With the continually increasing mining depths, heat stress and spontaneous combustion hazards in high-temperature mines are becoming increasingly severe. Mining production risks from natural hazards and exposures to hot and humid environments can cause occupational diseases and other work-related injuries. Liquid nitrogen injection, an engineering control developed to reduce heat stress and spontaneous combustion hazards in mines, was successfully utilized for environmental cooling and combustion prevention in an underground mining site named “Y120205 Working Face” (Y120205 mine) of Yangchangwan colliery. Both localized humidities and temperatures within the Y120205 mine decreased significantly with liquid nitrogen injection. The maximum percentage drop in temperature and humidity of the Y120205 mine were 21.9% and 10.8%, respectively. The liquid nitrogen injection system has the advantages of economical price, process simplicity, energy savings and emission reduction. The optimized heat exchanger used in the liquid nitrogen injection process achieved superior air-cooling results, resulting in considerable economic benefits.