Alzheimer’s disease (AD) is a progressive neurodegenerative disease. In this study, to investigate the effect of microglial elimination on AD progression, we administered PLX3397, a selective colony-stimulating factor 1 receptor inhibitor, to the mouse model of AD (5xFAD mice). Amyloid-beta (Aβ) deposition and amyloid precursor protein (APP), carboxyl-terminal fragment β, ionized calcium-binding adaptor molecule 1, synaptophysin, and postsynaptic density (PSD)-95 levels were evaluated in the cortex and hippocampus. In addition, the receptor density changes in dopamine D2 receptor (D2R) and metabotropic glutamate receptor 5 were evaluated using positron emission tomography (PET). D2R, tyrosine hydroxylase (TH), and dopamine transporter (DAT) levels were analyzed in the brains of Tg (5xFAD) mice using immunohistochemistry. PLX3397 administration significantly decreased Aβ deposition following microglial depletion in the cortex and hippocampus of Tg mice. In the neuro-PET studies, the binding values for D2R in the Tg mice were lower than those in the wild type mice; however, after PLX3397 treatment, the binding dramatically increased. PLX3397 administration also reversed the changes in synaptophysin and PSD-95 expression in the brain. Furthermore, the D2R and TH expression in the brains of Tg mice was significantly lower than that in the wild type; however, after PLX3397 administration, the D2R and TH levels were significantly higher than those in untreated Tg mice. Thus, our findings show that administering PLX3397 to aged 5xFAD mice could prevent amyloid pathology, concomitant with the rescue of dopaminergic signaling, suggesting that targeting microglia may serve as a useful therapeutic option for neurodegenerative diseases, including AD.

This paper reports the electromagnetic field (EMF) exposure levels from fifth generation (5G) services. Three mobile operators in South Korea launched the world's first 5G New Radio networks using the 3.5 GHz band in April 2019. The transmitted power of the uplink slots and the synchronization signal reference signal received power (SS-RSRP) from user equipment (UE) were measured in Seoul. The power samples, averaged over a 1-s duration, were obtained for a traffic period of approximately 270 h from October 2019 to early February 2020 using the file transfer protocol while driving along the side streets in residential areas of Seoul. The measurement results show that the time-average level when exposed to a beam sweep of the base stations was less than 5 μW/m ² . However, the UE transmitted power level approached the maximum for a considerable period of the total measurement time owing to the extremely low SS-RSRP level of the base stations.

The dimensions of the human body vary by age, sex, and race. The internal structure and outer dimensions of a body exposed to an electromagnetic field is important for accurate dosimetry. The average physical size of Korean adult males between the ages 18 to 24 was investigated, and a male volunteer was selected whose physical condition is within the physical standards, ° 5%. Magnetic resonance images and partially computerized tomography images of the volunteer were acquired. The intervals between the transverse images were 1 mm for the head and 3 mm for the rest of the body. About 30 different tissues were manually classified by an anatomist on the raw images, and the segmented images were implemented in the form of a text file appropriate for numerical formulation.

The expansion of mobile phone use has raised questions regarding the possible biological effects of radiofrequency electromagnetic field (RF-EMF) exposure on oxidative stress and brain inflammation. Despite accumulative exposure of humans to radiofrequency electromagnetic fields (RF-EMFs) from mobile phones, their long-term effects on oxidative stress and neuroinflammation in the aging brain have not been studied. In the present study, middle-aged C57BL/6 mice (aged 14 months) were exposed to 1950 MHz electromagnetic fields for 8 months (specific absorption rate (SAR) 5 W/kg, 2 h/day, 5 d/week). Compared with those in the young group, levels of protein (3-nitro-tyrosine) and lipid (4-hydroxy-2-nonenal) oxidative damage markers were significantly increased in the brains of aged mice. In addition, levels of markers for DNA damage (8-hydroxy-2′-deoxyguanosine, p53, p21, γH2AX, and Bax), apoptosis (cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase 1 (PARP-1)), astrocyte (GFAP), and microglia (Iba-1) were significantly elevated in the brains of aged mice. However, long-term RF-EMF exposure did not change the levels of oxidative stress, DNA damage, apoptosis, astrocyte, or microglia markers in the aged mouse brains. Moreover, long-term RF-EMF exposure did not alter locomotor activity in aged mice. Therefore, these findings indicate that long-term exposure to RF-EMF did not influence age-induced oxidative stress or neuroinflammation in C57BL/6 mice.

For the wireless power transfer (WPT) system in implantable medical devices (IMDs), human tissue is positioned between the transmitting and receiving coils which are different from general WPT systems. Because this space is where the strongest electromagnetic field (EMF) occurs, it is essential to reduce the EMF at the interspace to reduce human exposure to the EMF. In this paper, an out-of-phase coupled WPT system for IMDs is proposed to reduce human exposure to EMF. Considering the EMF exposure and power transfer efficiency (PTE) of the proposed system, a design procedure for determining the phase difference of each capacitor is analyzed and presented. Based on the equivalent circuit model analysis of the proposed system, the EMF and PTE characteristics of the WPT system depending on the design variables are comprehensively analyzed. The proposed system is compared with conventional systems through simulation and measurements. It is verified that the proposed system can reduce the EMF by 41.05% and increase the PTE by 9.62% compared to the conventional system. In addition, through simulation, human exposure to EMFs is assessed considering the exposure environment and electrical properties of human tissues. As a result, the current density, induced electric field, and specific absorption rate were reduced by 44.10%, 38.90%, and 63.82%, respectively.

Using scaled models for an anatomical head model and a simple head model, we investigated the effects of head size on specific absorption rate characteristics for two mobile phones operating at 835 MHz and 1765 MHz. Our results showed that a larger head produced a higher localized SAR at 835 MHz. However, at 1765 MHz, the differences among the head models were insignificant since the superficial absorption was dominant over the effects of head shape and size. A larger head produced a lower whole-head averaged SAR at both frequencies.