The present study was designed to assess the potential of oral myofunctional therapy (OMFT) for improving respiration parameters, Apnea-Hypopnea Index (AHI), and saturation of peripheral oxygen (SpO2) during sleep. The Epworth Sleepiness Scale (ESS) was administered to 92 students in class time at the Nihon University School of Dentistry at Matsudo. The results showed that 15 students had a high ESS. Of the 15 students who had learnt about their excessive sleepiness, six students expressed their intention to receive treatment for their sleep condition. They volunteered as subjects for the study. The Lip Trainer Patakara(®) was used for labial closure force (LCF) training for 2 months. LCF, AHI and SPO2 during sleep were measured before training and after 2 months training. The paired t-test was applied for statistical analyses. LCFs before and 2 months after training were 8.8 ± 1.6 and 12.9 ± 0.6N, respectively. LCF significantly increased after training compared to that before training. SpO2 before training and after training were 90.0 ± 2.9% and 96.8±0.8%, respectively. SpO2 after training was significantly increased compared to that before training. AHI before and after training were 15.1 ± 3.4 and 9.2 ± 1.5 events/h, respectively. AHI after training was significantly decreased compared to that before training. From this study, the following conclusions were made: (1) OMFT significantly increases LCF; and (2) the AHI and SpO2 during sleep are significantly improved after OMFT.

In Lusaka, Zambia, rotavirus (RV) and human immunodeficiency virus (HIV) infection commonly coexist; 132 (25%) of 537 consecutively studied infants .05), and infants with both viruses more frequently experienced dehydration (P < .05). HIV-infected children more often exhibited respiratory symptoms on admission to the study (P < .0001) and were more frequently underweight (P < .0001) than were HIV-negative children, independent of RV infection. The mortality rate was highest in HIV-positive infants (P < .05), and coinfection with RV did not increase the risk of fatality. This study demonstrates that while RV and HIV infections commonly coexist in one region of Africa, RV infection is no more common nor is the illness more severe in HIV-positive infants.

The examination of jaw movement during exercise is essential for an improved understanding of jaw function. Currently, there is no unified view of the mechanism by which the mandible is fixed during physical exercise. We hypothesized that during strong skeletal muscle force exertion in dynamic exercises, the mandible is displaced to a position other than the maximal intercuspal position and that mouth-opening and mouth-closing muscles simultaneously contract to fix the displaced mandible. Therefore, we simultaneously recorded mandibular jaw movements and masticatory muscle activities during dynamic trunk muscle force exertion (deadlift exercise) in 24 healthy adult males (age, 27.3 ± 2.58 years). The deadlift was divided into three steps: Ready (reference), Pull, and Down. During Pull, the mandibular incisal point moved significantly posteriorly (−0.24 mm, p = 0.023) and inferiorly (−0.55 mm, p = 0.019) from the maximal intercuspal position. Additionally, temporal, masseter, and digastric muscles were activated simultaneously and significantly during Pull (18.63 ± 17.13%, 21.21 ± 18.73%, 21.82 ± 19.97% of the maximum voluntary contraction, respectively), with maintained activities during Down (p < 0.001). Thus, during dynamic trunk muscle force exertion, the mandibular incisal point moved to a posteroinferior position without tooth-touch (an open-mouth position). Simultaneously, the activities of the mouth-opening digastric muscles and the mouth-closing temporal and masseter muscles led to mandibular fixation, which is a type of mandible fixing called bracing.

We conducted a multicenter survey for oral appliance (OA) therapy to grasp and analyze the current situation of OA therapy, including efficacy, side effects, and follow-up, in Japan. The Japanese cross-sectional multicenter survey (JAMS) for obstructive sleep apnea (OSA) was undertaken by patients in 10 institutions associated with oral appliance therapy during two years, from 2014 to 2015, retrospectively. Age, sex, body mass index (BMI), baseline apnea–hypopnea index (AHI), OA type, adjustment, adverse reactions with OA, and AHI with OA were elicited from the patient clinical record. The number of included OSA patients was 3217. The number of patients with OA therapy was 2947. We evaluated 1600 patients for the OA treatment. The patients treated with OA, both male and female, were most commonly in their 50s. In terms of OSA severity, snoring was 2.3%, mild was 38.5%, moderate was 39.9%, and severe was 19.3%. The use of mono bloc appliance was 91.8%, bi bloc appliance was 7.9%, and tongue-retaining device (TRD) was 0.3%. After OA treatment, AHI decreased from 22.4/h to 9.3/h. The AHI reduction rate with OA was 52.0%. The rate of AHI <5 with OA was 35.6%. Adverse reactions developed in 14.7% of the subjects. OA reassessment was conducted for 54.3%. This study revealed the current situation of efficacy and side effects of OA therapy, and the problem that the reassessment rate of OA was low in Japan.