Deep learning-based methods have achieved remarkable success in image restoration and enhancement, but are they still competitive when there is a lack of paired training data? As one such example, this paper explores the low-light image enhancement problem, where in practice it is extremely challenging to simultaneously take a low-light and a normal-light photo of the same visual scene. We propose a highly effective unsupervised generative adversarial network, dubbed EnlightenGAN, that can be trained without low/normal-light image pairs, yet proves to generalize very well on various real-world test images. Instead of supervising the learning using ground truth data, we propose to regularize the unpaired training using the information extracted from the input itself, and benchmark a series of innovations for the low-light image enhancement problem, including a global-local discriminator structure, a self-regularized perceptual loss fusion, and the attention mechanism. Through extensive experiments, our proposed approach outperforms recent methods under a variety of metrics in terms of visual quality and subjective user study. Thanks to the great flexibility brought by unpaired training, EnlightenGAN is demonstrated to be easily adaptable to enhancing real-world images from various domains. Our codes and pre-trained models are available at: https://github.com/VITA-Group/EnlightenGAN.

We present a comprehensive study and evaluation of existing single-image dehazing algorithms, using a new large-scale benchmark consisting of both synthetic and real-world hazy images, called REalistic Single-Image DEhazing (RESIDE). RESIDE highlights diverse data sources and image contents, and is divided into five subsets, each serving different training or evaluation purposes. We further provide a rich variety of criteria for dehazing algorithm evaluation, ranging from full-reference metrics to no-reference metrics and to subjective evaluation, and the novel task-driven evaluation. Experiments on RESIDE shed light on the comparisons and limitations of the state-of-the-art dehazing algorithms, and suggest promising future directions.

This paper proposes an image dehazing model built with a convolutional neural network (CNN), called All-in-One Dehazing Network (AOD-Net). It is designed based on a re-formulated atmospheric scattering model. Instead of estimating the transmission matrix and the atmospheric light separately as most previous models did, AOD-Net directly generates the clean image through a light-weight CNN. Such a novel end-to-end design makes it easy to embed AOD-Net into other deep models, e.g., Faster R-CNN, for improving high-level tasks on hazy images. Experimental results on both synthesized and natural hazy image datasets demonstrate our superior performance than the state-of-the-art in terms of PSNR, SSIM and the subjective visual quality. Furthermore, when concatenating AOD-Net with Faster R-CNN, we witness a large improvement of the object detection performance on hazy images.

Drug discovery demands rapid quantification of compound–protein interaction (CPI). However, there is a lack of methods that can predict compound–protein affinity from sequences alone with high applicability, accuracy and interpretability. We present a seamless integration of domain knowledges and learning-based approaches. Under novel representations of structurally annotated protein sequences, a semi-supervised deep learning model that unifies recurrent and convolutional neural networks has been proposed to exploit both unlabeled and labeled data, for jointly encoding molecular representations and predicting affinities. Our representations and models outperform conventional options in achieving relative error in IC₅₀ within 5-fold for test cases and 20-fold for protein classes not included for training. Performances for new protein classes with few labeled data are further improved by transfer learning. Furthermore, separate and joint attention mechanisms are developed and embedded to our model to add to its interpretability, as illustrated in case studies for predicting and explaining selective drug–target interactions. Lastly, alternative representations using protein sequences or compound graphs and a unified RNN/GCNN-CNN model using graph CNN (GCNN) are also explored to reveal algorithmic challenges ahead. Data and source codes are available at https://github.com/Shen-Lab/DeepAffinity. Supplementary data are available at Bioinformatics online.

Existing enhancement methods are empirically expected to help the high-level end computer vision task: however, that is observed to not always be the case in practice. We focus on object or face detection in poor visibility enhancements caused by bad weathers (haze, rain) and low light conditions. To provide a more thorough examination and fair comparison, we introduce three benchmark sets collected in real-world hazy, rainy, and low-light conditions, respectively, with annotated objects/faces. We launched the UG2+ challenge Track 2 competition in IEEE CVPR 2019, aiming to evoke a comprehensive discussion and exploration about whether and how low-level vision techniques can benefit the high-level automatic visual recognition in various scenarios. To our best knowledge, this is the first and currently largest effort of its kind. Baseline results by cascading existing enhancement and detection models are reported, indicating the highly challenging nature of our new data as well as the large room for further technical innovations. Thanks to a large participation from the research community, we are able to analyze representative team solutions, striving to better identify the strengths and limitations of existing mindsets as well as the future directions.