Research investigating the effects of exercise as therapy in cystic fibrosis (CF) has demonstrated that exercise can increase aerobic capacity (VO2peak) and exercise tolerance [ 1 x [1] Orenstein, D.M., Franklin, B.A., Doershuk, C.F. et al. Exercise conditioning and cardiopulmonary fitness in cystic fibrosis. The effects of a three-month supervised running program. Chest. 1981; 80: 392–398 Crossref | PubMed | Scopus (142) | Google Scholar See all References ] [1] , facilitate sputum clearance [ 2 x [2] Baldwin, D.R., Hill, A.L., Peckham, D.G., and Knox, A.J. Effect of addition of exercise to chest physiotherapy on sputum expectoration and lung function in adults with cystic fibrosis. Respir Med. 1994; 88: 49–53 Abstract | Full Text PDF | PubMed | Scopus (60) | Google Scholar See all References , 3 x [3] Dwyer, T.J., Alison, J.A., McKeough, Z.J., Daviskas, E., and Bye, P.T. Effects of exercise on respiratory flow and sputum properties in cystic fibrosis. Chest. 2011; 139: 870–877 Crossref | PubMed | Scopus (49) | Google Scholar See all References ], and that individuals with CF with better aerobic fitness have better survival [ 4 x [4] Nixon, P.A., Orenstein, D.M., Kelsey, S.F., and Doershuk, C.F. The prognostic value of exercise testing in patients with cystic fibrosis. N Engl J Med. 1992; 327: 1785–1788 Crossref | PubMed | Scopus (381) | Google Scholar See all References ] [4] . Although exercise is a vital component of the therapy regimen prescribed to individuals with CF, Myers et al. demonstrated that adherence is poor, finding only 24% of adults with CF are completing their exercise program [ 5 x [5] Myers, L.B. An exploratory study investigating factors associated with adherence to chest physiotherapy and exercise in adults with cystic fibrosis. J Cyst Fibros. 2009; 8: 425–427 Abstract | Full Text | Full Text PDF | PubMed | Scopus (22) | Google Scholar See all References ] [5] . Reasons individuals with CF may not make exercise a priority are the belief that exercise is not as beneficial as pharmacological treatments, and not feeling they have the time and/or energy to engage in physical activity [ 6 x [6] Gruber, W., Orenstein, D.M., Braumann, K.M., and Beneke, R. Interval exercise training in cystic fibrosis – effects on exercise capacity in severely affected adults. J Cyst Fibros. 2014; 13: 86–91 Abstract | Full Text | Full Text PDF | PubMed | Scopus (15) | Google Scholar See all References , 7 x [7] Moola, F.J., Faulkner, G.E., and Schneiderman, J.E. “No time to play”: perceptions toward physical activity in youth with cystic fibrosis. Adapt Phys Act Q. 2012; 29: 44–62 PubMed | Google Scholar See all References , 8 x [8] White, D., Stiller, K., and Haensel, N. Adherence of adult cystic fibrosis patients with airway clearance and exercise regimens. J Cyst Fibros. 2007; 6: 163–170 Abstract | Full Text | Full Text PDF | PubMed | Scopus (36) | Google Scholar See all References , 9 x [9] Prasad, S.A. and Cerny, F.J. Factors that influence adherence to exercise and their effectiveness: application to cystic fibrosis. Pediatr Pulmonol. 2002; 34: 66–72 Crossref | PubMed | Scopus (60) | Google Scholar See all References ].