Chuen-Chau Chang

Chuen-Chau Chang

orcid

Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 October 2017 in BioMed Research International
Verified
Journal Article
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HTHsiao-Chien Tsai
Hsiao-Chien Tsai
TYTakayuki Yoshida
Takayuki Yoshida
TCTai-Yuan Chuang
Tai-Yuan Chuang
SYSheng-Feng Yang
Sheng-Feng Yang
CCChuen-Chau Chang
Chuen-Chau Chang
KCKung-Yen Chen
Kung-Yen Chen
Purpose of Review. Transversus abdominis plane (TAP) block is a regional technique for analgesia of the anterolateral abdominal wall. This review highlights the nomenclature system and recent advances in TAP block techniques and proposes directions for future research.Recent Findings. Ultrasound guidance is now considered the gold standard in TAP blocks. It is easy to acquire ultrasound images; it can be used in many surgeries involving the anterolateral abdominal wall. However, the efficacy of ultrasound-guided TAP blocks is not consistent, which might be due to the use of different approaches. The choice of technique influences the involved area and block duration. To investigate the actual analgesic effects of TAP blocks, we unified the nomenclature system and clarified the definition of each technique. Although a single-shot TAP block is limited in duration, it is still the candidate of the analgesic standard for abdominal wall surgery because the use of the catheter technique and liposomal bupivacaine may overcome this limitation.Summary. Ultrasound-guided TAP blocks are commonly used. With the unified nomenclature and the development of catheter technique and/or liposomal local anesthetics, TAP blocks can be applied more appropriately to achieve better pain control.

16 January 2019 in Journal of Clinical Medicine
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Journal Article
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CLChao-Shun Lin
Chao-Shun Lin
CCChuen-Chau Chang
Chuen-Chau Chang
YLYuan-Wen Lee
Yuan-Wen Lee
CLChih-Chung Liu
Chih-Chung Liu
CYChun-Chieh Yeh
Chun-Chieh Yeh
CLChien-Chang Liao
Chien-Chang Liao
The impact of diabetes on perioperative outcomes remains incompletely understood. Our purpose is to evaluate post-operative complications and mortality in patients with diabetes. Using the institutional and clinical databases of three university hospitals from 2009–2015, we conducted a matched study of 16,539 diabetes patients, aged >20 years, who underwent major surgery. Using a propensity score matching procedure, 16,539 surgical patients without diabetes who underwent surgery were also selected. Logistic regressions were used to calculate the odds ratios (ORs) with 95% confidence intervals (CIs) for post-operative complications and in-hospital mortality associated with diabetes. Patients with diabetes had a higher risk of postoperative septicemia (OR 1.33, 95% CI 1.01–1.74), necrotizing fasciitis (OR 3.98, 95% CI 1.12–14.2), cellulitis (OR 2.10, 95% CI 1.46–3.03), acute pyelonephritis (OR 1.86, 95% CI 1.01–3.41), infectious arthritis (OR 3.89, 95% CI 1.19–12.7), and in-hospital mortality (OR 1.51, 95% CI 1.07–2.13) compared to people without diabetes. Previous admission for diabetes (OR 2.33, 95% CI 1.85–2.93), HbA1c >8% (OR 1.96, 95% CI 1.64–2.33) and fasting glucose >180 mg/dL (OR 1.90, 95% CI 1.68–2.16) were predictors for post-operative adverse events. Diabetes patients who underwent surgery had higher risks of infectious complications and in-hospital mortality compared with patients without diabetes who underwent similar major surgeries.

1 May 2019 in Clinical Epidemiology
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Journal Article
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KLKa Man Lai
Ka Man Lai
TCTa-Liang Chen
Ta-Liang Chen
CCChuen-Chau Chang
Chuen-Chau Chang
HCHsi-Hsien Chen
Hsi-Hsien Chen
YLYuan-Wen Lee
Yuan-Wen Lee
Background: Pain is one of the most common symptoms experienced by patients with end-stage renal disease. Although NSAIDs may lead to adverse events, NSAID use appears to be considerably high in patients with end-stage renal disease. However, whether NSAID use is associated with an increased risk of mortality in this population remains unknown. Aim: This study aimed to investigate the association between the use of NSAIDs and the risk of mortality in patients with end-stage renal disease. Patients and methods: We used the population-based Taiwan National Health Insurance Research Database to investigate the association between the use of NSAIDs and the risk of mortality in patients with end-stage renal disease receiving dialysis. A total of 3,383 patients with newly diagnosed end-stage renal disease requiring long-term dialysis between 1998 and 2012 were included in the current study, and the study outcome was evaluated until December 31, 2013. Time-dependent Cox regression models were applied to examine the association between NSAID use and mortality risk. Results: In the study cohort, 2,623 (78%) patients used NSAIDs during the follow-up period. The median follow-up period was 4.0 years, during which 1,515 patients died. The results of multivariable analysis demonstrated that compared with NSAID nonuse, the use of any NSAIDs, nonselective NSAIDs, and selective cyclooxygenase-2 inhibitors was associated with a significantly increased risk of all-cause mortality with an adjusted HR (95% CI) of 1.39 (1.21–1.60), 1.36 (1.19–1.55), and 1.61 (1.42–1.83), respectively. Conclusion: The results suggest that NSAID use was associated with an increased risk of mortality in the patients with end-stage renal disease. Future randomized controlled trials are needed to validate these observational findings.

1 December 2017 in Asian Journal of Anesthesiology
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Journal Article
Open access
KLK.M. Lai
K.M. Lai
MHM.H. Hsieh
M.H. Hsieh
FLF. Lam
F. Lam
CCChien-yu Chen
Chien-yu Chen
TCT.L. Chen
T.L. Chen
CCChuen-Chau Chang
Chuen-Chau Chang
Tracheal bronchus is a congenital anatomical variant of patients with accessory bronchus in the right upper lobe deriving directly from the supracarinal trachea. Pre-operative consultation with the anesthesiologist is important for patient safety and can avoid adverse effects induced by endotracheal intubation. In this report, we described a case of tracheal bronchus in which general anesthesia was performed for video-assisted thoracoscopic surgery. We discussed some of the issues surrounding to complications in tracheal bronchus.

1 November 2020 in Clinical Epidemiology
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Journal Article
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YTYing-Hsuan Tai
Ying-Hsuan Tai
CCChuen-Chau Chang
Chuen-Chau Chang
CYChun-Chieh Yeh
Chun-Chieh Yeh
LSLi-Chin Sung
Li-Chin Sung
CHChaur-Jong Hu
Chaur-Jong Hu
CLChien-Chang Liao
Chien-Chang Liao
Objective: To evaluate the long-term risk of stroke and poststroke adverse outcomes in patients with heart failure (HF). Methods: We used research data from Taiwan’s National Health Insurance Program from 2000 to 2005 and identified 20,072 adults aged ≥ 30 years who were newly diagnosed with HF. Frequency matching based on age and sex was used to select a comparison cohort consisting of 80,288 adults without HF. Events of incident stroke were identified from medical claims during the 2000– 2013 follow-up period. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of the association of stroke with HF were calculated with a multiple Cox proportional hazard model. Another nested stroke cohort study of 480,604 hospitalized stroke patients determined the adjusted odds ratios (ORs) and 95% CIs for adverse events after stroke in patients with and without HF between 2000 and 2009. Results: Compared with the non-HF cohort, HF patients had an increased risk of stroke (HR 2.32, 95% CI 2.21– 2.43), including ischemic stroke and hemorrhagic stroke. The association between HF and stroke was significant in both sexes and in patients in all age groups and with various medical conditions. Previous HF was associated with poststroke mortality (OR 1.40, 95% CI 1.31– 1.50), pneumonia (OR 1.33, 95% CI 1.28– 1.38), and septicemia (OR 1.30, 95% CI 1.23– 1.37). Conclusion: HF was associated with a higher risk of stroke, and patients with HF had more complications and greater mortality after stroke.

28 March 2023 in International Journal of Surgery
Verified
Journal Article
Open access
YLYu-Chen Liao
Yu-Chen Liao
CCChuen-Chau Chang
Chuen-Chau Chang
CCChien-yu Chen
Chien-yu Chen
CLChih-Chung Liu
Chih-Chung Liu
CLChien-Chang Liao
Chien-Chang Liao
CLChao-Shun Lin
Chao-Shun Lin
Background: The incidence of chronic kidney disease is increasing, but most cases are not diagnosed until the accidental finding of abnormal laboratory data or the presentation of severe symptoms. Patients with chronic kidney disease are reported to have an increased risk of postoperative mortality and morbidities, but previous studies mainly targeted populations undergoing cardiovascular surgery. The authors aimed to evaluate the risk of postoperative mortality and complications in a surgical population with preoperative renal insufficiency (RI). Materials and Methods: This retrospective cohort study used data from the National Surgical Quality Improvement Program database between 2013 and 2018 to evaluate the risk of postoperative morbidity and mortality in the surgical population. Patients with estimated glomerular filtration rate less than 60 ml/min/1.73 m2 were defined as the RI group. Propensity score matching methods and multivariate logistic regression were used to calculate the risk of postoperative morbidity and mortality. Results: After propensity score matching, 502 281 patients were included in the RI and non-RI groups. The RI group had a higher risk of 30-day in-hospital mortality (odds ratio: 1.54, 95% CI: 1.49–1.58) than the non-RI group. The RI group was associated with a higher risk of postoperative complications, including myocardial infarction, stroke, pneumonia, septic shock, and postoperative bleeding. The RI group was also associated with an increased risk of prolonged ventilator use for over 48 h, readmission, and reoperation. Conclusion: Patients with preoperative RI have an increased risk of postoperative 30-day mortality and complications. RI group patients with current dialysis, estimated glomerular filtration rate less than or equal to 30 ml/min/1.73 m2 or concomitant anemia had an elevated risk of postoperative mortality.