As a novel concept of responding to disease epidemics, Fangcang shelter hospitals were deployed to expand the health system’s capacity and provide medical services for non-severe COVID-19 patients during the outbreak in Wuhan. To give insights on patient management within Fangcang hospitals, we conducted a retrospective analysis to: 1) describe the characteristics of the patients admitted to Fangcang hospitals and 2) explore risk factors for longer length of stay (LOS). We enrolled 136 confirmed COVID-19 patients, including asymptomatic patients and those with mild symptoms, who were hospitalized in the Wuti Fangcang Hospital. 58 patients completed the treatment and discharged before 1 March 2020. After describing patients’ demographic and clinical characteristics, exposure history, treatment received and time course of the disease, we conducted linear regression analysis to identify factors influencing LOS. We found that patients having fever before admission were hospitalized 3.5 days (95%CI 1.39 to 5.63, p = 0.002) longer than those without fever and that patients having bilateral pneumonia were hospitalized 3.4 days (95%CI 0.49 to 6.25, p = 0.023) longer than those with normal CT scan results. We also found weak evidence suggesting that patients with diabetes were hospitalized 3.2 days longer than those without diabetes (95%CI -0.2 to 6.56, p = 0.065). However, we observed no significant differences in LOS between symptomatic and asymptomatic patients and between patients who received treatment and those without treatment. Longer duration of hospitalization among non-severe COVID-19 patients is associated with having fever, bilateral pneumonia on CT scan and diabetes. However, being asymptomatic and using supportive medications at the early stage of infection do not have significant influences on LOS. Our study is a single-centered study with relatively small sample size. The findings provide evidence for predicting hospital bed demand in a novel response scenario and may help decision-makers in preparing for ramping up the health system capacity.

Herein, we evaluated the efficacy and safety of intra-arterial mild hypothermia in combination with arterial thrombolysis to treat acute cerebral infarction due to middle cerebral artery occlusion. A total of 26 patients with acute middle cerebral artery occlusion were divided into a normothermia group (n = 15) and a mild hypothermia group (n = 11). The infarct volumes at 24 h and 7 days after the operation were compared between the normothermia group and the mild hypothermia group. Additionally, we compared neurological deficit scores between the two groups at 24 h, 7 days, and 1 mo after the operation. The infarct volumes and neurological deficit scores of the mild hypothermia group were significantly reduced compared to those in the normothermia group (p < 0.05). Furthermore, no adverse reactions or complications occurred in the mild hypothermia group. Intra-arterial mild hypothermia reduced infarct volume after ischemia–reperfusion injury in the arterial thrombolysis of an acute cerebral infarction. Additionally, it improved the prognosis of patients with an acute middle cerebral artery occlusion, suggesting that this procedure is safe and effective for treating acute cerebral infarction.

Background: Hypertension remains a major public health challenge in rural China, where sustained blood pressure (BP) control is often suboptimal. Although antihypertensive medication use is central to hypertension management, real-world evidence integrating treatment strategies, medication adherence, and longitudinal BP control in rural primary care settings remains limited. Time in target range (TTR) has emerged as an indicator of sustained blood pressure (BP) control, particularly relevant in community-based settings with infrequent follow-up, yet its application in routine rural primary care management remains insufficiently characterized. Methods: This real-world retrospective cohort study included 5,029 adults (≥35 years) with diagnosed hypertension who completed four consecutive quarterly follow-up visits in 2024 under China’s National Basic Public Health Service Program in rural Hubei Province. BP control (<140/90 mmHg) was assessed at each visit, and annual TTR was calculated as the proportion of visits meeting the BP target (satisfactory control: TTR ≥ 75%). Medication use (none, monotherapy, combination therapy) and medication adherence (adherent, partially adherent, non-adherent) were integrated into a composite treatment–adherence exposure. Generalized estimating equation models were used to examine longitudinal associations between treatment–adherence patterns and BP control, adjusting for demographic factors, comorbidities, lifestyle variables, and time effects. Results: Among all participants, 22.1% were not taking antihypertensive medication, 58.5% were on monotherapy, and 19.4% were on combination therapy. Overall BP control rates increased modestly over four quarterly visits. Compared with no medication use, medication use with good adherence was associated with a higher likelihood of BP control [odds ratio (OR) = 1.547, 95% confidence interval (CI): 1.388–1.725], whereas medication use with poor adherence was associated with a lower likelihood of control (OR = 0.847, 95% CI: 0.735–0.975)—suggesting it may be less effective than no treatment, possibly due to irregular intake or unmeasured confounding factors. Longitudinal trends showed stable improvement in BP control among patients with good adherence, while control declined among those not receiving medication. Sex-specific analyses indicated that poor adherence was more adversely associated with BP control among men than women. Conclusion: In this rural primary care population, sustained antihypertensive medication adherence was consistently associated with better longitudinal BP control, whereas irregular or absent treatment was linked to unstable or declining control. These findings suggest that expanding medication coverage alone may be insufficient for improving hypertension outcomes in rural settings. Routine adherence assessment and targeted strategies for high-risk subgroups, particularly men and patients with diabetes, may help inform community-based hypertension management programs.