The spatiotemporal structure of wind-driven circulation patterns and associated water exchanges can drive important bio-hydrodynamic interactions in shallow lagoons. The Vaccarès lagoon system is a complex shallow hydrosystem located in the central part of the Rhône Delta (France). It is internationally recognized as part of a biosphere reserve within the framework of UNESCO’s Man and Biosphere Programme, and as a RAMSAR site. Due to its frequent occurrence in this area, and considering the shallowness of the Vaccarès lagoon system, wind is assumed to play a major role in the hydrodynamic and biological processes. In this study, a hydrodynamic model was developed to investigate the structure of wind-driven circulations in the Vaccarès lagoon system, to provide insights into their role in transport and water exchange processes. The implementation and assessment (calibration and validation) of the model is presented first. Simulations were then performed for two typical steady wind conditions and for one measured unsteady wind event. The results illustrate the influence of the complex geometry of the Vaccarès lagoon system on the wind-driven circulations, and the differences observed between the different sub-lagoons in this system. The differences in wind-induced water exchanges between these sub-lagoons are also discussed.

Industrial production of therapeutic monoclonal antibodies is mostly performed in eukaryotic-based systems, allowing posttranslational modifications mandatory for their functional activity. The resulting elevated product cost limits therapy access to some patients. To address this limitation, we conceptualized a novel immunotherapeutic approach to redirect a preexisting polyclonal antibody response against Epstein-Barr virus (EBV) toward defined target cells. We engineered and expressed in bacteria bimodular fusion proteins (BMFPs) comprising an Fc-deficient binding moiety targeting an antigen expressed at the surface of a target cell, fused to the EBV-P18 antigen, which recruits circulating endogenous anti-P18 IgG in EBV ⁺ individuals. Opsonization of BMFP-coated targets efficiently triggered antibody-mediated clearing effector mechanisms. When assessed in a P18-primed mouse tumor model, therapy performed with an anti-huCD20 BMFP significantly led to increased survival and total cancer remission in some animals. These results indicate that BMFPs could represent potent and useful therapeutic molecules to treat a number of diseases.

The deep-water commercial port to be built, object of this paper, is an island port which will be served by a sea access bridge supported by piles. These piles are submitted to three types of forces: inertia forces, drag forces and wave breaking forces. As the first two type can be accurately approximated theoretically, the third one is highly dependent of the wave shape in the vicinity of the pile. As a consequence, in order to determine the hydrodynamic forces on the various piles of this bridge, a three-stages methodology was set up. An analysis of the loads was first carried out theoretically, the second stage consisted in carrying out physical model tests for a selected pile and in a third stage a numerical model was used. The paper will discuss the means and programme of the tests, and in particular the selection of characteristic waves and the results obtained.