Seaweeds are some of the largest producers of biomass in the marine environment and are rich in bioactive compounds that are often used for human and animal health. Porphyran and carrageenan are natural compounds derived from red seaweeds. The former is a characteristic polysaccharide of Porphyra, while the latter is well known from Chondrus, Gigartina, and various Eucheuma species, all in Rhodophyceae. The two polysaccharides have been found to have anti-cancer activity by improving immunity and targeting key apoptotic molecules and therefore deemed as potential chemotherapeutic or chemopreventive agents. This review attempts to review the current study of anti-cancer activity and the possible mechanisms of porphyran and carrageenan derived from red seaweeds to various cancers, and their cooperative actions with other anti-cancer chemotherapeutic agents is also discussed.

Oxidative stress induces various cardiovascular, neurodegenerative, and cancer diseases, caused by excess reactive oxygen species (ROS). It is attributed to the lack of sufficient antioxidant defense capacity to eliminate unnecessary ROS. Seaweeds are largely cultivated for their edible and commercial purposes. Excessive proliferation of some seaweeds has occurred in coastal areas, causing environmental and economic disasters, and even threating human health. Removing and disposing of the excess seaweeds are costly and labor-intensive with few rewards. Therefore, improving the value of seaweeds utilizes this resource, but also deals with the accumulated biomass in the environment. Seaweed has been demonstrated to be a great source of polysaccharides antioxidants, which are effective in enhancing the antioxidant system in humans and animals. They have been reported to be a healthful method to prevent and/or reduce oxidative damage. Current studies indicate that they have a good potential for treating various diseases. Polysaccharides, the main components in seaweeds, are commonly used as industrial feedstock. They are readily extracted by aqueous and acetone solutions. This study attempts to review the current researches related to seaweed polysaccharides as an antioxidant. We discuss the main categories, their antioxidant abilities, their determinants, and their possible molecular mechanisms of action. This review proposes possible high-value ways to utilize seaweed resources.

Nonylphenol (NP) is a contaminant that has negative impacts on aquatic organisms. To investigate its phytotoxicity, bioaccumulation, and degradation in algae without associated bacteria, six freshwater microalgae—Ankistrodesmus acicularis, Chlorella vulgaris, Chroococcus minutus, Scenedesmus obliquus, Scenedesmus quadricauda, and Selenastrum bibraianum—in bacteria-free cultures were studied. When exposed to 0.5–3.0 mg L⁻¹ NP for 4 days, cell growth and photosynthesis, including maximal photochemistry (Fv/Fm), were suppressed progressively. The antioxidant responses of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) showed species differences. While the antioxidant enzymes in C. vulgaris and S. obliquus were more active with the increase of NP (0–3 mg L⁻¹), they dropped in the other four algae at concentrations of 1 and 1.5 mg L⁻¹. Therefore, C. vulgaris and S. obliquus were designated as NP-tolerant species and showed more conspicuous and faster changes of antioxidant reactions compared with the four NP-sensitive species. All six species degraded NP, but A. acicularis was more reactive at low NP concentrations (<1 mg L⁻¹), suggesting its possible application in sewage treatment for its potential for effective NP removal from water bodies in a suitable scope. Therefore, the conclusion is that biodegradation of NP by algae is species specific.