YOLO has become a central real-time object detection system for robotics, driverless cars, and video monitoring applications. We present a comprehensive analysis of YOLO’s evolution, examining the innovations and contributions in each iteration from the original YOLO up to YOLOv8, YOLO-NAS, and YOLO with transformers. We start by describing the standard metrics and postprocessing; then, we discuss the major changes in network architecture and training tricks for each model. Finally, we summarize the essential lessons from YOLO’s development and provide a perspective on its future, highlighting potential research directions to enhance real-time object detection systems.

This paper presents a comprehensive review of loss functions and performance metrics in deep learning, highlighting key developments and practical insights across diverse application areas. We begin by outlining fundamental considerations in classic tasks such as regression and classification, then extend our analysis to specialized domains like computer vision and natural language processing including retrieval-augmented generation. In each setting, we systematically examine how different loss functions and evaluation metrics can be paired to address task-specific challenges such as class imbalance, outliers, and sequence-level optimization. Key contributions of this work include: (1) a unified framework for understanding how losses and metrics align with different learning objectives, (2) an in-depth discussion of multi-loss setups that balance competing goals, and (3) new insights into specialized metrics used to evaluate modern applications like retrieval-augmented generation, where faithfulness and context relevance are pivotal. Along the way, we highlight best practices for selecting or combining losses and metrics based on empirical behaviors and domain constraints. Finally, we identify open problems and promising directions, including the automation of loss-function search and the development of robust, interpretable evaluation measures for increasingly complex deep learning tasks. Our review aims to equip researchers and practitioners with clearer guidance in designing effective training pipelines and reliable model assessments for a wide spectrum of real-world applications.

Recent advances in large language models (LLMs) have triggered rapid growth in AI-powered educational agents, yet researchers and practitioners still lack a consolidated view of how these systems are engineered and validated. To address this gap, we conducted a systematic literature review of 82 peer-reviewed and industry studies published from January 2023 to February 2025. Using a four-phase protocol, we extracted and coded them along six groups: technical and pedagogical frameworks, tutoring systems, assessment and feedback, curriculum design, personalization, and ethical considerations. Synthesizing these findings, we propose design principles that link technical choices to instructional goals and outline safeguards for privacy, fairness, and academic integrity. Across all domains, the evidence converges on a key insight: hybrid human–AI workflows, in which teachers curate and moderate LLM output, outperform fully autonomous tutors by combining scalable automation with pedagogical expertise. Limitations in the current literature, including short study horizons, small-sample experiments, and a bias toward positive findings, temper the generalizability of reported gains, highlighting the need for rigorous, long-term evaluations.

Digital transformation is reshaping the healthcare field by streamlining diagnostic workflows and improving disease management. Within this transformation, Digital Twins (DTs), which are virtual representations of physical systems continuously updated by real-world data, stand out for their ability to capture the complexity of human physiology and behavior. When coupled with Artificial Intelligence (AI), DTs enable data-driven experimentation, precise diagnostic support, and predictive modeling without posing direct risks to patients. However, their integration into healthcare requires careful consideration of ethical, regulatory, and safety constraints in light of the sensitivity and nonlinear nature of human data. In this review, we examine recent progress in DTs over the past seven years and explore broader trends in AI-augmented DTs, focusing particularly on movement rehabilitation. Our goal is to provide a comprehensive understanding of how DTs bolstered by AI can transform healthcare delivery, medical research, and personalized care. We discuss implementation challenges such as data privacy, clinical validation, and scalability along with opportunities for more efficient, safe, and patient-centered healthcare systems. By addressing these issues, this review highlights key insights and directions for future research to guide the proactive and ethical adoption of DTs in healthcare.

Automatic sign language recognition is a challenging task in machine learning and computer vision. Most works have focused on recognizing sign language using hand gestures only. However, body motion and facial gestures play an essential role in sign language interaction. Taking this into account, we introduce an automatic sign language recognition system based on multiple gestures, including hands, body, and face. We used a depth camera (OAK-D) to obtain the 3D coordinates of the motions and recurrent neural networks for classification. We compare multiple model architectures based on recurrent networks such as Long Short-Term Memories (LSTM) and Gated Recurrent Units (GRU) and develop a noise-robust approach. For this work, we collected a dataset of 3000 samples from 30 different signs of the Mexican Sign Language (MSL) containing features coordinates from the face, body, and hands in 3D spatial coordinates. After extensive evaluation and ablation studies, our best model obtained an accuracy of 97% on clean test data and 90% on highly noisy data.