Liquid-phase exfoliation (LPE) is a widely used and promising method for the production of 2D nanomaterials because it can be scaled up relatively easily. Nevertheless, the yields achieved by this process are still low, ranging between 2% and 5%, which makes the large-scale production of these materials difficult. In this report, we investigate the cause of these low yields by examining the sonication-assisted LPE of graphene, boron nitride nanosheets (BNNSs), and molybdenum disulfide nanosheets (MoS₂ NS). Our results show that the low yields are caused by an equilibrium that is formed between the exfoliated nanosheets and the flocculated ones during the sonication process. This study provides an understanding of this behaviour, which prevents further exfoliation of nanosheets. By avoiding this equilibrium, we were able to increase the total yields of graphene, BNNSs, and MoS₂ NS up to 14%, 44%, and 29%, respectively. Here, we demonstrate a modified LPE process that leads to the high-yield production of 2D nanomaterials.

The presented study focuses on the modification of polypropylene (PP) film with tetraethyl orthosilicate (TEOS) under heterogeneous conditions via polydopamine/polyethylene imine (PDA/PEI) chemistry using a facile dip-coating procedure to attain hydrophilic mineral-rich surfaces. Thus, the resulting PP-based films were further immersed in ion-rich simulated body fluid (SBF) to deposit Ca-based minerals onto the film’s surfaces efficiently. In addition, the chemical reaction mechanism on PP film was proposed, and mineralisation potential inspected by determination of functional groups of deposits, zeta potential, hydrophilicity and surface morphology/topography using Fourier transform infrared (FTIR) spectroscopy, streaming potential, water contact angle (WCA), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The obtained results show the improved wettability of samples on account of PDA inclusion (WCA was reduced from 103° for pure PP film to 28° for PDA-modified film), as well as the presence of functional groups, due to the PDA/PEI/TEOS surface functionalisation, increased the ability of minerals to nucleate on the PP film’s surface when it was exposed to an SBF medium. Moreover, the higher surface roughness due to the silica coatings influenced the enhanced anchoring and attachment of calcium phosphate (CaP), revealing the potential of such a facile approach to modify the chemically inert PP films, being of particular interest in different fields, including regenerative medicine.

The influence of two tuning agents, polyglycerol ester (PE) and triblock copolymer (TC), on the properties of glycerol monooleate (MO) liquid crystalline phase (LCP) was investigated to achieve the therapeutic concentration of vancomycin hydrochloride (VHCl) into the eye, topically during 60 min (1 h) and intravitreally during 2880 min (48 h). Different techniques were used to elucidate the impact of surfactants on the structure of the LCP: polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), and in vitro release tests I and II (simulating local and intravitreal application in the eye). The structure analysis by SAXS depicts that the inclusion of PE into the MO LCP provided partial transition of a hexagonal phase into a lamellar phase, and TC induced a partial transition of a hexagonal phase into an LCP which identification was difficult. The LCP modulated with PE and TC demonstrated different VHCl’s release patterns and were evaluated by comparing our release data with the literature data. The comparison indicated that the LCP modulated with 30% w/w PE could be a promising VHCl delivery system intravitreally during 2880 min.