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Background In the last decades, the relationship between social networking sites (SNSs) and older people’s loneliness is gaining specific relevance. Studies in this field are often based on qualitative methods to study in-depth self-perceived issues, including loneliness and well-being, or quantitative surveys to report the links between information and communication technologies (ICTs) and older people’s well-being or loneliness. However, these nonexperimental methods are unable to deeply analyze the causal relationship. Moreover, the research on older people’s SNS use is still scant, especially regarding its impact on health and well-being. In recent years, the existing review studies have separately focused their attention on loneliness and social isolation of older people or on the use of ICTs and SNSs in elderly populations without addressing the relationship between the former and the latter. This thorough qualitative review provides an analysis of research performed using an experimental or quasi-experimental design that investigates the causal effect of ICT and SNS use on elderly people’s well-being related to loneliness. Objective The aims of this review are to contrast and compare research designs (sampling and recruitment, evaluation tools, interventions) and the findings of these studies and highlight their limitations. Methods Using an approach that integrates the methodological framework for scoping studies and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews, we identified 11 articles that met our inclusion criteria. A thematic and content analysis was performed based on the ex post categorization of the data on the selected studies, and the data were summarized in tables. Results The analysis of the selected articles showed that: (1) ICT use is positively but weakly related to the different measures of older people’s well-being and loneliness, (2) overall, the studies under review lack a sound experimental design, (3) the main limitations of these studies lie in the lack of rigor in the sampling method and in the recruitment strategy. Conclusions The analysis of the reviewed studies confirms the existence of a beneficial effect of ICT use on the well-being of older people in terms of reduced loneliness. However, the causal relationship is often found to be weak. This review highlights the need to study these issues further with adequate methodological rigor.
Georgia Casanova; Daniele Zaccaria; Elena Rolandi; Antonio Guaita. The Effect of Information and Communication Technology and Social Networking Site Use on Older People’s Well-Being in Relation to Loneliness: Review of Experimental Studies. Journal of Medical Internet Research 2021, 23, e23588 .
AMA StyleGeorgia Casanova, Daniele Zaccaria, Elena Rolandi, Antonio Guaita. The Effect of Information and Communication Technology and Social Networking Site Use on Older People’s Well-Being in Relation to Loneliness: Review of Experimental Studies. Journal of Medical Internet Research. 2021; 23 (3):e23588.
Chicago/Turabian StyleGeorgia Casanova; Daniele Zaccaria; Elena Rolandi; Antonio Guaita. 2021. "The Effect of Information and Communication Technology and Social Networking Site Use on Older People’s Well-Being in Relation to Loneliness: Review of Experimental Studies." Journal of Medical Internet Research 23, no. 3: e23588.
Few studies have examined lockdown effects on the way of living and well-being of older adults stratified by cognitive state. Since cognitive deficits are common in this population, we investigated how cognition influenced their understanding of the pandemic, socio-behavioral responses and lifestyle adaptations during lockdown, and how these factors affected their mood or memory. Telephone-based survey involving 204 older adults ≥65 y/o (median: 82) with previous assessments of cognitive state: 164 normal-old (NOLD), 24 mild-neurocognitive disorder (mild-NCD), 18 mild-moderate dementia. A structured questionnaire was developed to assess psychological and socio-behavioral variables. Logistic regression was used to ascertain their effects on mood and memory. With increasing cognitive deficits, understanding of the pandemic and the ability to follow lockdown policies, adapt to lifestyle changes, and maintain remote interactions decreased. Participants with dementia were more depressed; NOLDs remained physically and mentally active but were more bored and anxious. Sleeping and health problems independently increased the likelihood of depression (OR: 2.29; CI: 1.06–4.93; p = 0.034 and OR: 2.45; CI: 1.16–5.16; p = 0.018, respectively); Regular exercise was protective (OR: 0.30; CI: 0.12–0.72; p = 0.007). Worsening subjective memory complaints were associated with dementia (p = 0.006) and depression (p = 0.004); New-onset sleeping problems raised their odds (OR: 10.26; CI: 1.13–93.41; p = 0.039). Finally, >40% with health problems avoided healthcare mainly due to fear of contagion. NOLD and mild-NCD groups showed similar mood-behavioral profiles suggesting better tolerance of lockdown. Those with dementia were unable to adapt and suffered from depression and cognitive complaints. To counteract lockdown effects, physical and mental activities and digital literacy should be encouraged.
Arenn Faye Carlos; Tino Emanuele Poloni; Martina Caridi; Marco Pozzolini; Roberta Vaccaro; Elena Rolandi; Alice Cirrincione; Laura Pettinato; Silvia Francesca Vitali; Livio Tronconi; Mauro Ceroni; Antonio Guaita. Life during COVID-19 lockdown in Italy: the influence of cognitive state on psychosocial, behavioral and lifestyle profiles of older adults. Aging & Mental Health 2021, 1 -10.
AMA StyleArenn Faye Carlos, Tino Emanuele Poloni, Martina Caridi, Marco Pozzolini, Roberta Vaccaro, Elena Rolandi, Alice Cirrincione, Laura Pettinato, Silvia Francesca Vitali, Livio Tronconi, Mauro Ceroni, Antonio Guaita. Life during COVID-19 lockdown in Italy: the influence of cognitive state on psychosocial, behavioral and lifestyle profiles of older adults. Aging & Mental Health. 2021; ():1-10.
Chicago/Turabian StyleArenn Faye Carlos; Tino Emanuele Poloni; Martina Caridi; Marco Pozzolini; Roberta Vaccaro; Elena Rolandi; Alice Cirrincione; Laura Pettinato; Silvia Francesca Vitali; Livio Tronconi; Mauro Ceroni; Antonio Guaita. 2021. "Life during COVID-19 lockdown in Italy: the influence of cognitive state on psychosocial, behavioral and lifestyle profiles of older adults." Aging & Mental Health , no. : 1-10.
Background Older people are at greater risk of infection and mortality from COVID‐19 and 52.3% of the deceased in Italy are Lombardy’s residents. Moreover, lockdown measurements may disproportionately affect elderly, since they are less familiar with communication technology used to overcome the lack of in person social contacts. The present study aimed at exploring how older adults residing in Lombardy are experiencing the lockdown period, in relation to loneliness, social isolation and use of communication technology. Method In the first two weeks of May (2020) a telephone interview was conducted with people aged between 81 and 85, residing in the community, who participated in a study aimed at evaluating the impact of Social Networking Sites (SNS) use and older people’s social relationship (clinicaltrials.gov: NCT04242628). We collected information on SNS use, self‐perceived loneliness (UCLA scale 3‐item), social engagement with family and friends (Lubben Social Network Scale 6‐item). Among the eligible individuals (N=144), 1 deceased, 4 refused and 9 were unreachable, resulting in a sample of 130 interviewed. For the aim of the present investigation, participants were stratified as trained (N=60) and untrained (N=70) for SNS use, based on their attendance to group courses held last year as part of the main experimental study. Result Trained and untrained participants were comparable for age, sex, education, percentage of living alone, global cognition, depressive symptoms and comorbidity (Table 1). Participants trained for SNS use reported significantly higher usage of Facebook and WhatsApp and reduced feeling of being left out during the COVID‐19 lockdown (Table 2). Moreover, a trend toward significance was found for an inverse relationship between WhatsApp usage frequency and feeling of lack of companionship (rs = ‐0.257, p = 0.051; Table 3). Conclusion Though SNS are unable to completely replace in person contact, these preliminary results support the utility to train older adults for SNS use in order to improve their social inclusion, even in extreme conditions of self‐isolation and vulnerability due to COVID‐19 pandemic.
Elena Rolandi; Roberta Vaccaro; Simona Abbondanza; Georgia Casanova; Laura Pettinato; Mauro Colombo; Antonio Guaita. Loneliness and social engagement in older adults based in Lombardy during COVID‐19 lockdown: The long‐term effects of social networking sites training course. Alzheimer's & Dementia 2020, 16, 1 .
AMA StyleElena Rolandi, Roberta Vaccaro, Simona Abbondanza, Georgia Casanova, Laura Pettinato, Mauro Colombo, Antonio Guaita. Loneliness and social engagement in older adults based in Lombardy during COVID‐19 lockdown: The long‐term effects of social networking sites training course. Alzheimer's & Dementia. 2020; 16 (uppl 7):1.
Chicago/Turabian StyleElena Rolandi; Roberta Vaccaro; Simona Abbondanza; Georgia Casanova; Laura Pettinato; Mauro Colombo; Antonio Guaita. 2020. "Loneliness and social engagement in older adults based in Lombardy during COVID‐19 lockdown: The long‐term effects of social networking sites training course." Alzheimer's & Dementia 16, no. uppl 7: 1.
Older adults are less familiar with communication technology, which became essential to maintain social contacts during the COVID-19 lockdown. The present study aimed at exploring how older adults, previously trained for Social Networking Sites (SNSs) use, experienced the lockdown period. In the first two weeks of May 2020, telephone surveys were conducted with individuals aged 81–85 years and resident in Abbiategrasso (Milan), who previously participated in a study aimed at evaluating the impact of SNSs use on loneliness in old age (ClinicalTrials.gov, NCT04242628). We collected information on SNSs use, self-perceived loneliness, and social engagement with family and friends. Interviewed participants were stratified as trained (N = 60) and untrained (N = 70) for SNSs use, based on their attendance to group courses held the previous year as part of the main experimental study. The groups were comparable for sociodemographics and clinical features. Participants trained for SNSs use reported significantly higher usage of SNSs and reduced feeling of being left out. Compared to pre-lockdown levels, individuals trained for SNSs use showed a lighter reduction in social contacts. These findings support the utility of training older adults for SNSs use in order to improve their social inclusion, even in extreme conditions of self-isolation and perceived vulnerability.
Elena Rolandi; Roberta Vaccaro; Simona Abbondanza; Georgia Casanova; Laura Pettinato; Mauro Colombo; Antonio Guaita. Loneliness and Social Engagement in Older Adults Based in Lombardy during the COVID-19 Lockdown: The Long-Term Effects of a Course on Social Networking Sites Use. International Journal of Environmental Research and Public Health 2020, 17, 7912 .
AMA StyleElena Rolandi, Roberta Vaccaro, Simona Abbondanza, Georgia Casanova, Laura Pettinato, Mauro Colombo, Antonio Guaita. Loneliness and Social Engagement in Older Adults Based in Lombardy during the COVID-19 Lockdown: The Long-Term Effects of a Course on Social Networking Sites Use. International Journal of Environmental Research and Public Health. 2020; 17 (21):7912.
Chicago/Turabian StyleElena Rolandi; Roberta Vaccaro; Simona Abbondanza; Georgia Casanova; Laura Pettinato; Mauro Colombo; Antonio Guaita. 2020. "Loneliness and Social Engagement in Older Adults Based in Lombardy during the COVID-19 Lockdown: The Long-Term Effects of a Course on Social Networking Sites Use." International Journal of Environmental Research and Public Health 17, no. 21: 7912.
BACKGROUND In the last decades, the relationship between social networking sites (SNSs) and older people’s loneliness is gaining specific relevance. Studies in this field are often based on qualitative methods to study in-depth self-perceived issues, including loneliness and well-being, or quantitative surveys to report the links between information and communication technologies (ICTs) and older people’s well-being or loneliness. However, these nonexperimental methods are unable to deeply analyze the causal relationship. Moreover, the research on older people’s SNS use is still scant, especially regarding its impact on health and well-being. In recent years, the existing review studies have separately focused their attention on loneliness and social isolation of older people or on the use of ICTs and SNSs in elderly populations without addressing the relationship between the former and the latter. This thorough qualitative review provides an analysis of research performed using an experimental or quasi-experimental design that investigates the causal effect of ICT and SNS use on elderly people’s well-being related to loneliness. OBJECTIVE The aims of this review are to contrast and compare research designs (sampling and recruitment, evaluation tools, interventions) and the findings of these studies and highlight their limitations. METHODS Using an approach that integrates the methodological framework for scoping studies and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews, we identified 11 articles that met our inclusion criteria. A thematic and content analysis was performed based on the ex post categorization of the data on the selected studies, and the data were summarized in tables. RESULTS The analysis of the selected articles showed that: (1) ICT use is positively but weakly related to the different measures of older people’s well-being and loneliness, (2) overall, the studies under review lack a sound experimental design, (3) the main limitations of these studies lie in the lack of rigor in the sampling method and in the recruitment strategy. CONCLUSIONS The analysis of the reviewed studies confirms the existence of a beneficial effect of ICT use on the well-being of older people in terms of reduced loneliness. However, the causal relationship is often found to be weak. This review highlights the need to study these issues further with adequate methodological rigor.
Georgia Casanova; Daniele Zaccaria; Elena Rolandi; Antonio Guaita. The Effect of Information and Communication Technology and Social Networking Site Use on Older People’s Well-Being in Relation to Loneliness: Review of Experimental Studies (Preprint). 2020, 1 .
AMA StyleGeorgia Casanova, Daniele Zaccaria, Elena Rolandi, Antonio Guaita. The Effect of Information and Communication Technology and Social Networking Site Use on Older People’s Well-Being in Relation to Loneliness: Review of Experimental Studies (Preprint). . 2020; ():1.
Chicago/Turabian StyleGeorgia Casanova; Daniele Zaccaria; Elena Rolandi; Antonio Guaita. 2020. "The Effect of Information and Communication Technology and Social Networking Site Use on Older People’s Well-Being in Relation to Loneliness: Review of Experimental Studies (Preprint)." , no. : 1.
An ageing society poses unprecedented challenges to societies. Information and Communication Technologies (ICTs), including Social Networking Sites (SNSs), may contribute to contrast loneliness and social isolation in old age. Despite of the potentialities of SNSs, there is only a handful of studies assessing the causal relationship of SNS use and older people's well-being. This paper aims to provide further evidence on the design of randomised controlled trials exploring the causal impact of SNS use on loneliness and social isolation in old age. The Aging in a Networked Society-Social Experiment Study (ANS-SE) is a randomised controlled trial conducted on people aged 75 and over residing in a town located in the Milan area (Italy) aiming to assess the impact of SNS use on loneliness and social isolation (i.e. the primary outcomes of this study). The study is constituted of two stages, i.e. the baseline and the follow up. The experiment is structured into one treatment group and two control groups; the interventions are the attendance to a course on SNS use (T1) and lifestyle education and brain functioning (C1). The inactive control group (C) is constituted of a waiting list. We will perform bivariate and regression analysis. The study has been approved by the Ethic Committee of the University of Milano Bicocca (prot. 431/2019) and was registered at Clinical Trials.gov (NCT04242628). Written consent was obtained from all respondents. Results from the study will be discussed with the local community and stakeholders, presented in national and international conferences and published in leading peer-review journals. The consent forms, the anonymised dataset, and the relevant statistical codes will be deposited with the Italian Unidata archive, also in charge of releasing the data to the public, upon a short embargo period.
Daniele Zaccaria; Antonio Guaita; Roberta Vaccaro; Georgia Casanova; Simona Abbondanza; Laura Pettinato; Gabriele Cerati; Elena Rolandi; Emanuela Sala. Assessing the impact of Social Networking Site use on older people's loneliness and social isolation. A randomized controlled trial: The Aging in a Networked Society-Social Experiment Study (ANS-SE). Contemporary Clinical Trials Communications 2020, 19, 100615 -100615.
AMA StyleDaniele Zaccaria, Antonio Guaita, Roberta Vaccaro, Georgia Casanova, Simona Abbondanza, Laura Pettinato, Gabriele Cerati, Elena Rolandi, Emanuela Sala. Assessing the impact of Social Networking Site use on older people's loneliness and social isolation. A randomized controlled trial: The Aging in a Networked Society-Social Experiment Study (ANS-SE). Contemporary Clinical Trials Communications. 2020; 19 ():100615-100615.
Chicago/Turabian StyleDaniele Zaccaria; Antonio Guaita; Roberta Vaccaro; Georgia Casanova; Simona Abbondanza; Laura Pettinato; Gabriele Cerati; Elena Rolandi; Emanuela Sala. 2020. "Assessing the impact of Social Networking Site use on older people's loneliness and social isolation. A randomized controlled trial: The Aging in a Networked Society-Social Experiment Study (ANS-SE)." Contemporary Clinical Trials Communications 19, no. : 100615-100615.
Alzheimer’s Disease (AD) is a multifactorial disorder driven by genetic and modifiable lifestyle risk factors. Lifestyle primary prevention initiatives may reduce the prevalence and incidence of dementia in older adults. The E.Mu.N.I study is a randomized controlled trial investigating the effect of multilevel non-pharmacologic interventions on cognitive performances (primary outcome) and structural and vascular brain MRI markers (secondary outcome), as well as markers of brain functional connectivity change (exploratory outcome), in older adults with subjective memory decline (SMD). Here, we present the study design and the baseline features of the sample. Cognitively intact older adults with SMD, enrolled between February 2016 and June 2017, were randomly assigned to one of the 3 interventions for 1 year: Active Control Intervention (ACI), i.e., educational lessons; Partial Intervention (PI), i.e., homotaurine administration (100 mg/die) and lessons on the Mediterranean diet; Multilevel Intervention (MI), i.e., PI plus computerized cognitive training and physical exercise training. One-hundred and twenty-eight eligible participants were enrolled (66% female; age: 68 ± 5 years). Eighty-two percent of the sample was composed of volunteers with SMD from the community. Participants were randomly allocated to the interventions as follows: ACI (N = 40), PI (N = 44), MI (N = 44). No significant differences among groups emerged on socio-demographic, clinical–neuropsychological variables and MRI markers at baseline. The outcomes obtained from the E.Mu.N.I. study will clarify the efficacy of multilevel non-pharmacologic interventions on cognitive and neuroimaging markers in SMD individuals. This is a crucial step forward for the development of cost-effective non-pharmacologic primary prevention initiatives for AD.
Elena Rolandi; Alessandra Dodich; Samantha Galluzzi; Clarissa Ferrari; Sara Mandelli; Federica Ribaldi; Giulio Munaretto; Claudia Ambrosi; Roberto Gasparotti; Davide Violi; Nicola Canessa; Sandro Iannaccone; Alessandra Marcone; Andrea Falini; Harald Hampel; Giovanni B. Frisoni; Chiara Cerami; Enrica Cavedo. Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study. Aging Clinical and Experimental Research 2019, 32, 817 -826.
AMA StyleElena Rolandi, Alessandra Dodich, Samantha Galluzzi, Clarissa Ferrari, Sara Mandelli, Federica Ribaldi, Giulio Munaretto, Claudia Ambrosi, Roberto Gasparotti, Davide Violi, Nicola Canessa, Sandro Iannaccone, Alessandra Marcone, Andrea Falini, Harald Hampel, Giovanni B. Frisoni, Chiara Cerami, Enrica Cavedo. Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study. Aging Clinical and Experimental Research. 2019; 32 (5):817-826.
Chicago/Turabian StyleElena Rolandi; Alessandra Dodich; Samantha Galluzzi; Clarissa Ferrari; Sara Mandelli; Federica Ribaldi; Giulio Munaretto; Claudia Ambrosi; Roberto Gasparotti; Davide Violi; Nicola Canessa; Sandro Iannaccone; Alessandra Marcone; Andrea Falini; Harald Hampel; Giovanni B. Frisoni; Chiara Cerami; Enrica Cavedo. 2019. "Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study." Aging Clinical and Experimental Research 32, no. 5: 817-826.
The aim of the study was to investigate the association between postoperative delirium (POD) and in vivo markers of Alzheimer's disease pathology in nondemented hip fracture surgery patients. POD was assessed with the Confusion Assessment Method. Amyloid load was quantified on 18F-Flutemetamol positron emission tomography images as standardized uptake value ratio. Secondary outcome measures were gray matter volumes, white matter integrity, and functional connectivity at rest. All the patients with POD (POD+, N = 5) were amyloid negative (standardized uptake value ratio <0.59), whereas 6 out of 11 patients without POD (POD-) showed brain amyloid positivity. POD+ compared to POD- displayed: lower gray matter volumes in the amygdala (p = 0.003), in the middle temporal gyrus and in the anterior cingulate cortex (p < 0.001), increased diffusivity in the genu of the corpus callosum and in the anterior corona radiata (p < 0.05), and higher functional connectivity within the default mode network (p < 0.001). POD patients showed altered gray and white matter integrity in the fronto-limbic regions in absence of brain amyloidosis. Based on this preliminary investigation, delirium pathophysiology might be independent of Alzheimer's disease. Future studies on larger samples are needed to confirm this hypothesis.
Elena Rolandi; Enrica Cavedo; Michela Pievani; Samantha Galluzzi; Federica Ribaldi; Christopher Buckley; Colm Cunningham; Ugo Paolo Guerra; Monica Musarra; Sabrina Morzenti; Silvia Magnaldi; Mirko Patassini; Flavio Terragnoli; Luca Matascioli; Simone Franzoni; Giorgio Annoni; Lucio Carnevali; Giuseppe Bellelli; Giovanni B. Frisoni. Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study. Neurobiology of Aging 2018, 61, 93 -101.
AMA StyleElena Rolandi, Enrica Cavedo, Michela Pievani, Samantha Galluzzi, Federica Ribaldi, Christopher Buckley, Colm Cunningham, Ugo Paolo Guerra, Monica Musarra, Sabrina Morzenti, Silvia Magnaldi, Mirko Patassini, Flavio Terragnoli, Luca Matascioli, Simone Franzoni, Giorgio Annoni, Lucio Carnevali, Giuseppe Bellelli, Giovanni B. Frisoni. Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study. Neurobiology of Aging. 2018; 61 ():93-101.
Chicago/Turabian StyleElena Rolandi; Enrica Cavedo; Michela Pievani; Samantha Galluzzi; Federica Ribaldi; Christopher Buckley; Colm Cunningham; Ugo Paolo Guerra; Monica Musarra; Sabrina Morzenti; Silvia Magnaldi; Mirko Patassini; Flavio Terragnoli; Luca Matascioli; Simone Franzoni; Giorgio Annoni; Lucio Carnevali; Giuseppe Bellelli; Giovanni B. Frisoni. 2018. "Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study." Neurobiology of Aging 61, no. : 93-101.
The human trapeziometacarpal (TMC) joint has a crucial evolutionary importance as it permits rotation and opposition of the thumb to the other fingers. In chronic TMC joint osteoarthritis (i.e., rhizarthrosis), this motor ability, essential for pinching, grasping, and manipulating objects, may become difficult or impossible due to intolerable pain. Here, we assess whether patients with rhizarthrosis show signs of abnormal brain representation of hand movements. To this end, we studied 35 patients with rhizarthrosis, affecting predominantly one of the two hands, and 35 healthy subjects who underwent both behavioural and fMRI measures of brain activity during overtly executed or imagined thumb-to-finger-opposition movements. The patients with rhizarthrosis were slower than controls both in motor execution and imagination. In the patients, correlation between the motor execution and imagination times was preserved, even though such correlation was less strong than in normal controls. The fMRI measures showed reduced activation in the hand primary motor and dorsal premotor cortex for the patients only during explicit movements. This was true for both hands, yet more so for the most affected hand. No significant differences were seen for the motor imagery task. These results show that an orthopaedic disorder that reduces patients' motoric repertoire in the absence of any neurological impairment is sufficient to induce neurofunctional changes in the cortical representation of hand movements. The substantial preservation of motor imagery with its neural counterparts distinguishes the neurological patterns of rhizarthrosis from those of complete immobilization or amputation suggesting that motor imagery may be used to boost motor recovery in rhizarthrosis after surgical treatment.
Martina Gandola; Maurilio Bruno; Laura Zapparoli; Gianluca Saetta; Elena Rolandi; Antonio De Santis; Giuseppe Banfi; Alberto Zerbi; Valerio Sansone; Eraldo Paulesu. Functional brain effects of hand disuse in patients with trapeziometacarpal joint osteoarthritis: executed and imagined movements. Experimental Brain Research 2017, 235, 3227 -3241.
AMA StyleMartina Gandola, Maurilio Bruno, Laura Zapparoli, Gianluca Saetta, Elena Rolandi, Antonio De Santis, Giuseppe Banfi, Alberto Zerbi, Valerio Sansone, Eraldo Paulesu. Functional brain effects of hand disuse in patients with trapeziometacarpal joint osteoarthritis: executed and imagined movements. Experimental Brain Research. 2017; 235 (10):3227-3241.
Chicago/Turabian StyleMartina Gandola; Maurilio Bruno; Laura Zapparoli; Gianluca Saetta; Elena Rolandi; Antonio De Santis; Giuseppe Banfi; Alberto Zerbi; Valerio Sansone; Eraldo Paulesu. 2017. "Functional brain effects of hand disuse in patients with trapeziometacarpal joint osteoarthritis: executed and imagined movements." Experimental Brain Research 235, no. 10: 3227-3241.
Lifetime commitment in cognitive activities confers increased brain resilience against aging and neurodegenerative disease, a phenomenon named cognitive reserve (CR). Thus, the investigation of CR in population at risk for Alzheimer’s Disease is of great interest. Aim of the present study was to investigate the neural and cognitive correlates of cognitive reserve in elderly with subjective cognitive decline (SCD). Preliminary results are shown.
Elena Rolandi; Ilaria Stella; Samantha Galluzzi; Federica Ribaldi; Claudia Ambrosi; Roberto Gasparotti; Harald Hampel; Giovanni B. Frisoni; Enrica Cavedo. NEURAL AND COGNITIVE CORRELATES OF COGNITIVE RESERVE IN SUBJECTIVE COGNITIVE DECLINE. Alzheimer's & Dementia 2017, 13, P929 .
AMA StyleElena Rolandi, Ilaria Stella, Samantha Galluzzi, Federica Ribaldi, Claudia Ambrosi, Roberto Gasparotti, Harald Hampel, Giovanni B. Frisoni, Enrica Cavedo. NEURAL AND COGNITIVE CORRELATES OF COGNITIVE RESERVE IN SUBJECTIVE COGNITIVE DECLINE. Alzheimer's & Dementia. 2017; 13 (7):P929.
Chicago/Turabian StyleElena Rolandi; Ilaria Stella; Samantha Galluzzi; Federica Ribaldi; Claudia Ambrosi; Roberto Gasparotti; Harald Hampel; Giovanni B. Frisoni; Enrica Cavedo. 2017. "NEURAL AND COGNITIVE CORRELATES OF COGNITIVE RESERVE IN SUBJECTIVE COGNITIVE DECLINE." Alzheimer's & Dementia 13, no. 7: P929.
Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.
Pradeep J. Nathan; Yen Ying Lim; Rosemary Abbott; Samantha Galluzzi; Moira Marizzoni; Claudio Babiloni; Diego Albani; David Bartrés-Faz; Mira Didic; Lucia Farotti; Lucilla Parnetti; Nicola Salvadori; Bernhard W. Müller; Gianluigi Forloni; Nicola Girtler; Tilman Hensch; Jorge Jovicich; Annebet Leeuwis; Camillo Marra; José Luis Molinuevo; Flavio Nobili; Jeremie Pariente; Pierre Payoux; Jean-Philippe Ranjeva; Elena Rolandi; Paolo Maria Rossini; Peter Schönknecht; Andrea Soricelli; Magda Tsolaki; Pieter Jelle Visser; Jens Wiltfang; Jill C. Richardson; Régis Bordet; Olivier Blin; Giovanni B. Frisoni. Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI). Neurobiology of Aging 2017, 53, 1 -10.
AMA StylePradeep J. Nathan, Yen Ying Lim, Rosemary Abbott, Samantha Galluzzi, Moira Marizzoni, Claudio Babiloni, Diego Albani, David Bartrés-Faz, Mira Didic, Lucia Farotti, Lucilla Parnetti, Nicola Salvadori, Bernhard W. Müller, Gianluigi Forloni, Nicola Girtler, Tilman Hensch, Jorge Jovicich, Annebet Leeuwis, Camillo Marra, José Luis Molinuevo, Flavio Nobili, Jeremie Pariente, Pierre Payoux, Jean-Philippe Ranjeva, Elena Rolandi, Paolo Maria Rossini, Peter Schönknecht, Andrea Soricelli, Magda Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C. Richardson, Régis Bordet, Olivier Blin, Giovanni B. Frisoni. Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI). Neurobiology of Aging. 2017; 53 ():1-10.
Chicago/Turabian StylePradeep J. Nathan; Yen Ying Lim; Rosemary Abbott; Samantha Galluzzi; Moira Marizzoni; Claudio Babiloni; Diego Albani; David Bartrés-Faz; Mira Didic; Lucia Farotti; Lucilla Parnetti; Nicola Salvadori; Bernhard W. Müller; Gianluigi Forloni; Nicola Girtler; Tilman Hensch; Jorge Jovicich; Annebet Leeuwis; Camillo Marra; José Luis Molinuevo; Flavio Nobili; Jeremie Pariente; Pierre Payoux; Jean-Philippe Ranjeva; Elena Rolandi; Paolo Maria Rossini; Peter Schönknecht; Andrea Soricelli; Magda Tsolaki; Pieter Jelle Visser; Jens Wiltfang; Jill C. Richardson; Régis Bordet; Olivier Blin; Giovanni B. Frisoni. 2017. "Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)." Neurobiology of Aging 53, no. : 1-10.
Background In the field of Alzheimer's disease (AD), the validation of biomarkers for early AD diagnosis and for use as a surrogate outcome in AD clinical trials is of considerable research interest. Objective To characterize the clinical profile and genetic, neuroimaging and neurophysiological biomarkers of prodromal AD in amnestic mild cognitive impairment (aMCI) patients enrolled in the IMI WP5 PharmaCog (also referred to as the European ADNI study). Methods A total of 147 aMCI patients were enrolled in 13 European memory clinics. Patients underwent clinical and neuropsychological evaluation, magnetic resonance imaging (MRI), electroencephalography (EEG) and lumbar puncture to assess the levels of amyloid β peptide 1–42 (Aβ42), tau and p‐tau, and blood samples were collected. Genetic (APOE), neuroimaging (3T morphometry and diffusion MRI) and EEG (with resting‐state and auditory oddball event‐related potential (AO‐ERP) paradigm) biomarkers were evaluated. Results Prodromal AD was found in 55 aMCI patients defined by low Aβ42 in the cerebrospinal fluid (Aβ positive). Compared to the aMCI group with high Aβ42 levels (Aβ negative), Aβ positive patients showed poorer visual (P = 0.001), spatial recognition (P < 0.0005) and working (P = 0.024) memory, as well as a higher frequency of APOE4 (P < 0.0005), lower hippocampal volume (P = 0.04), reduced thickness of the parietal cortex (P < 0.009) and structural connectivity of the corpus callosum (P < 0.05), higher amplitude of delta rhythms at rest (P = 0.03) and lower amplitude of posterior cingulate sources of AO‐ERP (P = 0.03). Conclusion These results suggest that, in aMCI patients, prodromal AD is characterized by a distinctive cognitive profile and genetic, neuroimaging and neurophysiological biomarkers. Longitudinal assessment will help to identify the role of these biomarkers in AD progression.
Samantha Galluzzi; Moira Marizzoni; Claudio Babiloni; Diego Albani; Luigi Antelmi; C. Bagnoli; David Bartrés-Faz; S. Cordone; M. Didic; L. Farotti; U. Fiedler; Gianluigi Forloni; N. Girtler; T. Hensch; Jorge Jovicich; A. Leeuwis; C. Marra; J. L. Molinuevo; Flavio Nobili; J. Pariente; L. Parnetti; Pierre Payoux; C. Del Percio; J.-P. Ranjeva; Elena Rolandi; P. M. Rossini; P. Schönknecht; Andrea Soricelli; M. Tsolaki; Pieter Jelle Visser; Jens Wiltfang; J. C. Richardson; R. Bordet; O. Blin; G. B. Frisoni; the PharmaCog Consortium. Clinical and biomarker profiling of prodromal Alzheimer's disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a ‘European ADNI study’. Journal of Internal Medicine 2016, 279, 576 -591.
AMA StyleSamantha Galluzzi, Moira Marizzoni, Claudio Babiloni, Diego Albani, Luigi Antelmi, C. Bagnoli, David Bartrés-Faz, S. Cordone, M. Didic, L. Farotti, U. Fiedler, Gianluigi Forloni, N. Girtler, T. Hensch, Jorge Jovicich, A. Leeuwis, C. Marra, J. L. Molinuevo, Flavio Nobili, J. Pariente, L. Parnetti, Pierre Payoux, C. Del Percio, J.-P. Ranjeva, Elena Rolandi, P. M. Rossini, P. Schönknecht, Andrea Soricelli, M. Tsolaki, Pieter Jelle Visser, Jens Wiltfang, J. C. Richardson, R. Bordet, O. Blin, G. B. Frisoni, the PharmaCog Consortium. Clinical and biomarker profiling of prodromal Alzheimer's disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a ‘European ADNI study’. Journal of Internal Medicine. 2016; 279 (6):576-591.
Chicago/Turabian StyleSamantha Galluzzi; Moira Marizzoni; Claudio Babiloni; Diego Albani; Luigi Antelmi; C. Bagnoli; David Bartrés-Faz; S. Cordone; M. Didic; L. Farotti; U. Fiedler; Gianluigi Forloni; N. Girtler; T. Hensch; Jorge Jovicich; A. Leeuwis; C. Marra; J. L. Molinuevo; Flavio Nobili; J. Pariente; L. Parnetti; Pierre Payoux; C. Del Percio; J.-P. Ranjeva; Elena Rolandi; P. M. Rossini; P. Schönknecht; Andrea Soricelli; M. Tsolaki; Pieter Jelle Visser; Jens Wiltfang; J. C. Richardson; R. Bordet; O. Blin; G. B. Frisoni; the PharmaCog Consortium. 2016. "Clinical and biomarker profiling of prodromal Alzheimer's disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a ‘European ADNI study’." Journal of Internal Medicine 279, no. 6: 576-591.
The prevalence of Alzheimer's disease (AD) is constantly growing worldwide in absence of any effective treatment. Methodology and technique advancements facilitated the early diagnosis of AD leading to a shift toward preclinical AD stages investigation in order to delay the disease onset in individuals at risk for AD. Recent evidence demonstrating the aging related multifactorial nature of AD supported the hypothesis that modifiable environmental factors can accelerate or delay the disease onset. In particular, healthy dietary habits, constant physical and cognitive activities are associated with reduced brain atrophy, amyloid load and incidence of AD cases. Due to these promising results, an emerging field of studies is currently investigating the efficacy of interventions addressing different lifestyle habits in cognitive intact elderly individuals as a potential preventive strategy against AD onset. We provide a critical overview of the current evidence on nonpharmacologic treatments in elderly individuals, discussing their efficacy on clinical and neuroimaging outcomes and identifying current methodological issues. Future perspectives, relevant for the scientific community and the worldwide public health institutes will be further discussed
Elena Rolandi; Giovanni Battista Frisoni; Enrica Cavedo. Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly. Ageing Research Reviews 2016, 25, 1 -12.
AMA StyleElena Rolandi, Giovanni Battista Frisoni, Enrica Cavedo. Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly. Ageing Research Reviews. 2016; 25 ():1-12.
Chicago/Turabian StyleElena Rolandi; Giovanni Battista Frisoni; Enrica Cavedo. 2016. "Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly." Ageing Research Reviews 25, no. : 1-12.