Hypertension is a widespread chronic disease. Risk prediction of hypertension is an intervention that contributes to the early prevention and management of hypertension. The implementation of such intervention requires an effective and easy-to-implement hypertension risk prediction model. This study evaluated and compared the performance of four machine learning algorithms on predicting the risk of hypertension based on easy-to-collect risk factors. A dataset of 29,700 samples collected through a physical examination was used for model training and testing. Firstly, we identified easy-to-collect risk factors of hypertension, through univariate logistic regression analysis. Then, based on the selected features, 10-fold cross-validation was utilized to optimize four models, random forest (RF), CatBoost, MLP neural network and logistic regression (LR), to find the best hyper-parameters on the training set. Finally, the performance of models was evaluated by AUC, accuracy, sensitivity and specificity on the test set. The experimental results showed that the RF model outperformed the other three models, and achieved an AUC of 0.92, an accuracy of 0.82, a sensitivity of 0.83 and a specificity of 0.81. In addition, Body Mass Index (BMI), age, family history and waist circumference (WC) are the four primary risk factors of hypertension. These findings reveal that it is feasible to use machine learning algorithms, especially RF, to predict hypertension risk without clinical or genetic data. The technique can provide a non-invasive and economical way for the prevention and management of hypertension in a large population.

Named Entity Recognition (NER) is the fundamental task for Natural Language Processing (NLP) and the initial step in building a Knowledge Graph (KG). Recently, BERT (Bidirectional Encoder Representations from Transformers), which is a pre-training model, has achieved state-of-the-art (SOTA) results in various NLP tasks, including the NER. However, Chinese NER is still a more challenging task for BERT because there are no physical separations between Chinese words, and BERT can only obtain the representations of Chinese characters. Nevertheless, the Chinese NER cannot be well handled with character-level representations, because the meaning of a Chinese word is quite different from that of the characters, which make up the word. ERNIE (Enhanced Representation through kNowledge IntEgration), which is an improved pre-training model of BERT, is more suitable for Chinese NER because it is designed to learn language representations enhanced by the knowledge masking strategy. However, the potential of ERNIE has not been fully explored. ERNIE only utilizes the token-level features and ignores the sentence-level feature when performing the NER task. In this paper, we propose the ERNIE-Joint, which is a joint model based on ERNIE. The ERNIE-Joint can utilize both the sentence-level and token-level features by joint training the NER and text classification tasks. In order to use the raw NER datasets for joint training and avoid additional annotations, we perform the text classification task according to the number of entities in the sentences. The experiments are conducted on two datasets: MSRA-NER and Weibo. These datasets contain Chinese news data and Chinese social media data, respectively. The results demonstrate that the ERNIE-Joint not only outperforms BERT and ERNIE but also achieves the SOTA results on both datasets.

The medical literature contains valuable knowledge, such as the clinical symptoms, diagnosis, and treatments of a particular disease. Named Entity Recognition (NER) is the initial step in extracting this knowledge from unstructured text and presenting it as a Knowledge Graph (KG). However, the previous approaches of NER have often suffered from small-scale human-labelled training data. Furthermore, extracting knowledge from Chinese medical literature is a more complex task because there is no segmentation between Chinese characters. Recently, the pretraining models, which obtain representations with the prior semantic knowledge on large-scale unlabelled corpora, have achieved state-of-the-art results for a wide variety of Natural Language Processing (NLP) tasks. However, the capabilities of pretraining models have not been fully exploited, and applications of other pretraining models except BERT in specific domains, such as NER in Chinese medical literature, are also of interest. In this paper, we enhance the performance of NER in Chinese medical literature using pretraining models. First, we propose a method of data augmentation by replacing the words in the training set with synonyms through the Mask Language Model (MLM), which is a pretraining task. Then, we consider NER as the downstream task of the pretraining model and transfer the prior semantic knowledge obtained during pretraining to it. Finally, we conduct experiments to compare the performances of six pretraining models (BERT, BERT-WWM, BERT-WWM-EXT, ERNIE, ERNIE-tiny, and RoBERTa) in recognizing named entities from Chinese medical literature. The effects of feature extraction and fine-tuning, as well as different downstream model structures, are also explored. Experimental results demonstrate that the method of data augmentation we proposed can obtain meaningful improvements in the performance of recognition. Besides, RoBERTa-CRF achieves the highest F1-score compared with the previous methods and other pretraining models.

Using absolute intensity methods (metabolic equivalent of energy (METs), etc.) to determine exercise intensity in exercise prescriptions is straightforward and convenient. Using relative intensity methods (heart rate reserve (%HRR), maximal heart rate (%HR_max), etc.) is more recommended because it is more personalized. Taking target heart rate (THR) given by the relative method as an example, compared with just presenting the THR value, intuitively providing the setting parameters for achieving the THR with specific sport equipment is more user-friendly. The objective of this study was to find a method which combines the advantages (convenient and personalized) of the absolute and relative methods and relatively avoids their disadvantages, helping individuals to meet the target intensity by simply setting equipment parameters. For this purpose, we recruited 32 males and 29 females to undergo incremental cardiopulmonary exercise testing with cycling equipment. The linear regression model of heart rate and exercise wattage (the setting parameter of the equipment) was constructed for each one (R² = 0.933, p < 0.001), and the slopes of the graph of these models were obtained. Next, we used an iterative algorithm to obtain a multiple regression model (adjusted R² = 0.8336, p < 0.001) of selected static body data and the slopes of participants. The regression model can accurately predict the slope of the general population through their static body data. Moreover, other populations can guarantee comparable accuracy by using questionnaire data for calibration. Then, the predicted slope can be utilized to calculate the equipment’s settings for achieving a personalized THR through our equation. All of these steps can be assigned to the intelligent system.

Background: There is the highest estimated number of patients with obstructive sleep apnea (OSA) in China. Early treatment could lead to fewer complications associated with OSA. This study aimed to analyze the factors influencing help-seeking from the first symptom discovery to treatment in OSA. Methods: Semi-structured interview outline was designed to conduct face-to-face interview based on the analyses of a great number of related literatures on the delay in seeking medical attention of patients with OSA. 15 patients diagnosed were interviewed between June 2021 to September 2022 in general hospital of Shenyang, Northeastern of China. Qualitative data was analyzed by content analysis using the Model of Pathways to Treatment. Results: Analyses identified factors contributing to elapsed time from first symptom discovery to received treatment that are linked to disease characteristic, patients, health system organization. Appraisal interval is most obvious for patients with OSA, but it is difficult to pinpoint precisely because the patients didn’t remember exactly when the first symptom was detected. Conclusions: Patients diagnosed with OSA didn’t initially interpret the snore as a warning sign and even thought it was a blessing. The findings provided guidance or avenues for reducing elapsed time between the first symptom and received treatment.