Wound healing and regeneration are critical in medical care and pose a huge challenge for healthcare systems. It has great significance to develop functional materials for promoting wound repair. Herein, we presented novel antibacterial hydrogel microparticles with drug loading to treat the wound. The chitosan (CS) droplets were generated from a microfluidic electrospray system and solidified by sodium hydroxide solution. With further drying and drug uploading process, the drug-loaded CS microparticles (CSMPs) were achieved. The CSMPs exhibited excellent biocompatibility and antibacterial property, and displayed excellent capability in promoting wound healing in multiple stages. Hence, it is expected that the presented CSMPs can serve as multifunctional dressings for wound healing applications.

Under the stimulation of various response factors, the wound detection and treatment platform enables drugs that bind to biological macromolecules to precisely treat the wound.