Many trials have been conducted to treat atopic dermatitis (AD), but these therapies are generally unsuccessful because of their insufficiency or side effects. This study examined the efficacy of β-glucan derived from oats with fermented probiotics (called Synbio-glucan) on an AD-induced mouse model. For the experiment, Nc/Nga mice were exposed to a house dust mite extract (HDM) to induce AD. The mice were placed in one of four groups: positive control group, Synbio-glucan topical treatment group, Synbio-glucan dietary treatment group, and Synbio-glucan topical + dietary treatment group. The experiment revealed no significant difference in the serum IgE concentration among the groups. Serum cytokine antibody arrays showed that genes related to the immune response were enriched. A significant difference in the skin lesion scores was observed between the groups. Compared to the control group tissue, skin lesions were alleviated in the Synbio-glucan topical treatment group and Synbio-glucan dietary treatment group. Interestingly, almost normal structures were observed within the skin lesions in the Synbio-glucan topical + dietary treatment group. Overall, the β-glucan extracted from oats and fermented probiotic mixture is effective in treating atopic dermatitis.

Kim YH, et al. J Vet Sci. 2019 Oct;21:e59. https://doi.org/10.4142/jvs.2020.21.e59

Acute pancreatitis is an acute inflammatory process in the pancreas that is common in dogs. This study was designed to compare cytokines between healthy dogs and dogs with suspected acute pancreatitis. For the canine cytokine antibody array, three healthy dogs and three dogs with suspected acute pancreatitis were included. Interleukin (IL)-2, IL-6, IL-10, GM-CSF, and TNF-α were not detected in either group based on the results. Conversely, IL-8 (p = 0.035), Monocyte Chemoattractant Protein-1 (MCP)-1 (p = 0.0138), Receptor for Advanced Glycation Endproducts (RAGE) (p = 0.0079), and stem cell factor (SCF) (p = 0.034) were significantly increased in dogs with suspected acute pancreatitis. However, vascular endothelial growth factor (VEGF) (p = 0.6971) did not differ significantly between groups. For the canine serum Enzyme-Linked Immunosorbent Assay (ELISA), eight healthy dogs and eight dogs with suspected acute pancreatitis were included. ELISA revealed that IL-8 (p < 0.0001), MCP-1 (p < 0.0001), RAGE (p = 0.006), and SCF (p = 0.0002) were all significantly upregulated in the experimental group. We confirmed multiple patterns of cytokines in suspected acute pancreatitis of dogs via canine cytokine antibody array using a small quantity of serum. After this procedure, we reevaluated the cytokines, which were significantly increased in dogs with suspected acute pancreatitis, by ELISA, with more samples. Through this study, we confirmed that MCP-1, RAGE, and SCF were newly suggested factors in dogs with suspected acute pancreatitis.

Yoon-Hwan Kim, Yunho Jeong, Ju-Hyun An, Jin-Ok Ahn, Jin-Young Chung. J Vet Clin 2023;40:8-15. https://doi.org/10.17555/jvc.2023.40.1.8

탐색기를 탑재한 유도탄의 중기궤적은 탐색기 시야(FOV : Field-Of-View) 내에서 표적을 탐지하며, 전환 시점에서의 기동성을 최대화하도록 설계하는 것이 요구된다. 유도탄의 비행궤적 최적화 문제는 여러 구속조건이 적용된 비선형 문제로 일반적인 해석해를 도출하기 어렵기 때문에 그 동안 다양한 계산적인 방법들이 제시되어 왔다. 본 논문에서는 추진-활공 유도탄의 중기궤적 최적화 문제를 컨벡스 최적화 기법인 2차 원뿔 프로그래밍을 이용하여 산출하였다. 먼저, 운동방정식의 상태변수를 최소화하기 위해서 제어변수 구속조건이 추가된 제어변수 추가 형태의 운동방정식을 구성하였다. 또한, 자유 종말시간 문제와 추진시간 문제를 대처하기 위하여 정규화된 시간 변수를 독립 변수로 설정하였다. 그리고, 운동방정식과 제어변수 구속조건을 컨벡스 형태로 변환하기 위하여 각각 부분 선형화와 무손실 컨벡스 변환을 적용하였다. 마지막으로, 본 논문에서 제시된 방안의 타당성을 확인하기 위하여 비선형 최적화 프로그래밍 결과와 비교하였다.