After obtaining his PhD in Biochemistry from Queens University in Canada, Mathieu did his Postdoctoral Fellowship at the Child & Family Research Institute in Vancouver, where he focused on delineating the immune responses to common pathogenic ligands in infants and the mechanisms of neonatal immune protection via maternal vaccination. His research endeavors aim to improve prevention and treatments for infectious diseases in neonates. Mathieu then expanded his research horizon working as a Scientist for the Medical Research Council in The Gambia, where he investigated the role of natural killer cells in the pathogenesis of tuberculosis and developed his interest in immune biomarkers. At Sidra, Mathieu is investigating the collective data-to-knowledge approach to metadata mining for discovery of novel markers of sepsis and improvement of the management of sepsis. This work parallels his research plan to develop of a blood transcriptomic signature predictive of postoperative sepsis in pediatric patients.