Background. In Ethiopia, chronic liver disease (CLD) is the 7th leading cause of death, accounting for about 24 deaths per 100000 populations in 2019. Despite its burden, there is a lack of compiled pieces of evidence on CLD in the country. Thus, this systematic review and meta‐analysis is intended to provide the pooled estimates of CLD etiologies and mortality rate in CLD patients in Ethiopia. Method. PubMed, Google Scholar, ScienceDirect, institutional repositories, national digital library, and the bibliography of the eligible articles information were the source of data for the present review. The keywords “hepatitis, chronic” [Mesh], “end‐Stage Liver Disease” [Mesh], “chronic liver disease”, “liver cirrhosis” [Mesh], and “Ethiopia” were used for the searches. Overall, we retrieved 199 records and 12 were included in this review. We used the DerSimonian‐Laird random‐effects models to perform the meta‐analysis. We conducted subgroup and meta‐regression analyses to account for the heterogeneity of the estimates. Result. Hepatitis B virus, alcohol, and hepatitis C virus are the three most common etiologies of CLD in Ethiopia accounting for a pooled estimate of 40.0% [95% CI: 29.0, 51.0, I² = 96.3, p < 0.001], 17.0% [95% CI: 9.0, 25.0, I² = 96.7, p < 0.001], and 15.0% [95% CI: 9.0, 21.0, I² = 95.8, p < 0.001], respectively. Unidentified etiology report has a substantial contribution accounting for an estimated pooled proportion of 45% [95% CI: 34.0, 56.0%, Q = 32.08, p < 0.001, I² = 87.53] of the CLD cases in the country. On the other hand, the overall hospital mortality rate in CLD patients is 25.0% [95% CI: 2.0, 47.0, I² = 94.6, p < 0.001] in Ethiopia. Conclusion. Hepatitis B virus, hepatitis C virus, and alcohol are the three most common contributors to CLD cases in Ethiopia. The authors warrant routine screening and strengthening of preventive and treatment programs for viral hepatitis B and C, further enhancing the alcohol policy of the country.

Background: Logistics management information system enables the users to gain the right data, in the right quantity, in the right quality, at the right time, to the right place, and for the right cost. Without a logistics management information system, programs inevitably waste valuable resources. Methods: A facility-based descriptive cross-sectional study supplemented with a qualitative method was conducted in selected public health facilities of East Gojjam zone from March 21 to April 23, 2018. Twenty health facilities (15 health centers and 5 hospitals) were included in the study, and we selected randomly health facilities in proportion to their size. Data collectors were collected quantitative data through a physical count and document review. Key informants were selected using the purposive sampling technique and one of the researchers conducted an in-depth interview. Semi-structured questionnaires and observational checklists were used to collect relevant data. Quantifiable data entered EpiData software version 3.1 and exported to SPSS version 20 for analysis. The qualitative data were analyzed using a thematic analysis method. Results: The result showed that the availability and utilization of bin card records and report and requisition reports were 20 (100%). Out of 640 bin card records reviewed, 408 (63.8%) had accurate data ranged from 40 to 100% at hospitals and 20 to 86.6% at health centers. Likewise, 1089 (61.9%) of report and requisition form reports data were accurate ranged from 31 to 100% that 49 (89%) were complete and 51 (92.7%) were timely reported with health facilities reporting rate of 55 (91.7%). Poor facility setup and lack of organizational supports identified as principal bottlenecks of logistics management information system performance. Conclusion: The data accuracy of bin card records and report and requisition form reports were under an ideal condition while others were promising. The average data accuracy of bin card records of anti-malaria drugs was the highest with the lowest accurate report, and there is a need for improvement in data quality, organizational support, and facility setups.

Introduction. Traditional medicinal plants are used as a common source of developing new and effective antimalarial drugs. E. globulus leaf has been used in the traditional management of malaria in different countries, including Ethiopia. However, there is no in vivo study done on the antimalarial activity of the plant. Thus, this study aimed to evaluate the antimalarial activity of crude extract of E. globulus Labill. leaf in P. berghei-infected mice. Method. The fresh leaves of E. globulus were collected, washed, air-dried, and made as coarse powder. Either sex of mice aged 6 to 8 weeks was used in the experiment. The antimalarial activity of the crude extract was tested in four-day suppressive, curative (Rane’s), and prophylactic (repository) tests. The parameters like level of parasitemia, packed cell volume, body weight, rectal temperature, and mean survival time were recorded. The analysis of the data was done with SPSS version 20 with a 95% confidence interval in one-way ANOVA followed by Tukey’s post hoc test. Results. In all three antimalarial test models, the extract of leaf of E. globulus at all three doses suppressed the level of parasitemia significantly ( ), increased survival time ( to ), and prevented a decrease in body weight as compared to the negative control. The middle and large doses of the extract also decreased loss of body temperature ( to ) compared to the negative control. Reduction of packed cell volume was prevented within the three test doses of the extract in both curative and prophylactic tests and middle and large doses in the 4-day suppressive test compared to the negative control. Conclusion. The crude extract of the plant showed promising antimalarial activity. This supports the traditional use and the in vitro test result of the plant.

Introduction: Surgical safety checklist is used for every patient undergoing a surgical procedure and is now employed by a majority of surgical providers around the world, but the utilization and completion of surgical safety checklists were low in lower- and middle-income countries. Objective: The objective of this study was to evaluate the utilization and completeness of the surgical safety checklist in surgical units of Jimma University Medical Center, Ethiopia. Methods: Hospital-based prospective cross-sectional study was conducted from October 1 to 30, 2020. A total of 384 surgical cases were included in the study. Checklists were kept as part of each patient’s medical record, and consecutive post-operative patient charts were included in the study. The data were collected using the modified version of the WHO checklist constituted of 27 items. The collected data were cleaned, coded, and entered into EpiData version 3.1 and exported to SPSS version 20 for analysis. Binary and multiple logistic regression analyses were computed, and the level of statistical significance was determined at p < 0.05. Results: The use of a surgical safety checklist was 93.5%. The checklist was completed 17.3% of the time, with sign-in, time-out, and sign-out being completed 83%, 25%, and 35% of the time, respectively. Utilization of the surgical safety checklist was 87.4%, which is lower in elective surgeries (AOR = 0.126 95% CI (0.039– 0.414)) compared with the emergency procedure. Once more, the completeness of the safety checklist was 63.3%, which is lower in elective surgery (AOR = 0.367 95% CI (0.208– 0.65)) than in emergency procedures. Conclusion: The use of a surgical safety checklist was promising, while the completeness of the checklist was poor that demands further improvement. Time-out was the least completed section of the checklist. Completion of the checklist was high in the first case on the positions of the theatre list.

Background: Integrated Pharmaceutical Logistics System is the primary mechanism through which all public health facilities in Ethiopia get essential pharmaceutical products from their main supplier. Pharmaceuticals should be managed appropriately because they are part of the link between the patient and health services and account for up to half of the healthcare budget. This study aimed to assess the status of Integrated Pharmaceutical Logistics System implementation at both Chagni Primary Hospital and Injibara General Hospital. Methods: Facility-based descriptive study design supported with a qualitative study design was used. Face-to-face interviews, observation of practices, and document review were conducted to gather quantitative data. Besides, the qualitative data were collected through in-depth face-to-face interviews. Frequency and percentage were computed, and the results were briefly described in text and displayed in tables and graphs. The qualitative data were transcribed manually, and thematic analysis was done. Results: All IPLS materials were available in both hospitals, but the stock recording card was not available at Injibara General Hospital. About 90% and 100% of the dispensing units in Chagni Primary Hospital and Injibara general hospital were utilizing bin-cards, respectively. Besides, 50% and 80% of the bin-cards in Chagrin Primary Hospital and Injibara General Hospital were regularly updated, respectively. About 80% and 75% of the IFRRs in Chagni Primary Hospital and Injibara General Hospital reported valid data, respectively. Besides, 66.67% and 50% of the RRFs reviewed at Chagni Primary Hospital and Injibara General Hospital reported valid data, respectively. Medicine stockouts, poor staff commitment, and workload were the major bottlenecks for IPLS execution. Conclusion: The status of most of the IPLS implementation indicators in both hospitals was good. Especially, the availabilities of IPLS materials and the calculation accuracy of both RRFs and IFRRs were encouraging in both hospitals. However, the validity of the data reported in IFRRs and RRFs, and the status of the storage conditions in both hospitals need some improvement during the implementations of IPLS.

Medicines are kept unused at home for many therapeutic reasons. Conversely, unused medication and subsequent wastage can be attributed to several primary factors such as medication change, death, and non-adherence. This study aimed to assess the magnitude and associated factors of unused medication storage practice among households in Jimma City, southwest Ethiopia. A community-based cross-sectional study design was conducted among households (n = 397) in Jimma Town from July to August 2021. The data were collected using the pre-tested and interviewer-administered questionnaire. SPSS version 21.0 was used for data analysis. The multivariate logistic regression was used to determine the factors associated with the storage of unused medicine at a 5% level of significance. Out of 397 households that responded, (n = 90, 23%) of households were found to have unused medicine at home. This study showed that the majority of households dispose of unused drugs by burning them (32.2%) and burying them in the ground (29%). Antibiotics were the most (6.3%) unused medicines stored while the anti-diabetics (1.3%) were the least unused drugs stored among households. The presence of family members working in the health sector (AOR: 0.402, 95%, CI: 0.202, 0.800) and family size in households (AOR: 2.325, 95%, CI: 1.045, 5.174) were significantly associated with the magnitude of unused medicine storage. The magnitude and improper disposal of unused medicines storage among households were significant in the study area. Therefore, it is important to educate the community and encourage health professionals to understand their role in problems and solutions.