Despite the identification of Aβ plaques and NFTs as biomarkers for Alzheimer’s disease (AD) pathology, therapeutic interventions remain elusive, with neither an absolute prophylactic nor a curative medication available to impede the progression of AD presently available. Current approaches focus on symptomatic treatments to maintain AD patients’ mental stability and behavioral symptoms by decreasing neuronal degeneration; however, the complexity of AD pathology requires a wide range of therapeutic approaches for both preventive and curative treatments. In this regard, this review summarizes the role of receptors as a potential target for treating AD and focuses on the path of major receptors which are responsible for AD progression. This review gives an overall idea centering on major receptors, their agonist and antagonist and future prospects of viral mimicry in AD pathology. This article aims to provide researchers and developers a comprehensive idea about the different receptors involved in AD pathogenesis that may lead to finding a new therapeutic strategy to treat AD.

Diabetes is a contributor to morbidity across the globe and is often associated with obesity, metabolic syndrome and other inflammatory diseases associated with aging. In addition to genetic and lifestyle factors, environmental factors such as metals and persistent organic pollutants may increase the severity or lower the threshold of these conditions. In cell culture, methylmercury is toxic to adipocytes and may impact adipokine secretions. In this study, we determined the effects of different concentrations of theaflavin digallate on methylmercury exposed 3T3-L1 adipocytes in cell culture. Secretions of resistin, adiponectin and lipid peroxidation product, 4-hydroxynonenal (4-HNE) were monitored using ELISA assays. Cell morphology of methylmercury and theaflavin-3,3′-digallate treated adipocytes was assessed using Lipid (Oil Red O) staining. Exposure to methylmercury increased the levels of resistin and adiponectin as well as 4-HNE when compared to the control cells. Methylmercury treated cells resulted in smaller number of adipocytes and clumped lipid droplets. These results suggest that methylmercury induces reactive oxygen species leading to development of an inflammatory response. Theaflavin-3,3′-digallate reduced the impact of methylmercury by maintaining the adipocytes morphology and secretion patterns of adiponectin, resistin and 4-hydroxynonenal. With this experimental model system other anti-inflammatory and signaling agents could be tested at the biochemical level before eventually leading to studies in animal models.

Using sled dogs as exercise model, our objectives of this study were to (1) assess the effects of one acute bout of high-intensity exercise on surface GLUT4 concentrations on easily accessible peripheral blood mononuclear cells (PBMC) and (2) compare our findings with published research on exercise induced GLUT4 in skeletal muscle. During the exercise bout, dogs ran 5 miles at approximately 90% of VO2 max. PMBC were collected before exercise (baseline), immediately after exercise and after 24 h recovery.GLUT4 was measured via ELISA. Acute exercise resulted in a significant increase on surface GLUT4 content on PBMC. GLUT4 was increased significantly immediately after exercise (~50%; p0.05). An effect of acute exercise on GLUT4 levels translocated to the cell membrane was observed, with GLUT4 levels not yet returned to baseline after 24 h post-exercise. In conclusion, the present investigation demonstrated that acute high-intensity exercise increased GLUT4 content at the surface of PBMC of sled dogs as it has been reported in skeletal muscle in other species. Our findings underline the potential use of peripheral blood mononuclear cell GLUT4 protein content as minimally invasive proxy to investigate relationships between insulin sensitivity, insulin resistance, GLUT4 expression and glucose metabolism.

Reindeer and caribou are terrestrial herbivores, that feed on lichens and are used for commercial and subsistence food products. Caribou are a key component of the arctic food web and the bioaccumulation of toxic contaminants, such as mercury (Hg), needs to be monitored to establish a baseline as the arctic environment is impacted by both climate change and future industrial development. A changing climate in Alaska is influencing plant species composition, fire regime, melting and flooding events, and thus, impacting Hg bioavailability in the food chain. Industrial development in Asia is also projected to increase the atmospheric global pool of Hg from increased coal combustion. Reindeer, a domesticated representative of caribou, can be used as a terrestrial biomonitor for metal exposure. In this study total mercury concentrations were measured in lichens and in hair of grazing reindeer on defined ranges across Alaska to establish a baseline for future hypothesis development and testing regarding Hg deposition. The Hg mean level for Seward Peninsula lichens on the Davis Range was 37.4 ng g⁻¹, on the Gray Range 47.1 ng g⁻¹, on the Kakaruk Range 42.2 ng g⁻¹, and 41.7 ng g⁻¹on the Noyakuk Range. Lichen Hg levels on St. Lawrence Island was 46.6 ng g⁻¹. Methyl mercury levels in lichens were found to be below detection levels. Reindeer grazing on these ranges had mean Hg hair levels of 14.6 ng g⁻¹(Davis herd), 83.4 ng g⁻¹(Gray herd), and 40.3 ng g⁻¹(Noyakuk herd). Two reindeer on St. Lawrence Island had an average of Hg of 43.0 ng g⁻¹. Sample sizes ranged from n = 2 to n = 11. Hg mean levels in lichen on Seward Peninsula were higher than Hg means of two ranges in northern Mongolia. The Hg levels observed in this study indicate that Hg levels in Alaska are low at this time and pose no risk to the health of reindeer or human subsistence harvesters. A significant relationship between Hg in lichens on the ranges and the Hg in reindeer on those ranges has not been established. There are insufficient data on Hg levels in many areas of the north and more information is needed on location specific and time trends in Hg concentrations. Lichens and reindeer hair provide a good, non-invasive method of monitoring metal exposure changes in Alaskan ecosystems.