 14, 228 -230.
AMA StyleTiziana Ciarambino, Sara Rotunno, Emanuele Bizzi, Federica Lorenzi. COVID-19 and gender differences: lights and shadows. Italian Journal of Medicine. 2020; 14 (4):228-230.
Chicago/Turabian StyleTiziana Ciarambino; Sara Rotunno; Emanuele Bizzi; Federica Lorenzi. 2020. "COVID-19 and gender differences: lights and shadows." Italian Journal of Medicine 14, no. 4: 228-230.
Tiziana Ciarambino; Orazio V Giannico; Giovanni Menna; Gennaro Sansone; Ombretta Para; Mauro Giordano; Antonio Corrente; Luigi E Adinolfi. Diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB): a sistematic review. 2020, 1 .
AMA StyleTiziana Ciarambino, Orazio V Giannico, Giovanni Menna, Gennaro Sansone, Ombretta Para, Mauro Giordano, Antonio Corrente, Luigi E Adinolfi. Diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB): a sistematic review. . 2020; ():1.
Chicago/Turabian StyleTiziana Ciarambino; Orazio V Giannico; Giovanni Menna; Gennaro Sansone; Ombretta Para; Mauro Giordano; Antonio Corrente; Luigi E Adinolfi. 2020. "Diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB): a sistematic review." , no. : 1.
(1) Background: Circulating micro-RNAs (miRNAs) modulate the expression of molecules in diabetes. We evaluated the expression of serum miRNA-195-5p and -451a in diabetic patients with ischemic stroke and correlated them with two markers of brain tissue integrity. (2) Methods: Seventy-eight subjects with acute ischemic stroke (AIS) or transient ischemic attack (TIA) (40 with diabetes) were enrolled. Serum miRNA levels, brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor A (VEGF-A) were assessed at admission and 24 and 72 h after a post-ischemic stroke, and were compared to 20 controls. (3) Results: Both circulating miRNAs were two-fold up-regulated in diabetic AIS and TIA patients compared to non-diabetics. Their levels progressively decreased at 24 and 72 h in both AIS and TIA patients. Interestingly, in the non-diabetic TIA group, both circulating miRNAs, although higher than the controls, tended to achieve a complete decay after 72 h. Furthermore, miRNA-195-5p and miRNA-451a levels inversely correlated with both BDNF and VEGF-A serum levels. (4) Conclusions: These data show a different profile of both micro-RNAs in diabetic versus non-diabetic patients after acute ischemic stroke, suggesting their pivotal role in cerebrovascular ischemic attack.
Mauro Giordano; Maria Trotta; Tiziana Ciarambino; Michele D’Amico; Marilena Galdiero; Federico Schettini; Diego Paternosto; Marta Salzillo; Roberto Alfano; Vincenzo Andreone; Lorenzo Malatino; Gianni Biolo; Giuseppe Paolisso; Luigi Adinolfi. Circulating MiRNA-195-5p and -451a in Diabetic Patients with Transient and Acute Ischemic Stroke in the Emergency Department. International Journal of Molecular Sciences 2020, 21, 7615 .
AMA StyleMauro Giordano, Maria Trotta, Tiziana Ciarambino, Michele D’Amico, Marilena Galdiero, Federico Schettini, Diego Paternosto, Marta Salzillo, Roberto Alfano, Vincenzo Andreone, Lorenzo Malatino, Gianni Biolo, Giuseppe Paolisso, Luigi Adinolfi. Circulating MiRNA-195-5p and -451a in Diabetic Patients with Transient and Acute Ischemic Stroke in the Emergency Department. International Journal of Molecular Sciences. 2020; 21 (20):7615.
Chicago/Turabian StyleMauro Giordano; Maria Trotta; Tiziana Ciarambino; Michele D’Amico; Marilena Galdiero; Federico Schettini; Diego Paternosto; Marta Salzillo; Roberto Alfano; Vincenzo Andreone; Lorenzo Malatino; Gianni Biolo; Giuseppe Paolisso; Luigi Adinolfi. 2020. "Circulating MiRNA-195-5p and -451a in Diabetic Patients with Transient and Acute Ischemic Stroke in the Emergency Department." International Journal of Molecular Sciences 21, no. 20: 7615.
Sarcoidosis is a granulomatous disorder of unknown etiology characterized by noncaseating granulomas virtually in every organ and tissue. This finding represents the most important diagnostic clue to reach a correct definition of sarcoidosis, although the biopsy is invasive and has several risk procedures. Several efforts are made to suspect the diagnosis of sarcoidosis by combining noninvasive elements, in particular from imaging, though these findings are often nonspecific and reflect the wide multifactorial pathogenesis. Every effort should be made to obtain a detailed radiological picture that, if associated with a suggestive clinical picture, could avoid the need of biopsy in some specific cases. In this narrative review, we aim to describe main computed tomography (CT) features of pulmonary and abdominal sarcoidosis, by reporting strengths and limits of this technique, in particular for the identification of extrapulmonary, isolated disease.
Claudio Tana; Iginio Donatiello; Maria Gabriella Coppola; Fabrizio Ricci; Marica Tina Maccarone; Tiziana Ciarambino; Francesco Cipollone; Maria Adele Giamberardino. CT Findings in Pulmonary and Abdominal Sarcoidosis. Implications for Diagnosis and Classification. Journal of Clinical Medicine 2020, 9, 3028 .
AMA StyleClaudio Tana, Iginio Donatiello, Maria Gabriella Coppola, Fabrizio Ricci, Marica Tina Maccarone, Tiziana Ciarambino, Francesco Cipollone, Maria Adele Giamberardino. CT Findings in Pulmonary and Abdominal Sarcoidosis. Implications for Diagnosis and Classification. Journal of Clinical Medicine. 2020; 9 (9):3028.
Chicago/Turabian StyleClaudio Tana; Iginio Donatiello; Maria Gabriella Coppola; Fabrizio Ricci; Marica Tina Maccarone; Tiziana Ciarambino; Francesco Cipollone; Maria Adele Giamberardino. 2020. "CT Findings in Pulmonary and Abdominal Sarcoidosis. Implications for Diagnosis and Classification." Journal of Clinical Medicine 9, no. 9: 3028.
Coronavirus Disease-2019 (COVID-19) is the worst worldwide pandemic with more than 12,000,000 cases and 560,000 deaths until 14th July 2020. Men were more infected by COVID-19 than women, and male subjects with underlying conditions, including diabetes, hypertension, and cardiovascular diseases developed a severe form of the affection, with increased mortality rate. Many factors can contribute to the disparity in disease outcomes, such as hormone-specific reaction and activity of X-linked genes, which modulate the innate and adaptive immune response to virus infection. Until now, only the Remdesivir was approved by FDA (Food Drug Administration) for COVID-19 treatment, although several clinical trials are ongoing worldwide also on other drugs. In this review, we analyzed published studies on several drugs (chloroquine or hydroxychloroquine, remdesivir, favipiravir, lopinavir-ritonavir in combination, tocilizumab, plasma, and immunoglobulins) with some efficacy to COVID-19 in humans, and evaluated if there were a gender analysis of the available data. In our opinion, it is essential to report data about COVID-19 disaggregated by sex, age, and race, because the knowledge of gender differences is fundamental to identify effective and customized treatments to reduce hospitalizations, admissions to intensive care units, and mortality.
Immacolata Ambrosino; Elena Barbagelata; Graziamaria Corbi; Tiziana Ciarambino; Cecilia Politi; Anna Maria Moretti. Gender differences in treatment of Coronavirus Disease-2019. Monaldi Archives for Chest Disease 2020, 90, 1 .
AMA StyleImmacolata Ambrosino, Elena Barbagelata, Graziamaria Corbi, Tiziana Ciarambino, Cecilia Politi, Anna Maria Moretti. Gender differences in treatment of Coronavirus Disease-2019. Monaldi Archives for Chest Disease. 2020; 90 (4):1.
Chicago/Turabian StyleImmacolata Ambrosino; Elena Barbagelata; Graziamaria Corbi; Tiziana Ciarambino; Cecilia Politi; Anna Maria Moretti. 2020. "Gender differences in treatment of Coronavirus Disease-2019." Monaldi Archives for Chest Disease 90, no. 4: 1.
The aim of this systematic review was to assess AKI (acute kidney injury) in adult patients, treated with vancomycin (V) + piperacillin/tazobactam (PT) compared to V monotherapy. Studies were found in Pubmed, Web of Science and Scopus databases. Articles not in English, pediatric studies and case reports were excluded. A study is eligible for inclusion if the adjusted Odds ratio (aOR) for AKI in V + PT compared to V monotherapy groups, could be extracted or determined from available data. Six retrospective cohort studies were eligible for inclusion criteria and so they were included in the analysis. All studies separately showed a significant higher risk of developing AKI (OR > 1, p < 0.05) in V + PT group compared to V monotherapy group. Considering the methodological difference of included studies, a random effect model was preferred. The model showed a pooled significant higher risk of developing AKI [OR 2.77 (95% CI 1.94, 3.96), p < 0.0001] in V + PT group compared to V group. Association of V and PT appears to be associated with a greater risk of AKI compared to V in monotherapy. These results may serve as the impetus for further evaluation into true mechanisms behind this additive nephrotoxic effect and its potential implications on mortality.
Tiziana Ciarambino; Orazio Valerio Giannico; Amalia Campanile; Paolo Tirelli; Ombretta Para; Giuseppe Signoriello; Mauro Giordano. Acute kidney injury and vancomycin/piperacillin/tazobactam in adult patients: a systematic review. Internal and Emergency Medicine 2020, 15, 327 -331.
AMA StyleTiziana Ciarambino, Orazio Valerio Giannico, Amalia Campanile, Paolo Tirelli, Ombretta Para, Giuseppe Signoriello, Mauro Giordano. Acute kidney injury and vancomycin/piperacillin/tazobactam in adult patients: a systematic review. Internal and Emergency Medicine. 2020; 15 (2):327-331.
Chicago/Turabian StyleTiziana Ciarambino; Orazio Valerio Giannico; Amalia Campanile; Paolo Tirelli; Ombretta Para; Giuseppe Signoriello; Mauro Giordano. 2020. "Acute kidney injury and vancomycin/piperacillin/tazobactam in adult patients: a systematic review." Internal and Emergency Medicine 15, no. 2: 327-331.
Emilio Laviscio; Tiziana Ciarambino; Annita Imbriani; Mauro Giordano; Filippo Topo. A successful case report in woman: A gender medicine? Archives of Surgery and Clinical Research 2019, 3, 032 -033.
AMA StyleEmilio Laviscio, Tiziana Ciarambino, Annita Imbriani, Mauro Giordano, Filippo Topo. A successful case report in woman: A gender medicine? Archives of Surgery and Clinical Research. 2019; 3 (1):032-033.
Chicago/Turabian StyleEmilio Laviscio; Tiziana Ciarambino; Annita Imbriani; Mauro Giordano; Filippo Topo. 2019. "A successful case report in woman: A gender medicine?" Archives of Surgery and Clinical Research 3, no. 1: 032-033.
We have evaluated circulating miRNAs (-195-5p and -451a) in subjects with acute ischemic stroke (AIS) and in patients with transient ischemic attack (TIA). In this study, 18 subjects with AIS and 18 patients with TIA were enrolled and examined at admission (T0) and at 24 h and 48 h after admission, and compared to 20 controls (C). At T0, circulating miRNA-195-5p and -451a were significantly upregulated in both AIS and TIA patients, compared to C. We also observed a progressive reduction of circulating miRNA levels at 24 h and 48 h in both AIS and TIA patients. Hypoxia inducible factor 1alpha (HIF-1α) serum level was significantly increased at T0, in both AIS and TIA patients, in comparison to C (both p < 0.01 vs. C) and it decreased in both AIS and TIA patients at 24 h and at 48 h, in comparison to T0 (both p < 0.01 vs. T0). Vascular endothelial growth factor (VEGF) serum level was significantly decreased at T0, in both AIS and TIA patients, if compared to C (both p < 0.01 vs. C) and increased, in both AIS and TIA patients, at 24 h and 48 h, if compared to T0 (both p < 0.01 vs. T0). The elevated expression of miRNA-195-5p and miRNA-451a significantly decreased over time at 24 h and 48 h, and it is associated with decreased HIF-α levels and increased VEGF serum levels. These data may suggest a role for this miRNAs as biomarker in the pathogenesis and prognosis of AIS patients and for the first time also in TIA patients.
Mauro Giordano; Tiziana Ciarambino; Michele D’Amico; Maria Consiglia Trotta; Alessandra Marinella Di Sette; Raffaele Marfella; Lorenzo Malatino; Giuseppe Paolisso; Luigi Elio Adinolfi. Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department. Journal of Clinical Medicine 2019, 8, 130 .
AMA StyleMauro Giordano, Tiziana Ciarambino, Michele D’Amico, Maria Consiglia Trotta, Alessandra Marinella Di Sette, Raffaele Marfella, Lorenzo Malatino, Giuseppe Paolisso, Luigi Elio Adinolfi. Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department. Journal of Clinical Medicine. 2019; 8 (2):130.
Chicago/Turabian StyleMauro Giordano; Tiziana Ciarambino; Michele D’Amico; Maria Consiglia Trotta; Alessandra Marinella Di Sette; Raffaele Marfella; Lorenzo Malatino; Giuseppe Paolisso; Luigi Elio Adinolfi. 2019. "Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department." Journal of Clinical Medicine 8, no. 2: 130.
We have evaluated gender-related differences in cardiovascular disease. In particular, in coronary heart disease, atrial fibrillation, arterial hypertension, venous thromboembolism and diabetes mellitus.
Tiziana Ciarambino; Miriam Gino; Paola Gnerre; Elena Barbagelata; Nunzia Barone; Francesca Saladini; Federica Lorenzi; Marta Zanon; Maria Cristina Pasquini; Cecilia Politi. Young FADOI and gender medicine: sex gender differences in cardiovascular disease. Italian Journal of Medicine 2018, 12, 23 -31.
AMA StyleTiziana Ciarambino, Miriam Gino, Paola Gnerre, Elena Barbagelata, Nunzia Barone, Francesca Saladini, Federica Lorenzi, Marta Zanon, Maria Cristina Pasquini, Cecilia Politi. Young FADOI and gender medicine: sex gender differences in cardiovascular disease. Italian Journal of Medicine. 2018; 12 (1):23-31.
Chicago/Turabian StyleTiziana Ciarambino; Miriam Gino; Paola Gnerre; Elena Barbagelata; Nunzia Barone; Francesca Saladini; Federica Lorenzi; Marta Zanon; Maria Cristina Pasquini; Cecilia Politi. 2018. "Young FADOI and gender medicine: sex gender differences in cardiovascular disease." Italian Journal of Medicine 12, no. 1: 23-31.
Atrial fibrillation (AF) is the most common cardiac arrhythmia. This analysis aimed to determine the sex-gender differences in patients with AF enrolled in the observational ATAAF study. The study was conducted in 360 centers in Italy. During a 4-week period, all consecutive inpatients and outpatients aged ≥18 years, with a documented primary or secondary diagnosis of AF, were included. A total of 7148 patients (47% females) were enrolled. Females were significantly older, they more frequently needed assistance and were affected with severe cognitive impairment. The preferred anti-arrhythmic strategy in both genders was heart rate control (females: 54.7%, males: 48.4%, p75 was not (1.00, 95% CI 0.79-1.26). This study defines sex-gender differences in AF patients, including lower OAC prescription in females despite of higher thrombotic risk. Concomitant higher hemorrhagic risk and other characteristics that were more frequent in females (i.e. severe cognitive and functional impairment) may at least partly explain this trend towards gender-related under-prescription of OAC.
Cecilia Politi; Tiziana Ciarambino; Letizia Riva; Stefania Frasson; Donata Lucci; Gualberto Gussoni; Lucio Gonzini; Mauro Campanini; Michele Gulizia; Giuseppe Di Pasquale; Giovanni Mathieu; on behalf of ATA-AF Steering Committee and Investigators. Sex-gender and atrial fibrillation treatment in the ATA-AF Study. Italian Journal of Medicine 2016, 10, 207 -212.
AMA StyleCecilia Politi, Tiziana Ciarambino, Letizia Riva, Stefania Frasson, Donata Lucci, Gualberto Gussoni, Lucio Gonzini, Mauro Campanini, Michele Gulizia, Giuseppe Di Pasquale, Giovanni Mathieu, on behalf of ATA-AF Steering Committee and Investigators. Sex-gender and atrial fibrillation treatment in the ATA-AF Study. Italian Journal of Medicine. 2016; 10 (3):207-212.
Chicago/Turabian StyleCecilia Politi; Tiziana Ciarambino; Letizia Riva; Stefania Frasson; Donata Lucci; Gualberto Gussoni; Lucio Gonzini; Mauro Campanini; Michele Gulizia; Giuseppe Di Pasquale; Giovanni Mathieu; on behalf of ATA-AF Steering Committee and Investigators. 2016. "Sex-gender and atrial fibrillation treatment in the ATA-AF Study." Italian Journal of Medicine 10, no. 3: 207-212.
Women get sick more, use more health services, take more drugs, and have a higher frequency of serious adverse reactions. Despite this, the drugs we use are little studied in women: both clinical studies and pre-clinical experiments are carried out predominantly in males and the young. Before 1990, no more than 26-30% of women were usually enrolled in a trial, so we lacked the statistical power of showing the efficacy and safety of the drugs being studied in the whole population. The gender blindness (transposition of the male studies in female populations) resulted in a lack of awareness of the differences between males and females, and this prevented both genders from receiving the best possible care. This gender bias also, to a lower degree, hurts men: depression, migraines, osteoporosis have not been studied properly in males. Although the process is slow, the scientific community has begun to pay more attention to direct and indirect influences that gender exercise on biological mechanisms, and this includes both internal and external cultural and environmental factors. Therefore, the differences between the old, the young, children, and pregnant women (considered the third gender group) will become increasingly more important as care becomes more personalized. The first course of gender medicine was established only in 2002 at Columbia University, New York, USA. The World Health Organization has incorporated gender medicine into the Equity Act. This implies that the treatment given must be the most appropriate and best suited the individual patient’s gender. The Committee on Women’s Health of the Ministry of Health in Italy was established in 2007. Institutions now pay great attention to the importance of this clinical perspective and are sensitive to the need for change. This review focuses on specific open questions regarding gender: pharmacology, clinical trial recruitment, cardiovascular prevention, stroke, osteoporosis, chronic obstructive pulmonary disease, depression, and discusses presentations made to the 1st course of gender medicine organized as part of the 18th National Congress of the Federation of Associations of Hospital Doctors on Internal Medicine (FADOI), 2012.
Cecilia Politi; Tiziana Ciarambino; Flavia Franconi; Lucrezia De Feudis; Maria Carolina Mayer; Alessandra Martignoni; Ilaria Giovi; Michela Tonani; Salvatore La Carrubba; Anna Maria Moretti; Carmen Martino; Giovanni Scanelli. Gender medicine: an up-date. Italian Journal of Medicine 2013, 7, 1 .
AMA StyleCecilia Politi, Tiziana Ciarambino, Flavia Franconi, Lucrezia De Feudis, Maria Carolina Mayer, Alessandra Martignoni, Ilaria Giovi, Michela Tonani, Salvatore La Carrubba, Anna Maria Moretti, Carmen Martino, Giovanni Scanelli. Gender medicine: an up-date. Italian Journal of Medicine. 2013; 7 (2):1.
Chicago/Turabian StyleCecilia Politi; Tiziana Ciarambino; Flavia Franconi; Lucrezia De Feudis; Maria Carolina Mayer; Alessandra Martignoni; Ilaria Giovi; Michela Tonani; Salvatore La Carrubba; Anna Maria Moretti; Carmen Martino; Giovanni Scanelli. 2013. "Gender medicine: an up-date." Italian Journal of Medicine 7, no. 2: 1.