About 3 million stillbirths and 3 million early neonatal deaths occurred worldwide in 2004, 98% of which were in less developed countries.
1 A high perinatal mortality rate was reported in rural China in 2000.
2 Potential preventable causes of stillbirths and early neonatal deaths are maternal anemia and related micronutrient deficiencies.
3 Quiz Ref ID Aside from perinatal folic acid supplements to prevent neural tube defects, multiple health organizations recommend pregnant women routinely receive iron–folic acid supplements to prevent anemia.
4 Meta-analyses of randomized controlled trials (RCTs) indicate that daily prenatal iron–folic acid supplementation prevents iron deficiency and anemia.
5,6 The effect of prenatal iron–folic acid supplementation on perinatal mortality and other maternal and infant outcomes remains unclear, particularly among nonanemic women. Thus, some question the added benefit of prophylactic iron supplementation.
7