The mechanical properties of fractured rock mass have an important influence on the safety and stability of underground engineering. Grouting is a common way to reinforce fractured rock mass. The uniaxial compression tests of red sandstone specimens with different prefabricated crack inclination angles before and after grouting were carried out. Based on the load-deformation data and synchronous image acquisition, the mechanical properties, crack propagation law and failure mode of the specimens before and after grouting were studied. The results show that the peak strength and elastic modulus of the ungrouted specimen increase with the increase of the inclination angle of the prefabricated crack. Compared with the ungrouted specimen, grouting can significantly improve the peak strength and elastic modulus of the specimen. The cracks of the ungrouted specimen mainly initiate from the tip of the prefabricated crack, and the cracks of the grouting specimen mainly initiate from the upper and lower surfaces of the specimen and the far field. Based on the macroscopic and microscopic damage theory, the constitutive model of grouting rock mass is proposed. By comparing with the experimental data, the rationality of the constitutive model is verified.