Large variability and correlations among the coefficients obtained from the method of geographically weighted regression (GWR) have been identified in previous research. This is an issue that poses a serious challenge for the utility of the method as a tool to investigate multivariate relationships. The objectives of this paper are to assess: (1) the ability of GWR to discriminate between a spatially constant processes and one with spatially varying relationships; and (2) to accurately retrieve spatially varying relationships. Extensive numerical experiments are used to investigate situations where the underlying process is stationary and nonstationary, and to assess the degree to which spurious intercoefficient correlations are introduced. Two different implementations of GWR and cross-validation approaches are assessed. Results suggest that judicious application of GWR can be used to discern whether the underlying process is nonstationary. Furthermore, evidence of spurious correlations indicates that caution must be exercised when drawing conclusions regarding spatial relationships retrieved using this approach, particularly when working with small samples.

Exploring spatial-temporal patterns of disease incidence through cluster analysis identifies areas of significantly elevated or decreased risk, providing potential clues about disease risk factors. Little is known about the etiology of non-Hodgkin lymphoma (NHL), or the latency period that might be relevant for environmental exposures, and there are no published spatial-temporal cluster studies of NHL.

Despite the recent publication of results from two randomized clinical trials, prostate specific antigen (PSA) screening for prostate cancer remains a controversial issue. There is lack of agreement across studies that PSA screening significantly reduces prostate cancer mortality. In spite of these facts, the widespread use of PSA testing in the United States leads to overdetection and overtreatment of clinically indolent prostate cancer, and its associated harms of incontinence and impotence.