With much advancement in the field of nanotechnology, bioengineering, and synthetic biology over the past decade, microscales and nanoscales devices are becoming a reality. Yet the problem of engineering a reliable communication system between tiny devices is still an open problem. At the same time, despite the prevalence of radio communication, there are still areas where traditional electromagnetic waves find it difficult or expensive to reach. Points of interest in industry, cities, and medical applications often lie in embedded and entrenched areas, accessible only by ventricles at scales too small for conventional radio waves and microwaves, or they are located in such a way that directional high frequency systems are ineffective. Inspired by nature, one solution to these problems is molecular communication (MC), where chemical signals are used to transfer information. Although biologists have studied MC for decades, it has only been researched for roughly 10 year from a communication engineering lens. Significant number of papers have been published to date, but owing to the need for interdisciplinary work, much of the results are preliminary. In this survey, the recent advancements in the field of MC engineering are highlighted. First, the biological, chemical, and physical processes used by an MC system are discussed. This includes different components of the MC transmitter and receiver, as well as the propagation and transport mechanisms. Then, a comprehensive survey of some of the recent works on MC through a communication engineering lens is provided. The survey ends with a technology readiness analysis of MC and future research directions.

As two major players in terrestrial wireless communications, Wi-Fi systems and cellular networks have different origins and have largely evolved separately. Motivated by the exponentially increasing wireless data demand, cellular networks are evolving towards a heterogeneous and small cell network architecture, wherein small cells are expected to provide very high capacity. However, due to the limited licensed spectrum for cellular networks, any effort to achieve capacity growth through network densification will face the challenge of severe inter-cell interference. In view of this, recent standardization developments have started to consider the opportunities for cellular networks to use the unlicensed spectrum bands, including the 2.4 GHz and 5 GHz bands that are currently used by Wi-Fi, Zigbee and some other communication systems. In this article, we look into the coexistence of Wi-Fi and 4G cellular networks sharing the unlicensed spectrum. We introduce a network architecture where small cells use the same unlicensed spectrum that Wi-Fi systems operate in without affecting the performance of Wi-Fi systems. We present an almost blank subframe (ABS) scheme without priority to mitigate the co-channel interference from small cells to Wi-Fi systems, and propose an interference avoidance scheme based on small cells estimating the density of nearby Wi-Fi access points to facilitate their coexistence while sharing the same unlicensed spectrum. Simulation results show that the proposed network architecture and interference avoidance schemes can significantly increase the capacity of 4G heterogeneous cellular networks while maintaining the service quality of Wi-Fi systems.

In this work, we describe the first modular, and programmable platform capable of transmitting a text message using chemical signalling – a method also known as molecular communication. This form of communication is attractive for applications where conventional wireless systems perform poorly, from nanotechnology to urban health monitoring. Using examples, we demonstrate the use of our platform as a testbed for molecular communication, and illustrate the features of these communication systems using experiments. By providing a simple and inexpensive means of performing experiments, our system fills an important gap in the molecular communication literature, where much current work is done in simulation with simplified system models. A key finding in this paper is that these systems are often nonlinear in practice, whereas current simulations and analysis often assume that the system is linear. However, as we show in this work, despite the nonlinearity, reliable communication is still possible. Furthermore, this work motivates future studies on more realistic modelling, analysis, and design of theoretical models and algorithms for these systems.

This article examines recent research in molecular communications from a telecommunications system design perspective. In particular, it focuses on channel models and state-of-the-art physical layer techniques. The goal is to provide a foundation for higher layer research and motivation for research and development of functional prototypes. In the first part of the article, we focus on the channel and noise model, comparing molecular and radio-wave pathloss formulae. In the second part, the article examines, equipped with the appropriate channel knowledge, the design of appropriate modulation and error correction coding schemes. The third reviews transmitter and receiver side signal processing methods that suppress inter-symbol interference. Taken together, the three parts present a series of physical layer techniques that are necessary to produce reliable and practical molecular communications.

Molecular communications (MC) has been studied as a bio-inspired information carrier for micro-scale and nano-scale environments. On the macro-scale, it can also be considered as an alternative to electromagnetic (EM) wave based systems, especially in environments where there is significant attenuation to EM wave power. This paper goes beyond the unbounded free space propagation to examine three macro-scale environments: the pipe, the knife edge, and the mesh channel. Approximate analytical expressions shown in this paper demonstrate that MC has an advantage over EM wave communications when: 1) the EM frequency is below the cut-off frequency for the pipe channel, 2) the EM wavelength is considerably larger than the mesh period, and 3) when the receiver is in the high diffraction loss region of an obstacle.

In the fifth-generation (5G) mobile networks, proactive network optimisation plays an important role in meeting the exponential traffic growth, more stringent service requirements, and to reduce capital and operational expenditure. Proactive network optimisation is widely acknowledged as one of the most promising ways to transform the 5G network based on big data analysis and cloud-fog-edge computing, but there are many challenges. Proactive algorithms will require accurate forecasting of highly contextualised traffic demand and quantifying the uncertainty to drive decision making with performance guarantees. Context in Cyber-Physical-Social Systems (CPSS) is often challenging to uncover, unfolds over time, and even more difficult to quantify and integrate into decision making. The first part of the review focuses on mining and inferring CPSS context from heterogeneous data sources, such as online user-generated-content. It will examine the state-of-the-art methods currently employed to infer location, social behaviour, and traffic demand through a cloud-edge computing framework; combining them to form the input to proactive algorithms. The second part of the review focuses on exploiting and integrating the demand knowledge for a range of proactive optimisation techniques, including the key aspects of load balancing, mobile edge caching, and interference management. In both parts, appropriate state-of-the-art machine learning techniques (including probabilistic uncertainty cascades in proactive optimisation), complexity-performance trade-offs, and demonstrative examples are presented to inspire readers. This survey couples the potential of online big data analytics, cloud-edge computing, statistical machine learning, and proactive network optimisation in a common cross-layer wireless framework. The wider impact of this survey includes better cross-fertilising the academic fields of data analytics, mobile edge computing, AI, CPSS, and wireless communications, as well as informing the industry of the promising potentials in this area.