Several studies have evaluated the relationship between malondialdehyde (MDA) concentrations and Plasmodium infections; however, the findings remain inconclusive. This study synthesized differences in MDA concentrations among patients with different levels of clinical severity, uninfected controls, and different Plasmodium species. The research protocol was registered in PROSPERO (CRD42023393540). Systematic literature searches for relevant studies were performed using the Embase, MEDLINE, Ovid, ProQuest, PubMed, Scopus, and Google Scholar databases. Qualitative and quantitative syntheses (meta-analyses) of distinct MDA concentrations between the disease groups were performed. Twenty-three studies met the eligibility criteria and were included in the systematic review. Overall, MDA concentrations were significantly elevated in participants with malaria relative to uninfected controls (p < 0.01, Cohen d: 2.51, 95% confidence interval (CI): 1.88–3.14, I²: 96.22%, 14 studies). Increased MDA concentrations in participants with malaria compared with uninfected controls were found in studies that enrolled patients with P. falciparum malaria (p < 0.01, Cohen d: 2.50, 95% CI: 1.90–3.10, I²: 89.7%, 7 studies) and P. vivax malaria (p < 0.01, Cohen d: 3.70, 95% CI: 2.48–4.92, I²: 90.11%, 3 studies). Our findings confirm that MDA concentrations increase during Plasmodium infection, indicating a rise in oxidative stress and lipid peroxidation. Thus, MDA levels can be a valuable biomarker for evaluating these processes in individuals with malaria. However, further research is necessary to fully elucidate the intricate relationship between malaria, antioxidants, oxidative stress, and the specific role of MDA in the progression of malaria.

The assessment of muscle strength by hand grip strength (HGS) is used to evaluate muscle weakness and wasting among stroke patients. This study aimed to investigate the association of oxidative stress/oxidative damage and inflammatory biomarkers with muscle strength and wasting, as evaluated by HGS, among community-dwelling post-stroke patients. The HGS of both paretic and non-paretic limbs was negatively associated with modified Rankin scale (mRS) values. The serum levels of catalase activity and malondialdehyde (MDA), and plasma tumor necrosis factor (TNF)-α levels were significantly increased in post-stroke patients compared with non-stroke controls. Further analysis highlighted that hydrogen peroxide was positively correlated with HGS in the paretic limbs. Interestingly, an elevated MDA level, excluding advanced age and high mRS, increased the risk of low HGS in the non-paretic limbs of stroke patients. This study suggests that there is a detrimental association between MDA and muscle strength and early muscle wasting among post-stroke patients. Hence, MDA is a potentially useful biomarker of muscle weakness and wasting in post-stroke patients living in the community.

This study investigated the effects of eye exercises on eye-hand coordination, cognitive function, and balance in sixty elderly participants aged 60–70 years who were randomly assigned to an experimental or control group. The experimental group performed Gaze Stability Exercises (GSE) for 50 min per session, while the control group performed eyeball exercises for 10 min. Both groups trained twice a week for four weeks. Assessments of eye-hand coordination, cognitive function, and balance were conducted before and after the intervention. An Analysis of Covariance (ANCOVA), adjusting for baseline scores and gender, was used for between-group comparisons. ANCOVA revealed that the GSE group showed significantly greater improvements in cognitive function and dynamic balance compared to the control group (p < 0.05). However, no significant difference was found between the groups for eye-hand coordination. Within-group comparisons showed that both groups improved in eye-hand coordination and cognitive function (p < 0.05). These findings suggest that eye exercises, including GSEs and eyeball exercises, can enhance eye-hand coordination and cognitive function in elderly individuals. The dynamic balance improvements observed only in the experimental group highlight the potential of GSEs in balance training. Preliminary findings indicate that consistent eye exercise help improve motor and cognitive skills in the elderly, which requires further study.

Background: The evidence of superoxide dismutase (SOD) in the pathogenesis of malaria is inconsistent. The present study aimed to synthesize the evidence of blood levels of SOD in patients with malaria and determine the association of blood levels of SOD with the severity of malaria. Methods: The study protocol was PROSPERO-registered (CRD42023393806). The searches for relevant articles were conducted in MEDLINE, Embase, Scopus, Ovid, PubMed, and Google Scholar. The syntheses of (i) the different blood levels of SOD between individuals with and without malaria and (ii) the different blood levels of SOD between individuals with severe and non-severe malaria were performed. The effect estimate (Cohen's d) and 95% confidence interval (CI) were pooled using a random-effects model. Results: A total of 1874 articles were retrieved from database searches and 28 studies were included in the review. The blood levels of SOD were lower in individuals with malaria compared to those without malaria infection (P < 0.01, Cohen's d: -2.06, 95% CI: -2.99– (-1.14), I2: 98.96%, 2181 malaria cases/1186 uninfected cases). There were no differences in blood levels of SOD between severe and non-severe malaria patients (P = 0.09, Cohen's d: -1.57, 95% CI: -3.39– 0.26), I2: 96.02%, 69 severe malaria cases/256 non-severe malaria cases). Conclusions: The blood levels of SOD were lower in malaria patients compared to those without malaria infection. Further studies will be required to determine the extent to which SOD might prevent Plasmodium infections during pregnancy.

This study investigated academic and environmental predictors of national licensing examination success among physical therapy graduates in Thailand, examining overall academic achievement, domain-specific competencies (Code 01: Law/Ethics/Administration; Code 02: Techniques; Code 03: Clinical), admission pathway, and COVID-19-related online-learning disruption. This retrospective cohort study analyzed 342 graduates (2020–2023) using multivariable logistic regression and Pearson correlation, with GPA-based predictors rescaled per 0.1-point increase. Undergraduate GPAX and Code 02/03 grades were the strongest positive predictors of both first-attempt and annual licensing success (adjusted OR range 1.35–1.74, all p < 0.001). Online-learning duration reduced first-attempt odds by 24% (OR = 0.757, p = 0.036) but did not affect annual success, while TCAS admission round was a significant negative predictor of first-attempt success only in the model excluding domain-specific scores (OR = 0.671, p = 0.011); Code 01 score was not significant in any model. These findings indicate that domain-specific academic performance, rather than general achievement or admission pathway, was the strongest predictor of licensing success, underscoring the value of early monitoring of coursework performance for identifying at-risk students.