Biosensing and tactile sensing are considered to be essential functions for intelligent diagnostic medical robot. In this paper, biosensing and tactile sensing had been demonstrated with a single photonic crystal structure. The flexible and stretchable photonic crystal structure consists of PDMS as the flexible substrate and TiO₂ as the guided layer, and the nanograting structure was realized by nanoreplica molding. For biosensing experiment, a sensitivity of 93 nm/RIU is verified with ambient environment RI variance simulation results. For tactile sensing experiment, the highest resolution for strain sensing is 0.1%, and the minimum detected scale of the grating period variation is 0.1 nm. The TiO2/PDMS structure based flexible and stretchable photonic crystal sensor demonstrates highly sensitivity and potentially cost effective for biosensing and tactile sensing, and it is promising in the area of intelligent diagnostic medical robot.

Based on the related characteristics of optical waveguide and flexible optical materials, a flexible and stretchable optical waveguide structure oriented to tactile perception is proposed. The sensing principle of optical waveguide is based on mechanical deformation caused by output light loss. It overcomes the shortcomings of traditional optical waveguide devices, which are unable to conform to irregular surface. The flexible and stretchable optical waveguide is fabricated with nanoreplica molding method, and it has been applied to the measurement of pressure and strain in the field of tactile sensing. The flexible and stretchable optical waveguide had a strain detection range of 0 to 12.5%, and the external force detection range is from 0 to 23 × 10^–3 N.

Carbendazim and acetamidine are pesticides that widely used to control pests and diseases in oilseed rape. In this paper, a rapid, accurate and reliable method was proposed for the detection of carbendazim and acetamidine with SERS microfluidic chip technology. Ag-ps(Polystyrene microspheres) microsphere SERS substrate was prepared by spin coating and magnetron sputtering deposition of Ag. The enhancement factor of prepared SERS substrate was 2.4 × 10¹⁰. The SERS detection working curves were well fitted and the linear parameters R² were 0.987 and 0.994, respectively. The limit of detection was 0.01 mg/mL. The use of SERS microfluidic chip to detect carbendazim and acetamidine is expected to provide a way for the detection of pesticide residues in crops, which has broad application prospects in the field of food safety.

Raman spectroscopy can quickly achieve non-destructive, qualitative and quantitative detection, and analysis the molecular structure of substances. Herein, a facile and low-cost method for preparation of highly sensitivity SERS substrates was implemented through the displacement reaction of copper foam immersed in AgNO₃ ethanol solution. Due to the 3D structure of copper film and homogenous displacement, the Ag–Cu substrate showed high performance SERS enhancement (1.25 × 10⁷), and the lowest detection concentration for R6G reached 10^–10 Mol/L. For glucose detection, mixed decanethiol (DT)/mercaptohexanol (MH) interlayer was used to enable glucose attach to the substrate surface, and the limit of detection reached to 1 uM/L. SERS substrate makes the Ag–Cu SERS substrate promising for biological applications.