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Prof. Masayuki Shima
Department of Public Health, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo 663-8501, Japan

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0 Air Pollution
0 Allergy
0 Asthma
0 Child Health
0 Epidemiology

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Journal article
Published: 13 June 2021 in Viruses
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Interferon gamma (IFN-γ) is considered a key moderator of cell-mediated immunity. However, little is known about its association with granzyme B, which plays an important role in the effector function of cytotoxic T lymphocytes (CTLs). In the present study, we collected blood samples from 32 healthy adults before and after vaccination with inactivated influenza vaccine in 2017/18 to measure the levels of IFN-γ and granzyme B, which play roles in cell-mediated immunity, and hemagglutination inhibition (HAI) antibody, which plays a role in humoral immunity. The levels of IFN-γ and granzyme B were significantly correlated both before and after vaccination. Furthermore, the post-vaccine fold increases in the IFN-γ and granzyme B levels were significantly correlated. The levels of IFN-γ and granzyme B decreased five months after vaccination in more than half of the subjects who exhibited an increase in IFN-γ and granzyme B at two weeks post-vaccination. This is the first study to investigate the correlation between IFN-γ and granzyme B levels following influenza vaccination. Our study suggests that both IFN-γ and granzyme B can be used as markers of cell-mediated immunity.

ACS Style

Naruhito Otani; Kazuhiko Nakajima; Kaori Ishikawa; Kaoru Ichiki; Takashi Ueda; Yoshio Takesue; Takuma Yamamoto; Susumu Tanimura; Masayuki Shima; Toshiomi Okuno. Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination. Viruses 2021, 13, 1137 .

AMA Style

Naruhito Otani, Kazuhiko Nakajima, Kaori Ishikawa, Kaoru Ichiki, Takashi Ueda, Yoshio Takesue, Takuma Yamamoto, Susumu Tanimura, Masayuki Shima, Toshiomi Okuno. Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination. Viruses. 2021; 13 (6):1137.

Chicago/Turabian Style

Naruhito Otani; Kazuhiko Nakajima; Kaori Ishikawa; Kaoru Ichiki; Takashi Ueda; Yoshio Takesue; Takuma Yamamoto; Susumu Tanimura; Masayuki Shima; Toshiomi Okuno. 2021. "Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination." Viruses 13, no. 6: 1137.

Journal article
Published: 31 May 2021 in Environmental Pollution
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Exposure to ambient air pollution is associated with maternal and child health. Some air pollutants exhibit similar behavior in the atmosphere, and some interact with each other; thus, comprehensive assessments of individual air pollutants are required. In this study, we developed national-scale monthly models for six air pollutants (NO, NO2, SO2, O3, PM2.5, and suspended particulate matter (SPM)) to obtain accurate estimates of pollutant concentrations at 1 km × 1 km resolution from 2010 through 2015 for application to the Japan Environment and Children's Study (JECS), which is a large-scale birth cohort study. We developed our models in the land use regression framework using random forests in conjunction with kriging. We evaluated the model performance via 5-fold location-based cross-validation. We successfully predicted monthly NO (r2 = 0.65), NO2 (r2 = 0.84), O3 (r2 = 0.86), PM2.5 (r2 = 0.79), and SPM (r2 = 0.64) concentrations. For SO2, a satisfactory model could not be developed (r2 = 0.45) because of the low SO2 concentrations in Japan. The performance of our models is comparable to those reported in previous studies at similar temporal and spatial scales. The model predictions in conjunction with the JECS will reveal the critical windows of prenatal and infancy exposure to ambient air pollutants, thus contributing to the development of environmental policies on air pollution.

ACS Style

Shin Araki; Hideki Hasunuma; Kouhei Yamamoto; Masayuki Shima; Takehiro Michikawa; Hiroshi Nitta; Shoji F. Nakayama; Shin Yamazaki. Estimating monthly concentrations of ambient key air pollutants in Japan during 2010–2015 for a national-scale birth cohort. Environmental Pollution 2021, 284, 117483 .

AMA Style

Shin Araki, Hideki Hasunuma, Kouhei Yamamoto, Masayuki Shima, Takehiro Michikawa, Hiroshi Nitta, Shoji F. Nakayama, Shin Yamazaki. Estimating monthly concentrations of ambient key air pollutants in Japan during 2010–2015 for a national-scale birth cohort. Environmental Pollution. 2021; 284 ():117483.

Chicago/Turabian Style

Shin Araki; Hideki Hasunuma; Kouhei Yamamoto; Masayuki Shima; Takehiro Michikawa; Hiroshi Nitta; Shoji F. Nakayama; Shin Yamazaki. 2021. "Estimating monthly concentrations of ambient key air pollutants in Japan during 2010–2015 for a national-scale birth cohort." Environmental Pollution 284, no. : 117483.

Journal article
Published: 30 May 2021 in Journal of Psychiatric Research
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Feelings about pregnancy and mother-infant bonding are associated with maternal mental health before and after childbirth. The current study examined factors associated with persistent distress at 12 months after childbirth among mothers with psychological distress in the first trimester, using data from the Japan Environment and Children's Study (JECS). Feelings about pregnancy were assessed using a questionnaire in the first trimester, and maternal mental health was assessed using the Kessler 6 (K6) in the first trimester and at 12 months after childbirth. In addition, mother-infant bonding was assessed using the Mother-to-Infant Bonding Scale Japanese version (MIBS-J) at 12 months after childbirth, and 5 items from the MIBS-J at one and six months after childbirth. Among the 97,415 mothers registered in the JECS, 24,324 mothers with psychological distress (K6 ≥ 5) in the first trimester were included in this analysis. The relationships between persistence of psychological distress at 12 months after childbirth with feelings about pregnancy and mother-infant bonding were analyzed. Both maternal negative feelings about pregnancy in the first trimester and mother-infant bonding after childbirth were significantly associated with persistent psychological distress at 12 months after childbirth (β = 0.02, p = 0.001 and β = 0.35, p < 0.001, respectively). The indirect effect of feelings about pregnancy on persistent distress through mother-infant bonding was also observed (β = 0.06, p < 0.001). These findings indicate that mother-infant bonding after childbirth may be important for improving the mental health of mothers with prenatal psychological distress.

ACS Style

Narumi Tokuda; Yoshiko Kobayashi; Hiroyuki Tanaka; Hideaki Sawai; Hiroaki Shibahara; Yasuhiro Takeshima; Masayuki Shima; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Takeo Nakayama; Hiroyasu Iso; Youichi Kurozawa; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh. Feelings about pregnancy and mother-infant bonding as predictors of persistent psychological distress in the perinatal period: The Japan Environment and Children's Study. Journal of Psychiatric Research 2021, 140, 132 -140.

AMA Style

Narumi Tokuda, Yoshiko Kobayashi, Hiroyuki Tanaka, Hideaki Sawai, Hiroaki Shibahara, Yasuhiro Takeshima, Masayuki Shima, Michihiro Kamijima, Shin Yamazaki, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Takeo Nakayama, Hiroyasu Iso, Youichi Kurozawa, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh. Feelings about pregnancy and mother-infant bonding as predictors of persistent psychological distress in the perinatal period: The Japan Environment and Children's Study. Journal of Psychiatric Research. 2021; 140 ():132-140.

Chicago/Turabian Style

Narumi Tokuda; Yoshiko Kobayashi; Hiroyuki Tanaka; Hideaki Sawai; Hiroaki Shibahara; Yasuhiro Takeshima; Masayuki Shima; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Takeo Nakayama; Hiroyasu Iso; Youichi Kurozawa; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh. 2021. "Feelings about pregnancy and mother-infant bonding as predictors of persistent psychological distress in the perinatal period: The Japan Environment and Children's Study." Journal of Psychiatric Research 140, no. : 132-140.

Journal article
Published: 29 May 2021 in Allergology International
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Wheezing is a common symptom in infants, which may occasionally develop into asthma. There are many factors related to infant wheezing, including anatomical features, viral infections, and passive smoking. There are only a few reports on the association between renovation and pregnancy worldwide, and reports on this association are inadequate in Japan. This study aimed to examine the association between house renovation and new construction during pregnancy and wheezing in infants during the first year of life using data from the Japan Environment and Children's Study (JECS). Data of pregnant women registered in JECS were collected using self-administered questionnaires during the second/third trimester and 1 month after delivery. Childbirth records were completed by the doctors. Similarly, wheezing in infants was evaluated using self-administered questionnaires 1 year after birth. Logistic regression analysis was used to determine the primary outcome. In total, 75,731 infants, excluding those with unknown gender, who were not singleton infants, and who relocated during pregnancy and the first month of life, were examined in this study. Renovation during pregnancy increased the prevalence of wheezing (odds ratio [OR]: 1.33, 95% confidence interval [CI]: 1.20–1.48) and recurrent wheezing (OR: 1.22, 95% CI: 1.00–1.48) in the first year of life. The relationship between new construction during pregnancy and wheezing in infants was insignificant (OR: 0.98, 95% CI: 0.90–1.06). Renovation during pregnancy may be a risk factor for wheezing in infants, and should be avoided.

ACS Style

Tetsuro Fujino; Hideki Hasunuma; Masumi Okuda; Midori Saito; Takeshi Utsunomiya; Yohei Taniguchi; Naoko Taniguchi; Masayuki Shima; Yasuhiro Takeshima; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Takeo Nakayama; Hiroyasu Iso; Youichi Kurozawa; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh. Association between house renovation during pregnancy and wheezing in the first year of life: The Japan environment and children's study. Allergology International 2021, 1 .

AMA Style

Tetsuro Fujino, Hideki Hasunuma, Masumi Okuda, Midori Saito, Takeshi Utsunomiya, Yohei Taniguchi, Naoko Taniguchi, Masayuki Shima, Yasuhiro Takeshima, Michihiro Kamijima, Shin Yamazaki, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Takeo Nakayama, Hiroyasu Iso, Youichi Kurozawa, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh. Association between house renovation during pregnancy and wheezing in the first year of life: The Japan environment and children's study. Allergology International. 2021; ():1.

Chicago/Turabian Style

Tetsuro Fujino; Hideki Hasunuma; Masumi Okuda; Midori Saito; Takeshi Utsunomiya; Yohei Taniguchi; Naoko Taniguchi; Masayuki Shima; Yasuhiro Takeshima; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Takeo Nakayama; Hiroyasu Iso; Youichi Kurozawa; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh. 2021. "Association between house renovation during pregnancy and wheezing in the first year of life: The Japan environment and children's study." Allergology International , no. : 1.

Regular article
Published: 18 January 2021 in Psychiatry and Clinical Neurosciences
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Aim Patients with major depression present with an increased serum insulin‐like growth factor‐1 (IGF‐1) concentration. However, the longitudinal relationship between serum IGF‐1 levels and depression development remains unclear. This study aimed to investigate the longitudinal association between the serum IGF‐1 concentration in the first trimester of pregnancy and postpartum depression development using data obtained from the Japan Environment and Children's Study (JECS). Methods The JECS included 97,415 pregnant women; among them, 8,791 were enrolled in this study. Data regarding depression in the first trimester, postpartum depression development at one month after childbirth, and other covariates were collected using a self‐administered questionnaire. Serum IGF‐1 levels were measured in the first trimester of pregnancy. The participants were divided into four groups according to the serum IGF‐1 level. Results In the first trimester, serum IGF‐1 levels were not significantly associated with psychological distress in pregnant women. In the longitudinal analyses, however, postpartum depression development in mothers within the highest quartile for serum IGF‐1 concentration in the first trimester was significantly less common than in those within the lowest quartile (odds ratio 0.48, 95% confidence interval 0.30–0.79). Conclusion Pregnant women with a high serum IGF‐1 concentration in the first trimester were less likely to develop postpartum depression than those with a low concentration. A high serum IGF‐1 concentration during pregnancy may help to protect against postpartum depression development.

ACS Style

Sho Adachi; Narumi Tokuda; Yoshiko Kobayashi; Hiroyuki Tanaka; Hideaki Sawai; Hiroaki Shibahara; Yasuhiro Takeshima; Masayuki Shima; the Japan Environment and Children's Study Group. Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression. Psychiatry and Clinical Neurosciences 2021, 75, 159 -165.

AMA Style

Sho Adachi, Narumi Tokuda, Yoshiko Kobayashi, Hiroyuki Tanaka, Hideaki Sawai, Hiroaki Shibahara, Yasuhiro Takeshima, Masayuki Shima, the Japan Environment and Children's Study Group. Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression. Psychiatry and Clinical Neurosciences. 2021; 75 (5):159-165.

Chicago/Turabian Style

Sho Adachi; Narumi Tokuda; Yoshiko Kobayashi; Hiroyuki Tanaka; Hideaki Sawai; Hiroaki Shibahara; Yasuhiro Takeshima; Masayuki Shima; the Japan Environment and Children's Study Group. 2021. "Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression." Psychiatry and Clinical Neurosciences 75, no. 5: 159-165.

Journal article
Published: 22 August 2020 in Journal of Infection and Chemotherapy
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IntroductionAntibody tests for detecting varicella-zoster virus include the fluorescent-antibody-to-membrane-antigen (FAMA) assay, immune adherence hemagglutination assay (IAHA), enzyme immunoassay (EIA), and the glycoprotein-based enzyme-linked immunosorbent assay (gpELISA). Although FAMA and gpELISA are highly sensitive, FAMA is not available commercially. Therefore, this study was performed to compare potential high-sensitivity tests with commercially available tests.MethodsFour antibody tests, FAMA, gpELISA, EIA, and IAHA, were performed using sera collected from 32 children aged 7 months–10 years. Using FAMA as a reference, the sensitivity and specificity of gpELISA, EIA, and IAHA were assessed. Subsequently, using gpELISA as a reference, the positive agreement rate of EIA and IAHA was assessed.ResultsOn a reference scale with FAMA set at 100%, the sensitivity and specificity of the antibody tests were as follows: gpELISA, 67% and 100%; EIA, 67% and 100%; and IAHA, 47% and 100%, respectively. The positive agreement rates of EIA and IAHA relative to gpELISA were 86% and 64%, respectively.Conclusions: gpELISA had a lower positive rate than did FAMA, and showed comparable sensitivity to that of EIA.

ACS Style

Naruhito Otani; Masayuki Shima; Susumu Tanimura; Takashi Ueda; Kaoru Ichiki; Kazuhiko Nakajima; Yoshio Takesue; Kenta Honjo; Toshiomi Okuno. Sensitivity and specificity of different antibody tests for detecting varicella-zoster virus. Journal of Infection and Chemotherapy 2020, 26, 1 .

AMA Style

Naruhito Otani, Masayuki Shima, Susumu Tanimura, Takashi Ueda, Kaoru Ichiki, Kazuhiko Nakajima, Yoshio Takesue, Kenta Honjo, Toshiomi Okuno. Sensitivity and specificity of different antibody tests for detecting varicella-zoster virus. Journal of Infection and Chemotherapy. 2020; 26 (12):1.

Chicago/Turabian Style

Naruhito Otani; Masayuki Shima; Susumu Tanimura; Takashi Ueda; Kaoru Ichiki; Kazuhiko Nakajima; Yoshio Takesue; Kenta Honjo; Toshiomi Okuno. 2020. "Sensitivity and specificity of different antibody tests for detecting varicella-zoster virus." Journal of Infection and Chemotherapy 26, no. 12: 1.

Journal article
Published: 25 July 2020 in Environmental Health and Preventive Medicine
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The neurotoxicity of general anesthesia to the developing human brains is controversial. We assessed the associations between surgery under general anesthesia in infancy and development at age 1 year using the Japan Environment and Children’s Study (JECS), a large-scale birth cohort study. In the JECS, 103,062 pregnancies and 104,065 fetuses were enrolled between January 2011 and March 2014. Of the 100,144 registered live births, we excluded preterm or post-term infants, multiple births, and infants with chromosomal anomalies and/or anomalies of the head or brain. Data on surgical procedures under general anesthesia in infancy were collected from self-administered questionnaires by parents at the 1-year follow-up. Developmental delay at age 1 year was assessed using the Japanese translation of the Ages and Stages Questionnaires, Third Edition (J-ASQ-3), comprising five developmental domains. Among the 64,141 infants included, 746 infants had surgery under general anesthesia once, 90 twice, and 71 three or more times. The percentage of developmental delay in the five domains of the J-ASQ-3 significantly increased with the number of surgical procedures. After adjusting for potential confounding factors, the risk of developmental delays in all five domains was significantly increased in infants who had surgery under general anesthesia three times or more (adjusted odds ratios: for communication domain 3.32; gross motor domain 4.69; fine motor domain 2.99; problem solving domain 2.47; personal–social domain 2.55). Surgery under general anesthesia in infancy was associated with an increased likelihood of developmental delay in all five domains of the J-ASQ-3, especially the gross motor domain at age 1 year. The neurodevelopment with the growth should be further evaluated among the children who had surgery under general anesthesia. UMIN Clinical Trials Registry (number: UMIN000030786)

ACS Style

Yoshiko Kobayashi; Japan Environment and Children’s Study (JECS) Group; Narumi Tokuda; Sho Adachi; Yasuhiro Takeshima; Munetaka Hirose; Masayuki Shima. Association between surgical procedures under general anesthesia in infancy and developmental outcomes at 1 year: the Japan Environment and Children’s Study. Environmental Health and Preventive Medicine 2020, 25, 1 -10.

AMA Style

Yoshiko Kobayashi, Japan Environment and Children’s Study (JECS) Group, Narumi Tokuda, Sho Adachi, Yasuhiro Takeshima, Munetaka Hirose, Masayuki Shima. Association between surgical procedures under general anesthesia in infancy and developmental outcomes at 1 year: the Japan Environment and Children’s Study. Environmental Health and Preventive Medicine. 2020; 25 (1):1-10.

Chicago/Turabian Style

Yoshiko Kobayashi; Japan Environment and Children’s Study (JECS) Group; Narumi Tokuda; Sho Adachi; Yasuhiro Takeshima; Munetaka Hirose; Masayuki Shima. 2020. "Association between surgical procedures under general anesthesia in infancy and developmental outcomes at 1 year: the Japan Environment and Children’s Study." Environmental Health and Preventive Medicine 25, no. 1: 1-10.

Journal article
Published: 23 May 2020 in International Journal of Environmental Research and Public Health
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Air purifiers have become popular among ordinary families. However, it remains controversial whether indoor air purification improves the respiratory health of healthy adults. A randomized crossover intervention study was conducted with 32 healthy individuals. The subjects were categorized into two groups. One group continuously used true air purifiers, and the other followed with sham air purifiers for 4 weeks. Following this first intervention, all the subjects underwent a 4-week washout period and continued with the second 4-week intervention with the alternate air purifiers. We collected fine particulate matter (PM) ≤ 2.5 µm in aerodynamic diameter (PM2.5), coarse particulate matter between 2.5 and 10 µm in aerodynamic diameter (PM10–2.5) and ozone (O3). The subjects’ pulmonary function and fractional exhaled nitric oxide (FeNO) were measured during the study period. The indoor PM2.5 concentrations decreased by 11% with the true air purifiers compared to those with sham air purifiers. However, this decrease was not significant (p = 0.08). The air purification did not significantly improve the pulmonary function of the study subjects. In contrast, an increase in the indoor PM10–2.5 and O3 concentration led to a significant decrease in the forced expiratory volume in one second (FEV1.0)/forced vital capacity (FVC) and maximal mid-expiratory flow (MMEF), respectively. In conclusion, air purification slightly improved the indoor PM2.5 concentrations in ordinary homes but had no demonstrable impact on improving health.

ACS Style

Yoshiko Yoda; Kenji Tamura; Sho Adachi; Naruhito Otani; Shoji F. Nakayama; Masayuki Shima. Effects of the Use of Air Purifier on Indoor Environment and Respiratory System among Healthy Adults. International Journal of Environmental Research and Public Health 2020, 17, 3687 .

AMA Style

Yoshiko Yoda, Kenji Tamura, Sho Adachi, Naruhito Otani, Shoji F. Nakayama, Masayuki Shima. Effects of the Use of Air Purifier on Indoor Environment and Respiratory System among Healthy Adults. International Journal of Environmental Research and Public Health. 2020; 17 (10):3687.

Chicago/Turabian Style

Yoshiko Yoda; Kenji Tamura; Sho Adachi; Naruhito Otani; Shoji F. Nakayama; Masayuki Shima. 2020. "Effects of the Use of Air Purifier on Indoor Environment and Respiratory System among Healthy Adults." International Journal of Environmental Research and Public Health 17, no. 10: 3687.

Journal article
Published: 31 March 2020 in Environmental Pollution
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Natural aeolian dust (AD) particles are potential carriers of polycyclic aromatic hydrocarbons (PAHs) in the atmosphere. The heterogeneous interaction between them may lead to worsened air quality and enhanced cytotoxicity and carcinogenicity of ambient particulates in downwind areas, and this topic requires in-depth exploration. In this study, AD samples were collected from four Asian dust sources, and their physical properties and compositions were determined, showing great regional differences. The physical and chemical interactions of different AD particles with naphthalene (Nap; model PAH) were observed in aqueous systems. The results showed that AD particles from the Loess Plateau had weak adsorption to Nap, which was fitted by the Langmuir isotherm. There was no obvious adsorption to Nap found for the other three AD samples. This difference seemed to depend mainly on the specific surface area and/or the total pore volume. In addition, the Nap in the aqueous solution did not undergo chemical reactions under dark conditions and longwave ultraviolet (UV) radiation but degraded under shortwave UV radiation, and 2-formylcinnamaldehyde and 1,4-naphthoquinone were the first-generated products. The degradation of Nap in the aqueous solution was probably initiated by photoionization, and the reaction rate constant (between 1.44 × 10−4 min−1 and 8.55 × 10−4 min−1) was much lower than that of Nap with hydroxyl radicals. Instead of inducing or promoting the chemical change in Nap, the AD particles slowed photodegradation due to the extinction of radiation. Therefore, it is inferred that natural AD particles have no substantial effect on the transportation and transformation of PAHs in the atmosphere.

ACS Style

Lulu Zhang; Xuan Zhang; Wanli Xing; Quanyu Zhou; Lu Yang; Ryohei Nakatsubo; Yongjie Wei; Jianrong Bi; Masayuki Shima; Akira Toriba; Kazuichi Hayakawa; Ning Tang. Natural aeolian dust particles have no substantial effect on atmospheric polycyclic aromatic hydrocarbons (PAHs): A laboratory study based on naphthalene. Environmental Pollution 2020, 263, 114454 .

AMA Style

Lulu Zhang, Xuan Zhang, Wanli Xing, Quanyu Zhou, Lu Yang, Ryohei Nakatsubo, Yongjie Wei, Jianrong Bi, Masayuki Shima, Akira Toriba, Kazuichi Hayakawa, Ning Tang. Natural aeolian dust particles have no substantial effect on atmospheric polycyclic aromatic hydrocarbons (PAHs): A laboratory study based on naphthalene. Environmental Pollution. 2020; 263 ():114454.

Chicago/Turabian Style

Lulu Zhang; Xuan Zhang; Wanli Xing; Quanyu Zhou; Lu Yang; Ryohei Nakatsubo; Yongjie Wei; Jianrong Bi; Masayuki Shima; Akira Toriba; Kazuichi Hayakawa; Ning Tang. 2020. "Natural aeolian dust particles have no substantial effect on atmospheric polycyclic aromatic hydrocarbons (PAHs): A laboratory study based on naphthalene." Environmental Pollution 263, no. : 114454.

Journal article
Published: 02 December 2019 in Science of The Total Environment
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PM2.5 samples were collected inside and outside a primary school classroom in Beijing in 2015 and analysed for 11 polycyclic aromatic hydrocarbons (PAHs) and 10 nitro-PAHs (NPAHs). In the sampling period in the heating season (namely, the heating period), the median concentrations of indoor and outdoor PAHs were 223 ng/m3 and 264 ng/m3, respectively, and those of indoor and outdoor NPAHs were 3.61 ng/m3 and 5.12 ng/m3, respectively. The concentrations of PAHs and NPAHs were consistently higher in the heating period than those (indoor PAHs: 8.75 ng/m3, outdoor PAHs: 8.95 ng/m3, indoor NPAHs: 0.25 ng/m3, outdoor NPAHs: 0.40 ng/m3) in the sampling period in the non-heating season (namely, the non-heating period). In both periods, total PAHs and total NPAHs in indoor PM2.5, as well as most individual PAHs and NPAHs, were positively correlated with the outdoor PAH and NPAH concentrations (p < 0.05). This finding suggests that indoor PAHs and NPAHs are largely dependent on outdoor inputs. It is inferred from the diagnostic ratios that PAHs and NPAHs in indoor and outdoor PM2.5 were affected jointly by coal combustion and vehicular emission in the heating period and mainly derived from vehicle exhaust in the non-heating period. Both indoor and outdoor PM2.5 showed considerable benzo[a]pyrene equivalent toxicity (BaPeq), especially in the heating period. Benzo[c]fluorene (BcFE) had relatively low concentrations but large contributions to BaPeq in both periods. This is the first report of PM2.5-bound BcFE inside and outside classrooms in Beijing. This result indicates that neglecting PAHs with low abundance but high toxicity leads to a significant underestimation of the overall PAH toxicity. The inhalation cancer risk (CR) of PAHs and NPAHs in PM2.5 during the primary school year exceeded the acceptable level as defined by the U.S. EPA, emphasizing its impact on the lifetime CR in schoolchildren.

ACS Style

Lulu Zhang; Hiroshi Morisaki; Yongjie Wei; Zhigang Li; Lu Yang; Quanyu Zhou; Xuan Zhang; Wanli Xing; Min Hu; Masayuki Shima; Akira Toriba; Kazuichi Hayakawa; Ning Tang. PM2.5-bound polycyclic aromatic hydrocarbons and nitro-polycyclic aromatic hydrocarbons inside and outside a primary school classroom in Beijing: Concentration, composition, and inhalation cancer risk. Science of The Total Environment 2019, 705, 135840 .

AMA Style

Lulu Zhang, Hiroshi Morisaki, Yongjie Wei, Zhigang Li, Lu Yang, Quanyu Zhou, Xuan Zhang, Wanli Xing, Min Hu, Masayuki Shima, Akira Toriba, Kazuichi Hayakawa, Ning Tang. PM2.5-bound polycyclic aromatic hydrocarbons and nitro-polycyclic aromatic hydrocarbons inside and outside a primary school classroom in Beijing: Concentration, composition, and inhalation cancer risk. Science of The Total Environment. 2019; 705 ():135840.

Chicago/Turabian Style

Lulu Zhang; Hiroshi Morisaki; Yongjie Wei; Zhigang Li; Lu Yang; Quanyu Zhou; Xuan Zhang; Wanli Xing; Min Hu; Masayuki Shima; Akira Toriba; Kazuichi Hayakawa; Ning Tang. 2019. "PM2.5-bound polycyclic aromatic hydrocarbons and nitro-polycyclic aromatic hydrocarbons inside and outside a primary school classroom in Beijing: Concentration, composition, and inhalation cancer risk." Science of The Total Environment 705, no. : 135840.

Journal article
Published: 01 December 2019 in The Lancet Planetary Health
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Declining proportions of male births have been reported in several industrialised countries. Previous reports have shown that exposure to certain chemical substances might influence the secondary sex ratio (SSR). We assessed the associations between paternal occupational exposure to chemicals and the SSR of their children using the Japan Environment and Children's Study (JECS), a large-scale birth cohort study. Data on paternal occupational exposure to various agents and other covariates were collected using a self-administered questionnaire to partners of pregnant female participants enrolled in the JECS. After adjusting for potential confounders, multivariable modified Poisson regression models were used to evaluate associations between paternal occupational exposures and the SSR of their children. This study was registered in the UMIN Clinical Trials Registry, number UMIN000030786. The JECS study gathered data on 103 062 pregnancies, 104 065 fetuses, and 51 898 partners of pregnant women. Among 50 283 children with data on paternal occupational exposures, 25 657 were male and 24 626 were female. The proportion of boys whose fathers were regularly occupationally exposed to insecticides was 0·445 (males, n=293; females, n=366; 95% CI 0·406-0·483), which was lower than the proportion of boys whose fathers were not exposed to insecticides. After adjusting for confounding factors, regular paternal occupational exposure to insecticides (adjusted relative risk 0·86, 95% CI 0·78-0·96) and medical disinfectants (0·95, 0·90-1·00) were significantly associated with lower SSRs among their offspring compared with the offspring of fathers not exposed to these substances. A declining proportion of boys could potentially be due to fathers working in environments in which they are exposed to chemicals. The associations between poorer semen quality and levels of reproductive and thyroid hormones require investigation. Ministry of the Environment of Japan.

ACS Style

Sho Adachi; Junko Sawaki; Narumi Tokuda; Hiroyuki Tanaka; Hideaki Sawai; Yasuhiro Takeshima; Hiroaki Shibahara; Masayuki Shima; Japan Environment And Children's Study Group. Paternal occupational exposure to chemicals and secondary sex ratio: results from the Japan Environment and Children's Study. The Lancet Planetary Health 2019, 3, e529 -e538.

AMA Style

Sho Adachi, Junko Sawaki, Narumi Tokuda, Hiroyuki Tanaka, Hideaki Sawai, Yasuhiro Takeshima, Hiroaki Shibahara, Masayuki Shima, Japan Environment And Children's Study Group. Paternal occupational exposure to chemicals and secondary sex ratio: results from the Japan Environment and Children's Study. The Lancet Planetary Health. 2019; 3 (12):e529-e538.

Chicago/Turabian Style

Sho Adachi; Junko Sawaki; Narumi Tokuda; Hiroyuki Tanaka; Hideaki Sawai; Yasuhiro Takeshima; Hiroaki Shibahara; Masayuki Shima; Japan Environment And Children's Study Group. 2019. "Paternal occupational exposure to chemicals and secondary sex ratio: results from the Japan Environment and Children's Study." The Lancet Planetary Health 3, no. 12: e529-e538.

Journal article
Published: 07 August 2019 in International Journal of Environmental Research and Public Health
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Particulate matter (PM) was collected in three different areas, SY-1, SY-2, and SY-3, in Shenyang, China, during the warm and cold seasons from 2012 to 2014. SY-1 was located beside a thermal power plant, far from the central area. SY-2 was near a coal heating boiler on the main road, close to the central area. SY-3 was on the main road, without fixed emission sources. Nine PM-bound polycyclic aromatic hydrocarbons (PAHs) were analyzed. The results showed that the mean concentration of total PAHs was higher in the cold season (92.6-316 ng m-3) than in the warm season (18.4-32.2 ng m-3). Five- and six-ring PAHs occupied a large percentage at all sites in the warm season, and four-ring PAHs were the dominant components in the cold season. Several diagnostic PAH ratios indicated that the main sources of PAHs in Shenyang in the warm and cold seasons were not only coal burning but also vehicle emission. In this study, we suggest that a benzo[a]pyrene/benzo[ghi]perylene ratio ([BaP]/[BgPe]) of 0.6 was a useful indicator to speculate the relative significance of coal burning and vehicle exhaust. Although the Shenyang government has undertaken actions to address air pollution, the PM and PAH concentrations did not decrease significantly compared to those in our previous studies. The cancer risk calculated from the BaP equivalent total concentration at all three sites in the warm and cold seasons exceeded the acceptable limit established by the US EPA.

ACS Style

Lu Yang; Genki Suzuki; Lulu Zhang; Quanyu Zhou; Xuan Zhang; Wanli Xing; Masayuki Shima; Yoshiko Yoda; Ryohei Nakatsubo; Takatoshi Hiraki; Baijun Sun; Wenhua Fu; Hongye Qi; Kazuichi Hayakawa; Akira Toriba; Ning Tang. The Characteristics of Polycyclic Aromatic Hydrocarbons in Different Emission Source Areas in Shenyang, China. International Journal of Environmental Research and Public Health 2019, 16, 2817 .

AMA Style

Lu Yang, Genki Suzuki, Lulu Zhang, Quanyu Zhou, Xuan Zhang, Wanli Xing, Masayuki Shima, Yoshiko Yoda, Ryohei Nakatsubo, Takatoshi Hiraki, Baijun Sun, Wenhua Fu, Hongye Qi, Kazuichi Hayakawa, Akira Toriba, Ning Tang. The Characteristics of Polycyclic Aromatic Hydrocarbons in Different Emission Source Areas in Shenyang, China. International Journal of Environmental Research and Public Health. 2019; 16 (16):2817.

Chicago/Turabian Style

Lu Yang; Genki Suzuki; Lulu Zhang; Quanyu Zhou; Xuan Zhang; Wanli Xing; Masayuki Shima; Yoshiko Yoda; Ryohei Nakatsubo; Takatoshi Hiraki; Baijun Sun; Wenhua Fu; Hongye Qi; Kazuichi Hayakawa; Akira Toriba; Ning Tang. 2019. "The Characteristics of Polycyclic Aromatic Hydrocarbons in Different Emission Source Areas in Shenyang, China." International Journal of Environmental Research and Public Health 16, no. 16: 2817.

Journal article
Published: 26 June 2019 in International Journal of Environmental Research and Public Health
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Objectives: To explore the health effects of indoor/outdoor carbonaceous compositions in PM2.5 on pulmonary function among healthy students living in the local university campus. Methods: Daily peak expiratory flow (PEF) and forced expiratory volume in 1 second (FEV1) were measured among 37 healthy students in the morning and evening for four two-week periods. Concurrent concentrations of indoor and outdoor PM2.5 (particulate matter with an aerodynamic diameter ≤ 2.5m), carbonaceous components in PM2.5, ambient temperature, and relative humidity in the study area were also obtained. Mixed-effects model was applied to evaluate the associations between carbonaceous components and lung function. Different lags for the carbonaceous components were investigated. Results: In single-pollutant model, a 10 g/m3 increase of indoor and outdoor EC (elemental carbon) associated with −3.93 (95%CI: −6.89, −0.97) L/min and −3.21 (95%CI: −5.67, −0.75) L/min change in evening PEF at lag 0 day, respectively. Also, a 10 g/m3 increase of indoor and outdoor POC (primary organic carbon) concentration was significantly associated with −5.82 (95%CI: −10.82, −0.81) L/min and −7.32 (95%CI: −12.93, −1.71) L/min change of evening PEF at lag 0 day. After adjusting total mass of PM2.5, indoor EC consistently had a significant adverse impact on evening PEF and FEV1 at lag3 day and a cumulative effect at lag0-3 day. Conclusions: This study suggests that carbonaceous components in PM2.5 indeed have impacts on pulmonary function among healthy young adults especially on evening PEF. Thus, the local mitigation strategies on pollution are needed.

ACS Style

Shichun Huang; Huan Feng; Shanshan Zuo; Jingling Liao; Mingquan He; Masayuki Shima; Kenji Tamura; Yang Li; Lu Ma. Short-Term Effects of Carbonaceous Components in PM2.5 on Pulmonary Function: A Panel Study of 37 Chinese Healthy Adults. International Journal of Environmental Research and Public Health 2019, 16, 2259 .

AMA Style

Shichun Huang, Huan Feng, Shanshan Zuo, Jingling Liao, Mingquan He, Masayuki Shima, Kenji Tamura, Yang Li, Lu Ma. Short-Term Effects of Carbonaceous Components in PM2.5 on Pulmonary Function: A Panel Study of 37 Chinese Healthy Adults. International Journal of Environmental Research and Public Health. 2019; 16 (13):2259.

Chicago/Turabian Style

Shichun Huang; Huan Feng; Shanshan Zuo; Jingling Liao; Mingquan He; Masayuki Shima; Kenji Tamura; Yang Li; Lu Ma. 2019. "Short-Term Effects of Carbonaceous Components in PM2.5 on Pulmonary Function: A Panel Study of 37 Chinese Healthy Adults." International Journal of Environmental Research and Public Health 16, no. 13: 2259.

Journal article
Published: 18 April 2019 in Science of The Total Environment
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Previous studies have reported the short-term effects of particulate air pollution on health. However, most of those studies were relatively short in duration, with only a few, in healthy adolescents. We investigated the short-term effects of particulate air pollution on pulmonary function in healthy adolescents over a long period. A panel study was repeatedly conducted twice a year for about one month each, in spring and fall from 2014 to 2016, in an isolated island in the Seto Inland Sea, Japan. Daily measurements of peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) were performed in a total of 48 healthy college students aged 15–19 years. The ambient concentrations of particulate matter with diameter ≤2.5 μm (PM2.5) and between 2.5 and 10 μm (PM10–2.5), and black carbon (BC) were continuously measured. A mixed-effects model was used to investigate the relationships between air pollutants and pulmonary function. In the overall analyses of the six study periods, decreases in the PEF and FEV1 were significantly associated with increases in the PM2.5 and BC concentrations. The greatest decrease was found in FEV1 (−1.97% [95% confidence interval (CI): −2.90, −1.04]), which was associated with an interquartile range (IQR) increase in the 0–72-h average concentrations of PM2.5 (14.1 μg/m3). Neither PEF nor FEV1 were associated with PM10–2.5 concentrations. In the analyses by season, both the PEF and FEV1 values decreased significantly in relation to increases in the PM2.5, PM10–2.5 and BC concentrations in the fall. However, in spring, both PEF and FEV1 showed weak associations with each of the pollutants. In conclusion, relatively low increases in the ambient particulate matter levels were associated with reduced pulmonary function among healthy adolescents. This association was stronger in fall than in spring.

ACS Style

Yoshiko Yoda; Hiroshi Takagi; Junko Wakamatsu; Takeshi Ito; Ryohei Nakatsubo; Yosuke Horie; Takatoshi Hiraki; Masayuki Shima. Stronger association between particulate air pollution and pulmonary function among healthy students in fall than in spring. Science of The Total Environment 2019, 675, 483 -489.

AMA Style

Yoshiko Yoda, Hiroshi Takagi, Junko Wakamatsu, Takeshi Ito, Ryohei Nakatsubo, Yosuke Horie, Takatoshi Hiraki, Masayuki Shima. Stronger association between particulate air pollution and pulmonary function among healthy students in fall than in spring. Science of The Total Environment. 2019; 675 ():483-489.

Chicago/Turabian Style

Yoshiko Yoda; Hiroshi Takagi; Junko Wakamatsu; Takeshi Ito; Ryohei Nakatsubo; Yosuke Horie; Takatoshi Hiraki; Masayuki Shima. 2019. "Stronger association between particulate air pollution and pulmonary function among healthy students in fall than in spring." Science of The Total Environment 675, no. : 483-489.

Journal article
Published: 07 February 2019 in Allergology International
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Background Few papers have examined the association between the chemical components of PM2.5 and health effects. The existence of an association is now under discussion. Methods This case-crossover study aimed to examine the association between the chemical components of PM2.5 and night-time primary care visits (PCVs) due to asthma attacks. The subjects were 1251 children aged 0–14 years who received medical care for asthma at a municipal emergency clinic. We measured daily average concentrations of hydrogen ion, sulfate ion, nitrate ion and water-soluble organic compounds (WSOCs), which are components of PM2.5. We estimated the odds ratios (ORs) of PCVs per unit increment (inter quartile ranges) in each chemical component of PM2.5 for the subgroups of warmer months and colder months separately. Results No association was seen between PCVs and PM2.5 mass concentrations the day before the PCVs in either warmer or colder months. In the warmer months, an association was seen with the concentrations of WSOCs and hydrogen ion the day before the PCVs (OR = 1.33; 95% CI: 1.00–1.76, OR = 1.18; 95% CI: 1.02–1.36, respectively). Furthermore, a negative association was seen between sulfate ion and PCVs (OR = 0.85; 95%CI: 0.74–0.98). No associations were observed in the colder months. Conclusions We observed a positive association between PCVs and certain concentrations of WSOCs and hydrogen ions in warmer months. In contrast, sulfate ion showed a negative association.

ACS Style

Shin Yamazaki; Masayuki Shima; Yoshiko Yoda; Fumitake Kurosaka; Toshio Isokawa; Shigeta Shimizu; Teruhiro Ogawa; Naohiro Kamiyoshi; Kunihiko Terada; Jittoku Nishikawa; Kenji Hanaoka; Taku Yamada; Shinro Matsuura; Akihiro Hongo; Ichiro Yamamoto. Association between chemical components of PM2.5 and children's primary care night-time visits due to asthma attacks: A case-crossover study. Allergology International 2019, 68, 329 -334.

AMA Style

Shin Yamazaki, Masayuki Shima, Yoshiko Yoda, Fumitake Kurosaka, Toshio Isokawa, Shigeta Shimizu, Teruhiro Ogawa, Naohiro Kamiyoshi, Kunihiko Terada, Jittoku Nishikawa, Kenji Hanaoka, Taku Yamada, Shinro Matsuura, Akihiro Hongo, Ichiro Yamamoto. Association between chemical components of PM2.5 and children's primary care night-time visits due to asthma attacks: A case-crossover study. Allergology International. 2019; 68 (3):329-334.

Chicago/Turabian Style

Shin Yamazaki; Masayuki Shima; Yoshiko Yoda; Fumitake Kurosaka; Toshio Isokawa; Shigeta Shimizu; Teruhiro Ogawa; Naohiro Kamiyoshi; Kunihiko Terada; Jittoku Nishikawa; Kenji Hanaoka; Taku Yamada; Shinro Matsuura; Akihiro Hongo; Ichiro Yamamoto. 2019. "Association between chemical components of PM2.5 and children's primary care night-time visits due to asthma attacks: A case-crossover study." Allergology International 68, no. 3: 329-334.

Comparative study
Published: 10 January 2019 in Environmental Health and Preventive Medicine
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Over the past few decades, the Japanese Ministry of the Environment has been biomonitoring dioxins in the general Japanese population and, in response to public concerns, has taken measures to reduce dioxin exposure. The objectives of this study were to assess the current dioxin dietary intake and corresponding body burden in the Japanese and compare Japanese dioxin data from 2011 to 2016 and 2002–2010 surveys. We also examined the relationship between blood dioxins and health parameters/clinical biomarkers. From 2011 to 2016, cross-sectional dioxin surveys were conducted on 490 Japanese (242 males and 248 females, aged 49.9 ± 7.6 years) from 15 Japanese prefectures. Blood (n = 490) and food samples (n = 90) were measured for 29 dioxin congeners including polychlorinated dibenzo-para-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (Co-PCBs) using gas chromatography coupled with high-resolution mass spectrometry. Using the 2006 World Health Organization toxic equivalence factors, the toxic equivalents (TEQs) were calculated. Clinical biomarkers and anthropometric parameters were also measured and information on lifestyle behaviours collected. Data imputations were applied to account for blood dioxins below the detection limit. The median (95% confidence interval or CI) blood levels and dioxin dietary intake was respectively 9.4 (8.8–9.9) pg TEQ/g lipid and 0.3 (0.2–0.4) pg TEQ/kg body weight/day. The median blood dioxin level in the 2011–2016 survey was found to have decreased by 41.3% compared to the 2002–2010 surveys. Participants who were older were found to be more likely to have higher dioxin levels. Blood dioxins were also significantly associated with body mass index, triglycerides, docosahexaenoic acid, eicosapentaenoic acid, and dihomo-gamma-linoleic acid levels in blood. Furthermore, associations between blood dioxin and dietary dioxin intake were evident in the unadjusted models. However, after adjusting for confounders, blood dioxins were not found to be associated with dietary dioxin intake. Blood dioxin levels declined over the past decade. This study showed that the measures and actions undertaken in Japan have possibly contributed to these reductions in the body burden of dioxins in the Japanese population.

ACS Style

Basilua Andre Muzembo; Miyuki Iwai-Shimada; Tomohiko Isobe; Kokichi Arisawa; Masayuki Shima; Tetsuhito Fukushima; Shoji F. Nakayama. Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan. Environmental Health and Preventive Medicine 2019, 24, 6 .

AMA Style

Basilua Andre Muzembo, Miyuki Iwai-Shimada, Tomohiko Isobe, Kokichi Arisawa, Masayuki Shima, Tetsuhito Fukushima, Shoji F. Nakayama. Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan. Environmental Health and Preventive Medicine. 2019; 24 (1):6.

Chicago/Turabian Style

Basilua Andre Muzembo; Miyuki Iwai-Shimada; Tomohiko Isobe; Kokichi Arisawa; Masayuki Shima; Tetsuhito Fukushima; Shoji F. Nakayama. 2019. "Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan." Environmental Health and Preventive Medicine 24, no. 1: 6.

Original article
Published: 07 January 2019 in Cancer Science
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Occupational asbestos exposure occurs in many workplaces and is a well‐known cause of mesothelioma and lung cancer. However, the association between nonoccupational asbestos exposure and those diseases is not clearly described. The aim of this study was to investigate cause‐specific mortality among the residents of Amagasaki, a city in Japan with many asbestos factories, and evaluate the potential excess mortality due to established and suspected asbestos‐related diseases. The study population consisted of 143 929 residents in Amagasaki City before 1975 until 2002, aged 40 years or older on January 1, 2002. Follow‐up was carried out from 2002 to 2015. Standardized mortality ratio (SMR) with its 95% confidence interval (CI) was calculated by sex, using the mortality rate of the Japanese population as reference. A total of 38 546 deaths (including 303 from mesothelioma and 2683 from lung cancer) were observed. The SMRs in the long‐term residents’ cohort were as follows: death due to all causes, 1.12 (95% CI, 1.10‐1.13) in men and 1.07 (95% CI, 1.06‐1.09) in women; lung cancer, 1.28 (95% CI, 1.23‐1.34) in men and 1.23 (95% CI, 1.14‐1.32) in women; and mesothelioma, 6.75 (95% CI, 5.83‐7.78) in men and 14.99 (95% CI, 12.34‐18.06) in women. These SMRs were significantly higher than expected. The increased SMR of mesothelioma suggests the impact of occupational asbestos exposure among men and nonoccupational asbestos exposure among women in the long‐term residents’ cohort. In addition, the high level of excess mortality from mesothelioma has persisted, despite the mixture of crocidolite and chrysotile no longer being used for three or four decades.

ACS Style

Ling Zha; Yuri Kitamura; Tetsuhisa Kitamura; Rong Liu; Masayuki Shima; Norio Kurumatani; Tomoki Nakaya; Junko Goji; Tomotaka Sobue. Population‐based cohort study on health effects of asbestos exposure in Japan. Cancer Science 2019, 110, 1076 -1084.

AMA Style

Ling Zha, Yuri Kitamura, Tetsuhisa Kitamura, Rong Liu, Masayuki Shima, Norio Kurumatani, Tomoki Nakaya, Junko Goji, Tomotaka Sobue. Population‐based cohort study on health effects of asbestos exposure in Japan. Cancer Science. 2019; 110 (3):1076-1084.

Chicago/Turabian Style

Ling Zha; Yuri Kitamura; Tetsuhisa Kitamura; Rong Liu; Masayuki Shima; Norio Kurumatani; Tomoki Nakaya; Junko Goji; Tomotaka Sobue. 2019. "Population‐based cohort study on health effects of asbestos exposure in Japan." Cancer Science 110, no. 3: 1076-1084.

Journal article
Published: 10 October 2018 in Environmental Health and Preventive Medicine
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As society is aging, the number of elderly patients with psychiatric disorder, such as dementia, is increasing. The hospitalization period of elderly patients in psychiatric wards tends to be prolonged. In this study, we have determined the factors that inhibit early discharge from the psychiatric emergency ward for elderly patients in Japan. The information was collected from patients admitted to our hospital's emergency ward for elderly patients with psychiatric disorders between May 2015 and April 2016. We compared various factors between the early discharge group and the non-early discharge group. In addition, we used a multiple logistic regression model to clarify the risk factors for non-early discharge. Of the 208 elderly patients, body mass index (BMI) and serum albumin level were significantly lower in the non-early discharge group. In addition, we also showed that higher serum C-reactive protein (CRP) (> 0.5 mg/dL) and use of seclusion or physical restraint significantly inhibited the early discharge of patients. The results of multiple logistic analysis showed that the BMI ≤ 17.5 kg/m2 (OR, 2.41 [95% confidence interval (CI) 1.06-5.46]), serum albumin level ≤ 30 g/L (OR, 3.78 [95% CI 1.28-11.16]), and use of seclusion or physical restraint (OR 3.78 [95% CI 1.53-9.37]) are particularly important explanatory factors. Hypoalbuminemia, low BMI, and the use of seclusion or physical restraint were identified as the factors that inhibit early discharge from the psychiatric emergency ward for elderly patients. These factors reflect malnutrition and extremely serious psychiatric symptoms.

ACS Style

Sho Adachi; Tomoko Komiya; Kenji Nomura; Masayuki Shima. Factors for inhibition of early discharge from the psychiatric emergency ward for elderly patients. Environmental Health and Preventive Medicine 2018, 23, 48 .

AMA Style

Sho Adachi, Tomoko Komiya, Kenji Nomura, Masayuki Shima. Factors for inhibition of early discharge from the psychiatric emergency ward for elderly patients. Environmental Health and Preventive Medicine. 2018; 23 (1):48.

Chicago/Turabian Style

Sho Adachi; Tomoko Komiya; Kenji Nomura; Masayuki Shima. 2018. "Factors for inhibition of early discharge from the psychiatric emergency ward for elderly patients." Environmental Health and Preventive Medicine 23, no. 1: 48.

Journal article
Published: 01 September 2018 in Science of The Total Environment
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Adequate spatial and temporal estimates of NO2 concentrations are essential for proper prenatal exposure assessment. Here, we develop a spatiotemporal land use random forest (LURF) model of the monthly mean NO2 over four years in a metropolitan area of Japan. The overall objective is to obtain accurate NO2 estimates for use in prenatal exposure assessments. We use random forests to convey the non-linear relationship between NO2 concentrations and predictor variables, and compare the prediction accuracy with that of a linear regression. In addition, we include the distance decay effect of emission sources on NO2 concentrations for more efficient model construction. The prediction accuracy of the LURF model is evaluated through a leave-one-monitor-out cross validation. We obtain a high R2 value of 0.79, which is better than that of the conventional land use regression model using linear regression (R2 of 0.73). We also evaluate the LURF model via a temporal and overall cross validation and obtain R2 values of 0.84 and 0.92, respectively. We successfully integrate temporal and spatial components into our model, which exhibits higher accuracy than spatial models constructed individually for each month. Our findings illustrate the advantage of using a LURF to model the spatiotemporal variability of NO2 concentrations.

ACS Style

Shin Araki; Masayuki Shima; Kouhei Yamamoto. Spatiotemporal land use random forest model for estimating metropolitan NO2 exposure in Japan. Science of The Total Environment 2018, 634, 1269 -1277.

AMA Style

Shin Araki, Masayuki Shima, Kouhei Yamamoto. Spatiotemporal land use random forest model for estimating metropolitan NO2 exposure in Japan. Science of The Total Environment. 2018; 634 ():1269-1277.

Chicago/Turabian Style

Shin Araki; Masayuki Shima; Kouhei Yamamoto. 2018. "Spatiotemporal land use random forest model for estimating metropolitan NO2 exposure in Japan." Science of The Total Environment 634, no. : 1269-1277.

Journal article
Published: 28 August 2018 in Environmental Health and Preventive Medicine
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The health effects of biological aerosols on the respiratory system are unclear. The purpose of this study was to clarify the association of airborne particle, protein, and endotoxin with emergency department visits for asthma in Kyoto City, Japan. We collected data on emergency department visits at a hospital in Kyoto from September 2014 to May 2016. Fine (aerodynamic diameter ≤ 2.5 μm) and coarse (≥ 2.5 μm) particles were collected in Kyoto, and protein and endotoxin levels were analyzed. The association of the levels of particles, protein, endotoxin, and meteorological factors (temperature, relative humidity, wind speed, and air pressure) with emergency department visits for asthma was estimated. There were 1 to 15 emergency department visits for asthma per week, and the numbers of visits increased in the autumn and spring, namely many weeks in September, October, and April. Weekly concentration of protein in fine particles was markedly higher than that in coarse particles, and protein concentration in fine particles was high in spring months. Weekly endotoxin concentrations in fine and coarse particles were high in autumn months, including September 2014 and 2015. Even after adjusting for meteorological factors, the concentrations of coarse particles and endotoxin in both particles were significant factors on emergency department visits for asthma. Our results suggest that atmospheric coarse particles and endotoxin are significantly associated with an increased risk of asthma exacerbation.

ACS Style

Mohammad Shahriar Khan; Souleymane Coulibaly; Takahiro Matsumoto; Yoshitaka Yano; Makoto Miura; Yukio Nagasaka; Masayuki Shima; Nobuyuki Yamagishi; Keiji Wakabayashi; Tetsushi Watanabe. Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan. Environmental Health and Preventive Medicine 2018, 23, 41 .

AMA Style

Mohammad Shahriar Khan, Souleymane Coulibaly, Takahiro Matsumoto, Yoshitaka Yano, Makoto Miura, Yukio Nagasaka, Masayuki Shima, Nobuyuki Yamagishi, Keiji Wakabayashi, Tetsushi Watanabe. Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan. Environmental Health and Preventive Medicine. 2018; 23 (1):41.

Chicago/Turabian Style

Mohammad Shahriar Khan; Souleymane Coulibaly; Takahiro Matsumoto; Yoshitaka Yano; Makoto Miura; Yukio Nagasaka; Masayuki Shima; Nobuyuki Yamagishi; Keiji Wakabayashi; Tetsushi Watanabe. 2018. "Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan." Environmental Health and Preventive Medicine 23, no. 1: 41.