The aim of this work was to prepare a nanoemulsion containing the essential oil of Protium heptaphyllum resin and to evaluate the larvicidal activity and the residual larvicidal effect against Aedes aegypti. The essential oil was identified by gas chromatography coupled to a mass spectrometer, and the nanoemulsions were prepared using a low-energy method and characterized by photon correlation spectroscopy. The results indicated the major constituents as p-cimene (27.70%) and α-Pinene (22.31%). Nanoemulsions had kinetic stability and a monomodal distribution in a hydrophilic-lipophilic balance of 14 with particle diameters of 115.56 ± 1.68 nn and zeta potential of −29.63 ± 3.46 mV. The nanoemulsion showed larvicidal action with LC₅₀ = 2.91 µg∙mL⁻¹ and residual larvicidal effect for 72 h after application to A. aegypti larvae. Consequently, the nanobiotechnological product derived from the essential oil of P. heptaphyllum resin could be used against infectious disease vectors.

This work aimed to prepare a nanoemulsion containing the essential oil of the Protium heptaphyllum resin and evaluate its biocidal activities against the different stages of development of the Aedes aegypti mosquito. Ovicide, pupicide, adulticide and repellency assays were performed. The main constituents were p-cymene (27.70%) and α-pinene (22.31%). The developed nanoemulsion showed kinetic stability and monomodal distribution at a hydrophilic–lipophilic balance of 14 with a droplet size of 115.56 ± 1.68 nn and a zeta potential of −29.63 ± 3.46 mV. The nanoemulsion showed insecticidal action with LC₅₀ 0.404 µg·mL⁻¹ for the ovicidal effect. In the pupicidal test, at the concentration of 160 µg·mL⁻¹, 100% mortality was reached after 24 h. For adulticidal activity, a diagnostic concentration of 200 µg·mL⁻¹ (120 min) was determined. In the repellency test, a concentration of 200 µg·mL⁻¹ during the 180 min of the test showed a protection index of 77.67%. In conclusion, the nanobiotechnological product derived from the essential oil of P. heptaphyllum resin can be considered as a promising colloid that can be used to control infectious disease vectors through a wide range of possible modes of applications, probably as this bioactive delivery system may allow the optimal effect of the P. heptaphyllum terpenes in aqueous media and may also induce satisfactory delivery to air interfaces.

Ayapana triplinervis is a plant species used in traditional medicine and in mystical-religious rituals by traditional communities in the Amazon. The aim of this study is to evaluate the larvicidal activity against A. aegypti of nano-emulsions containing essential oils from A. triplinervis morphotypes, and acute oral toxicity in non-target organism. Essential oils were identified and nano-emulsions were prepared using the low energy method. The mortality test of A. aegypti larvae was performed according to the protocol recommended by the World Health Organization, and toxicity in non-target mammals was performed according to the OECD. Phytochemical analyses indicated the major compounds (E)-Caryophyllene (45.93%) and Thymohydroquinone Dimethyl Ether (32.93%) in morphotype A, and in morphotype B, Thymohydroquinone Dimethyl Ether (84.53%) was found. Morphotype A essential oil nano-emulsion showed a particle size of 101.400 ± 0.971 nm (PdI = 0.124 ± 0.009 and ZP = −19,300 ± 0.787 mV). Morphotype B essential oil nano-emulsion had a particle size of 104.567 ± 0.416 nm (PdI = 0.168 ± 0.016 and ZP = −27,700 ± 1,307 mV). Histomorphological analyses showed the presence of inflammatory cells in the liver of animals treated with morphotype A essential oil nano-emulsion (MAEON) and morphotype B essential oil nano-emulsion (MBEON). Congestion and the presence of transudate with leukocyte infiltration in the lung of animals treated with MAEON were observed. The nano-emulsions containing essential oils of A. triplinervis morphotypes showed an effective nanobiotechnological product in the chemical control of A. aegypti larvae and safe for non-target mammals.

Analisar a tendência temporal da obesidade em adultos usuários da Atenção Primaria à Saúde (APS) do Sistema Único de Saúde (SUS), no período 2008 a 2023. Estudo ecológico de séries temporais, com dados do Sisvan Web; a variação média anual (vma) foi estimada pelo método de regressão de Prais-Winsten. No período em estudo aumentaram as percentagens da obesidade no Brasil e em todas as UF. As vma revelam tendência de aumento, estatisticamente significativa, das percentagens da obesidade; vma maiores à média global (1,323/ano), observou-se entre as UF de Alagoas (1,505/ano), Ceará (1,519/ano), Pernambuco (1,379/ano), Rio Grande do Norte (1,506/ano) e Sergipe (1,443/ano) da região Nordeste e Goiás (1,343/ano) da região Centro-Oeste. Tal cenário requer, além da ação conjunta dos setores responsáveis, maior compromisso da população, para se tornarem mais ativas fisicamente, bem como a opção por alimentação mais saudável.

O Transtorno do Espectro Autista (TEA) é uma condição caracterizada por alterações significativas no desenvolvimento social, comunicativo e comportamental, exigindo intervenções terapêuticas especializadas e precoces. Dentre as abordagens que têm se destacado na literatura científica, o Modelo Denver de Intervenção Precoce (Early Start Denver Model – ESDM) emerge como uma proposta baseada em evidências, integrando princípios do desenvolvimento infantil, da análise do comportamento aplicada e das práticas naturalísticas. A Psicologia desempenha um papel central nesse contexto, ao compreender as necessidades específicas do desenvolvimento infantil e articular estratégias de intervenção que potencializem as competências cognitivas, sociais e comunicativas da criança com TEA.Este estudo teve como objetivo analisar a eficácia do ESDM no desenvolvimento de crianças com TEA, especialmente aquelas que se encontram sem diagnóstico confirmado ou aguardando tratamento especializado. Para tanto, realizou-se uma pesquisa de caráter descritivo, com abordagem qualitativa, mediante revisão bibliográfica em bases nacionais e internacionais, tais como PePSIC, SciELO e PubMed, além de repositórios institucionais e dados governamentais. A escolha metodológica se justifica pela necessidade de reunir e sintetizar as evidências existentes sobre os efeitos do ESDM em diferentes contextos, ampliando o entendimento sobre a aplicabilidade do modelo em realidades diversas.Os resultados apontaram que a intervenção precoce com o ESDM promove benefícios significativos para o desenvolvimento global de crianças com TEA, mesmo quando aplicada em contextos de baixa intensidade, como ambientes escolares e familiares. Dentre os ganhos observados destacam-se a melhora da linguagem expressiva e receptiva, avanços na cognição, no comportamento adaptativo e na interação social, bem como a redução da gravidade dos sintomas característicos do espectro autista. Tais achados corroboram a importância de políticas públicas que favoreçam o diagnóstico precoce e a oferta de tratamentos especializados, reforçando o papel da Psicologia no delineamento de práticas terapêuticas que respeitem as especificidades do desenvolvimento infantil.Conclui-se que o ESDM é uma ferramenta eficaz no contexto da intervenção precoce, sendo fundamental para minimizar os impactos do TEA e promover a qualidade de vida das crianças e suas famílias. Recomenda-se, ainda, a realização de estudos adicionais no Brasil, a fim de fortalecer a base empírica nacional e ampliar o acesso a práticas baseadas em evidências no campo da Psicologia do Desenvolvimento.

Autism Spectrum Disorder (ASD) is a condition characterized by significant changes in social, communicative, and behavioral development, requiring early and specialized therapeutic interventions. Among the approaches that have stood out in the scientific literature, the Early Start Denver Model (ESDM) emerges as an evidence-based proposal, integrating principles of child development, applied behavior analysis, and naturalistic practices. Psychology plays a central role in this context, by understanding the specific needs of child development and articulating intervention strategies that enhance the cognitive, social, and communicative skills of children with ASD. This study aimed to analyze the effectiveness of ESDM in the development of children with ASD, especially those who have not been diagnosed or are awaiting specialized treatment. To this end, a descriptive research was carried out, with a qualitative approach, through a bibliographic review in national and international databases, such as PePSIC, SciELO, and PubMed, in addition to institutional repositories and government data. The methodological choice is justified by the need to gather and synthesize the existing evidence on the effects of ESDM in different contexts, expanding the understanding of the applicability of the model in different realities. The results showed that early intervention with ESDM promotes significant benefits for the overall development of children with ASD, even when applied in low-intensity contexts, such as school and family environments. Among the gains observed, we highlight the improvement in expressive and receptive language, advances in cognition, adaptive behavior and social interaction, as well as the reduction in the severity of symptoms characteristic of the autistic spectrum. These findings corroborate the importance of public policies that favor early diagnosis and the provision of specialized treatments, reinforcing the role of Psychology in the design of therapeutic practices that respect the specificities of child development. It is concluded that ESDM is an effective tool in the context of early intervention, being essential to minimize the impacts of ASD and promote the quality of life of children and their families. It is also recommended that additional studies be carried out in Brazil in order to strengthen the national empirical base and expand access to evidence-based practices in the field of Developmental Psychology.