Adrian Rothenfluh

Dr. Adrian Rothenfluh

orcid

Research Focus & Metrics

Academic Career Length

32Years (1995-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 1998 in Cell
Verified
Journal Article
Closed access
JPJeffrey L Price
Jeffrey L Price
JBJustin Blau
Justin Blau
ARAdrian Rothenfluh
Adrian Rothenfluh
MAMarla Abodeely
Marla Abodeely
BKBrian Kloss
Brian Kloss
MYMichael W Young
Michael W Young

9 August 2006 in Psychopharmacology
Verified
Journal Article
Closed access
PDF file
SMShannon G. Matta
Shannon G. Matta
DBDavid J. Balfour
David J. Balfour
NBNeal L. Benowitz
Neal L. Benowitz
RBR. Thomas Boyd
R. Thomas Boyd
JBJerry J. Buccafusco
Jerry J. Buccafusco
JZJeffrey M. Zirger
Jeffrey M. Zirger

1 July 1998 in Cell
Verified
Journal Article
Closed access
BKBrian Kloss
Brian Kloss
JPJeffrey L Price
Jeffrey L Price
LSLino Saez
Lino Saez
JBJustin Blau
Justin Blau
ARAdrian Rothenfluh
Adrian Rothenfluh
MYMichael W Young
Michael W Young

22 March 1996 in Science
Verified
Journal Article
Closed access
PDF file
MMMichael P. Myers
Michael P. Myers
KWKaren Wager-Smith
Karen Wager-Smith
ARAdrian Rothenfluh
Adrian Rothenfluh
MYMichael W. Young
Michael W. Young
Two genes, period ( per ) and timeless ( tim ), are required for production of circadian rhythms in Drosophila . The proteins encoded by these genes (PER and TIM) physically interact, and the timing of their association and nuclear localization is believed to promote cycles of per and tim transcription through an autoregulatory feedback loop. Here it is shown that TIM protein may also couple this molecular pacemaker to the environment, because TIM is rapidly degraded after exposure to light. TIM accumulated rhythmically in nuclei of eyes and in pacemaker cells of the brain. The phase of these rhythms was differentially advanced or delayed by light pulses delivered at different times of day, corresponding with phase shifts induced in the behavioral rhythms.

3 November 1995 in Science
Verified
Journal Article
Closed access
PDF file
ASAmita Sehgal
Amita Sehgal
ARAdrian Rothenfluh
Adrian Rothenfluh
MHMelissa Hunter-Ensor
Melissa Hunter-Ensor
YCYifeng Chen
Yifeng Chen
MMMichael P. Myers
Michael P. Myers
MYMichael W. Young
Michael W. Young
The clock gene timeless ( tim ) is required for circadian rhythmicity in Drosophila . The accumulation of tim RNA followed a circadian rhythm, and the phase and period of the tim RNA rhythm were indistinguishable from those that have been reported for per . The tim RNA oscillations were found to be dependent on the presence of PER and TIM proteins, which demonstrates feedback control of tim by a mechanism previously shown to regulate per expression. The cyclic expression of tim appears to dictate the timing of PER protein accumulation and nuclear localization, suggesting that tim promotes circadian rhythms of per and tim transcription by restricting per RNA and PER protein accumulation to separate times of day.

1 October 2011 in Current Biology
Verified
Journal Article
Closed access
CCChih-Chiang Chan
Chih-Chiang Chan
SSShane Scoggin
Shane Scoggin
DWDong Wang
Dong Wang
SCSmita Cherry
Smita Cherry
TDTodd Dembo
Todd Dembo
PHP. Robin Hiesinger
P. Robin Hiesinger