Research shows that physiological signals can provide objective data support for the analysis of human emotions. At present, non-contact heart rate data have been employed in the research of medicine, intelligent transportation, smart education, etc. However, it is hard to detect heart rate data using non-contact traditional methods during head rotation, especially when face information is missing in scenarios such as online teaching/learning. Traditional remote photoplethysmography (rPPG) methods require a static, full frontal face within a fixed distance for heart rate detection. These strict requirements make it impractical to measure heart rate data in real-world scenarios, as a lot of videos only partially record the subjects’ face information, such as profile, too small distance, and wearing a mask. The current algorithm aims to solve the problem of head deflections between 30 degrees and 45 degrees by employing a symmetry substitution method, which can replace the undetected region of interest (ROI) with the detectable one. When face information is partially missing, our algorithm uses face–eye location to determine ROI. The results show that the method in this paper can solve certain practical problems related to heart rate detection, with a root mean square error (RMSE) under 7.64 bpm.