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Sriraman Devarajan
National Dasman Diabetes Biobank, Special Services Facility, Dasman Diabetes Institute, Dasman 15462, Kuwait

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Journal article
Published: 04 June 2021 in Microorganisms
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The potential role of the salivary microbiome in human diseases has increasingly been explored. The salivary microbiome has been characterized in several global populations, except the Arabian Gulf region. Hence, in this pilot study, we profiled the salivary microbiome of Kuwaiti adolescents with varied body mass indexes (BMI). The analyses of core microbiome composition showed Firmicutes, Bacteroidota, Proteobacteria, Patescibacteria, Fusobacteriota, Actinobacteriota, and Campylobacterota as the common phylum found in the Kuwaiti adolescent population. We also illustrated a diverse microbial community among the sampled individuals grouped according to their BMI. Notably, the overweight group was found with a higher number of distinct taxa than other groups. As such, the core microbiome composition was found to be significantly different (p-value < 0.001) across different BMI groups. Overall, this pilot investigation outlined the microbial diversity and suggested that changes in salivary microbiome composition in people with obese or overweight BMI might reflect their susceptibility to oral diseases.

ACS Style

Hend Alqaderi; Meganathan Ramakodi; Rasheeba Nizam; Sindhu Jacob; Sriraman Devarajan; Muthukrishnan Eaaswarkhanth; Fahd Al-Mulla. Salivary Microbiome Diversity in Kuwaiti Adolescents with Varied Body Mass Index—A Pilot Study. Microorganisms 2021, 9, 1222 .

AMA Style

Hend Alqaderi, Meganathan Ramakodi, Rasheeba Nizam, Sindhu Jacob, Sriraman Devarajan, Muthukrishnan Eaaswarkhanth, Fahd Al-Mulla. Salivary Microbiome Diversity in Kuwaiti Adolescents with Varied Body Mass Index—A Pilot Study. Microorganisms. 2021; 9 (6):1222.

Chicago/Turabian Style

Hend Alqaderi; Meganathan Ramakodi; Rasheeba Nizam; Sindhu Jacob; Sriraman Devarajan; Muthukrishnan Eaaswarkhanth; Fahd Al-Mulla. 2021. "Salivary Microbiome Diversity in Kuwaiti Adolescents with Varied Body Mass Index—A Pilot Study." Microorganisms 9, no. 6: 1222.

Journal article
Published: 25 October 2020 in Journal of Clinical Medicine
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Background: This study aimed to estimate the prevalence of diabetes and prediabetes in adults in Kuwait. Methods: The Kuwait Diabetes Epidemiology Program was a nationally representative, cross-sectional study of diabetes and obesity in Kuwait conducted between 2011 and 2014. The survey sampled 4937 adults in Kuwait aged 20 years or more and recorded participants’ demographics, behaviours, medical history, physical measurements and blood biochemical measurements. Prediabetes was defined as fasting plasma glucose between 6.1 and 6.9 mmol/L or HbA1c between 6 and 6.4% (42–47 mmol/mol). Diabetes was defined as self-reported history with prescribed glucose-lowering medication or FPG ≥7mmol/L or HbA1c level ≥6.5% (≥48 mmol/mol). Results: The overall adjusted prevalence of diabetes was 19.1%. The overall adjusted prevalence of prediabetes was 13.5%. Diabetes prevalence was 5.4%, 14.2%, 38.7% and 64.8% in adults aged 20–29, 30–44, 45–59 and 60 years or more, respectively. Diabetes prevalence was 22.4% in men and 14.4% in women. Prediabetes prevalence was 14.8% in men and 11.5% in women. In Kuwaitis, diabetes and prediabetes prevalence was 21.8% and 11.1%, respectively, while prevalence in non-Kuwaitis was 18.2% for diabetes and 14.3% for prediabetes. Conclusion: These findings illustrate the severe public health challenge posed by diabetes in Kuwait.

ACS Style

Abdullah Alkandari; Monira Alarouj; Naser Elkum; Prem Sharma; Sriraman Devarajan; Mohamed Abu-Farha; Fahd Al-Mulla; Jaakko Tuomilehto; Abdullah Bennakhi. Adult Diabetes and Prediabetes Prevalence in Kuwait: Data from the Cross-Sectional Kuwait Diabetes Epidemiology Program. Journal of Clinical Medicine 2020, 9, 3420 .

AMA Style

Abdullah Alkandari, Monira Alarouj, Naser Elkum, Prem Sharma, Sriraman Devarajan, Mohamed Abu-Farha, Fahd Al-Mulla, Jaakko Tuomilehto, Abdullah Bennakhi. Adult Diabetes and Prediabetes Prevalence in Kuwait: Data from the Cross-Sectional Kuwait Diabetes Epidemiology Program. Journal of Clinical Medicine. 2020; 9 (11):3420.

Chicago/Turabian Style

Abdullah Alkandari; Monira Alarouj; Naser Elkum; Prem Sharma; Sriraman Devarajan; Mohamed Abu-Farha; Fahd Al-Mulla; Jaakko Tuomilehto; Abdullah Bennakhi. 2020. "Adult Diabetes and Prediabetes Prevalence in Kuwait: Data from the Cross-Sectional Kuwait Diabetes Epidemiology Program." Journal of Clinical Medicine 9, no. 11: 3420.

Journal article
Published: 01 September 2020 in Metabolites
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Background: Obstructive sleep apnea (OSA) is caused by partial or complete obstruction of the upper airways. Corrective surgeries aim at removing obstructions in the nasopharynx, oropharynx, and hypopharynx. OSA is associated with an increased risk of various metabolic diseases. Our objective was to evaluate the effect of surgery on the plasma metabolome. Methods: This study included 39 OSA patients who underwent Multilevel Sleep Surgery (MLS). Clinical and anthropometric measures were taken at baseline and five months after surgery. Results: The mean Apnea-Hypopnea Index (AHI) significantly dropped from 22.0 ± 18.5 events/hour to 8.97 ± 9.57 events/hour (p-Value < 0.001). Epworth’s sleepiness Score (ESS) dropped from 12.8 ± 6.23 to 2.95 ± 2.40 (p-Value < 0.001), indicating the success of the surgery in treating OSA. Plasma levels of metabolites, phosphocholines (PC) PC.41.5, PC.42.3, ceremide (Cer) Cer.44.0, and triglyceride (TG) TG.53.6, TG.55.6 and TG.56.8 were decreased (p-Value < 0.05), whereas lysophosphatidylcholines (LPC) 20.0 and PC.39.3 were increased (p-Value < 0.05) after surgery. Conclusion: This study highlights the success of MLS in treating OSA. Treatment of OSA resulted in an improvement of the metabolic status that was characterized by decreased TG, PCs, and Cer metabolites after surgery, indicating that the success of the surgery positively impacted the metabolic status of these patients.

ACS Style

Abdulmohsen AlTerki; Shibu Joseph; Thangavel Alphonse Thanaraj; Irina Al-Khairi; Preethi Cherian; Arshad Channanath; Devarajan Sriraman; Mahmoud A. K. Ebrahim; Alaaeldin Ibrahim; Ali Tiss; Fahd Al-Mulla; Anas M. Abdel Rahman; Jehad Abubaker; Mohamed Abu-Farha. Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery. Metabolites 2020, 10, 358 .

AMA Style

Abdulmohsen AlTerki, Shibu Joseph, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Devarajan Sriraman, Mahmoud A. K. Ebrahim, Alaaeldin Ibrahim, Ali Tiss, Fahd Al-Mulla, Anas M. Abdel Rahman, Jehad Abubaker, Mohamed Abu-Farha. Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery. Metabolites. 2020; 10 (9):358.

Chicago/Turabian Style

Abdulmohsen AlTerki; Shibu Joseph; Thangavel Alphonse Thanaraj; Irina Al-Khairi; Preethi Cherian; Arshad Channanath; Devarajan Sriraman; Mahmoud A. K. Ebrahim; Alaaeldin Ibrahim; Ali Tiss; Fahd Al-Mulla; Anas M. Abdel Rahman; Jehad Abubaker; Mohamed Abu-Farha. 2020. "Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery." Metabolites 10, no. 9: 358.

Other
Published: 22 August 2020
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Background COVID-19 has a highly variable clinical presentation, ranging from asymptomatic to severe respiratory symptoms and death. Diabetes seems to be one of the main comorbidities contributing to a worse COVID-19 outcome. Objective In here we analyze the clinical characteristics and outcomes of diabetic COVID-19 patients Kuwait. Methods In this single-center, retrospective study of 417 consecutive COVID-19 patients, we analyze and compare disease severity, outcome, associated complications, and clinical laboratory findings between diabetic and non-diabetic COVID-19 patients. Results COVID-19 patients with diabetes had more ICU admission than non-diabetic COVID-19 patients (20.1% vs. 16.8%, p<0.001). Diabetic COVID-19 patients also recorded higher mortality in comparison to non-diabetic COVID-19 patients (16.7% vs. 12.1%, p<0.001). Diabetic COVID-19 patients had significantly higher prevalence of comorbidities, such as hypertension. Laboratory investigations also highlighted notably higher levels of C-reactive protein in diabetic COVID019 patients and lower estimated glomerular filtration rate. They also showed a higher incidence of complications. logistic regression analysis showed that every 1 mmol/L increase in fasting blood glucose in COVID-19 patients is associated with 1.52 (95% CI: 1.34 – 1.72, p<0.001) times the odds of dying from COVID-19. Conclusion Diabetes is a major contributor to worsening outcomes in COVID-19 patients. Understanding the pathophysiology underlining these findings could provide insight into better management and improved outcome of such cases. Highlights of the Study A significantly higher proportion of COVID-19 patients with diabetes mellitus required admission to the ICU. Higher fasting blood glucose was associated with higher risk of COVID-19 associated mortality. COVID-19 patients with diabetes mellitus had significantly higher incidence of complications including sepsis, ARDS, cardiac failure and renal failure.

ACS Style

Abdullah Alshukry; Mohammad Bu Abbas; Yaseen Ali; Barrak Alahmad; Abdullah A. Al-Shammari; Ghadeer Alhamar; Mohammad Abu-Farha; Jehad AbuBaker; Sriraman Devarajan; Ali A. Dashti; Fahd Al-Mulla; Hamad Ali. Clinical Characteristics and Outcomes of COVID-19 patients with diabetes mellitus in Kuwait. 2020, 1 .

AMA Style

Abdullah Alshukry, Mohammad Bu Abbas, Yaseen Ali, Barrak Alahmad, Abdullah A. Al-Shammari, Ghadeer Alhamar, Mohammad Abu-Farha, Jehad AbuBaker, Sriraman Devarajan, Ali A. Dashti, Fahd Al-Mulla, Hamad Ali. Clinical Characteristics and Outcomes of COVID-19 patients with diabetes mellitus in Kuwait. . 2020; ():1.

Chicago/Turabian Style

Abdullah Alshukry; Mohammad Bu Abbas; Yaseen Ali; Barrak Alahmad; Abdullah A. Al-Shammari; Ghadeer Alhamar; Mohammad Abu-Farha; Jehad AbuBaker; Sriraman Devarajan; Ali A. Dashti; Fahd Al-Mulla; Hamad Ali. 2020. "Clinical Characteristics and Outcomes of COVID-19 patients with diabetes mellitus in Kuwait." , no. : 1.

Preprint
Published: 15 July 2020
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Background: Obstructive sleep apnea (OSA) is caused by partial or complete obstruction of the upper airways. Corrective surgeries aim at removing obstructions in the nasopharynx, oropharynx, and hypopharynx. OSA is associated with increased risk of various metabolic diseases. Our objective was to evaluate the effect of surgery on the plasma metabolome. Methods: This study included 39 OSA patients who underwent Multilevel Sleep Surgery (MLS). Clinical and anthropometric measures were taken at baseline and 5 months after surgery. Results: The mean Apnea Hypopnea Index (AHI) significantly dropped from 22.0 ± 18.5 events/hour to 8.97 ± 9.57 events/hour (p-Value <0.001). The Epworth’s sleepiness Score (ESS) dropped from 12.8 ± 6.23 to 2.95 ± 2.40 (p-Value <0.001) indicating success of the surgery in treating OSA. Plasma levels of metabolites, phosphocholines (PC) PC.41.5, PC.42.3, ceremide (Cer) Cer.44.0, and triglyceride (TG) TG.53.6, TG.55.6 and TG.56.8 were decreased (p-Value<0.05) whereas lysophosphatidylcholines (LPC) 20.0 and PC.39.3 were increased (p-Value<0.05) after surgery. Conclusion: This study highlights the success of MLS in treating OSA. Treatment of OSA resulted in improvement in metabolic status that was characterized by decreased TG, PCs and Cer metabolites post-surgery indicating that the success of the surgery positively impacted the metabolic status of these patients.

ACS Style

Abdulmohsen AlTerki; Shibu Joseph; Thangavel Alphonse Thanaraj; Irina Al-Khairi; Preethi Cherian; Arshad Channanath; Devarajan Sriraman; Mahmoud Ebrahim; Alaaeldin Ibrahim; Ali Tiss; Fahd Al-Mulla; Jehad Abubaker; Mohamed Abu-Farha. Analysis of Metabolites Changes on Obstructive Sleep Apnea Patients After Multilevel Sleep Surgery. 2020, 1 .

AMA Style

Abdulmohsen AlTerki, Shibu Joseph, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Devarajan Sriraman, Mahmoud Ebrahim, Alaaeldin Ibrahim, Ali Tiss, Fahd Al-Mulla, Jehad Abubaker, Mohamed Abu-Farha. Analysis of Metabolites Changes on Obstructive Sleep Apnea Patients After Multilevel Sleep Surgery. . 2020; ():1.

Chicago/Turabian Style

Abdulmohsen AlTerki; Shibu Joseph; Thangavel Alphonse Thanaraj; Irina Al-Khairi; Preethi Cherian; Arshad Channanath; Devarajan Sriraman; Mahmoud Ebrahim; Alaaeldin Ibrahim; Ali Tiss; Fahd Al-Mulla; Jehad Abubaker; Mohamed Abu-Farha. 2020. "Analysis of Metabolites Changes on Obstructive Sleep Apnea Patients After Multilevel Sleep Surgery." , no. : 1.

Other
Published: 16 June 2020
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This is a retrospective single-center study of 417 consecutive patients with coronavirus disease 2019 (COVID-19) admitted to Jaber Al-Ahmad Hospital in Kuwait between February 24, 2020 and May 24, 2020. In total, 39.3% of patients were asymptomatic, 41% were symptomatic with mild/moderate symptoms, 5.3% were admitted to the intensive care unit (ICU) and recovered, and 14.4% died. The mean age of death cases was 54.20 years (± 11.09). Comorbidities were more prevalent in patients who died compared with others. Key findings include abnormal levels of markers assicated with infection, inflammation, abnormal blood clotting, heart problems and kidney problems in patients with severe form of the disease and poor putcome. We report a rapidly deteriorating estimated glomerular filtration rate (eGFR) in deaths during ICU stay with kidney injury complications reported in 65% of deaths (p < 0.05). Our dynamic profiling of eGFR in ICU highlights the potential role of renal markers in forecasting disease outcome that could perhaps identify patients at risk of poor outcome.

ACS Style

Abdullah Alshukry; Hamad Ali; Yaseen Ali; Talal Al Taweel; Mohammad Abu-Farha; Jehad Abubaker; Sriraman Devarajan; Ali A. Dashti; Ali Bandar; Hessah Taleb; Abdullah Al Bader; Nasser Y. Aly; Ebaa Al-Ozairi; Fahd Al-Mulla; Mohammad Bu Abbas. Clinical characteristics of Coronavirus Disease 2019 (COVID-19) patients in Kuwait. 2020, 1 .

AMA Style

Abdullah Alshukry, Hamad Ali, Yaseen Ali, Talal Al Taweel, Mohammad Abu-Farha, Jehad Abubaker, Sriraman Devarajan, Ali A. Dashti, Ali Bandar, Hessah Taleb, Abdullah Al Bader, Nasser Y. Aly, Ebaa Al-Ozairi, Fahd Al-Mulla, Mohammad Bu Abbas. Clinical characteristics of Coronavirus Disease 2019 (COVID-19) patients in Kuwait. . 2020; ():1.

Chicago/Turabian Style

Abdullah Alshukry; Hamad Ali; Yaseen Ali; Talal Al Taweel; Mohammad Abu-Farha; Jehad Abubaker; Sriraman Devarajan; Ali A. Dashti; Ali Bandar; Hessah Taleb; Abdullah Al Bader; Nasser Y. Aly; Ebaa Al-Ozairi; Fahd Al-Mulla; Mohammad Bu Abbas. 2020. "Clinical characteristics of Coronavirus Disease 2019 (COVID-19) patients in Kuwait." , no. : 1.

Journal article
Published: 22 December 2018 in Lipids in Health and Disease
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The hepatokine fetuin-A is linked to obesity and type 2 diabetes, but its presence and expression in adipose tissue remain unclear. In this study, we aimed to assess the circulating levels of fetuin-A and its expression in subcutaneous adipose tissue (SAT) from diabetic and non-diabetic obese subjects and their modulation by exercise. SAT and blood were obtained from adults obese (diabetic, n=118 and non-diabetic, n=166) before and after a 3-month exercise program (diabetic, n=40 and non-diabetic, n=36, respectively). Plasma fetuin-A was assayed using ELISA. The presence and expression of fetuin-A in SAT, peripheral blood mononuclear cells (PBMCs) and cell lines (3T3-L1, THP-1, HepG2, RAW 264.7) were analysed using confocal microscopy, immunoblotting and qRT-PCR. Plasma fetuin-A level did not significantly differ between diabetic and non-diabetic obese subjects. However, when the non-diabetic group was divided into metabolically healthy and unhealthy phenotypes, significantly higher fetuin-A level was observed in the unhealthy sub-group. Circulating fetuin-A was mainly associated with glycaemic markers. In SAT, fetuin-A protein level was significantly higher in the diabetic obese subjects but its mRNA was not detected. Similarly, fetuin-A protein was detected in PBMCs, but its mRNA was not. In line with this, the use of various cell lines and culture media indicated that the presence of fetuin-A in SAT and PBMCs was due to its uptake from circulation rather than its endogenous expression. Finally, physical exercise decreased fetuin-A levels in both plasma and SAT in both groups. Fetuin-A levels increased in association with diabetes in SAT but not in circulation in the obese subjects. Moreover, physical exercise decreased fetuin-A level. Fetuin-A potentially acts as a hepatokine taken up by other tissues, such as adipose tissue.

ACS Style

Abdelkrim Khadir; Sina Kavalakatt; Dhanya Madhu; Maha Hammad; Sriraman Devarajan; Jaakko Tuomilehto; Ali Tiss. Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation. Lipids in Health and Disease 2018, 17, 291 .

AMA Style

Abdelkrim Khadir, Sina Kavalakatt, Dhanya Madhu, Maha Hammad, Sriraman Devarajan, Jaakko Tuomilehto, Ali Tiss. Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation. Lipids in Health and Disease. 2018; 17 (1):291.

Chicago/Turabian Style

Abdelkrim Khadir; Sina Kavalakatt; Dhanya Madhu; Maha Hammad; Sriraman Devarajan; Jaakko Tuomilehto; Ali Tiss. 2018. "Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation." Lipids in Health and Disease 17, no. 1: 291.

Journal article
Published: 01 March 2018 in Lipids in Health and Disease
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Hypertension is a risk factor for both cardiovascular diseases (CVDs) and type 2 diabetes (T2D). Angiopoietin-like proteins (ANGPTLs), mainly ANGPTL3, ANGPTL4 and ANGPTL8, are associated with increased plasma lipid content due to their role in regulating the activity of lipoprotein lipase, a key enzyme in metabolism of the lipoprotein in circulation. Dyslipidaemia is a risk factor for hypertension development; however, the roles of ANGPTL3, ANGPTL4 and ANGPTL8 in subjects with hypertension have not yet been established. This study compared the plasma and adipose tissue levels of ANGPTL3, ANGPTL4 and ANGPTL8 in age- and body mass index-matched subjects with and without hypertension. A total of 119 subjects, including 69 hypertensive and 50 non-hypertensive subjects, were enrolled. ANGPTL3, ANGPTL4 and ANGPTL8 plasma levels were measured by ELISA, whereas their levels in adipose tissue were assessed via real-time PCR. We found that ANGPTL4 (202.49 ± 17.44 ng/mL vs. 160.64 ± 10.36 ng/mL, p = 0.04) and ANGPTL8 levels (2310.96 ± 194.88 pg/mL vs. 1583.35 ± 138.27 pg/mL, p = 0.001) were higher in hypertensive subjects than non-hypertensive subjects. However, ANGPTL3 levels were not significantly different between the two populations. Similarly, ANGPTL4 and ANGPTL8 levels were also elevated in subjects with T2D and hypertension than in those with T2D but not hypertension. Additionally, people with highest tertiles of ANGPTL8 had higher odds of having hypertension (odd ratio [OR] = 3.8, 95% confidence interval [CI] = (1.5-9.8), p-Value = 0.005. Similar to its plasma levels, ANGPTL4 and ANGPTL8 were higher in adipose tissue. In conclusion, our data illustrate that ANGPTL4 and ANGPTL8 levels in both plasma and adipose tissues are increased in subjects with hypertension. The elevated levels of ANGPTL4 and ANGPTL8 in hypertensive subjects highlight their potential involvement, their potential role as biomarkers for hypertension and their therapeutic value in hypertension given their roles in regulating lipid metabolism.

ACS Style

Mohamed Abu-Farha; Preethi Cherian; Mohamed G. Qaddoumi; Irina AlKhairi; Devarajan Sriraman; Muath Alanbaei; Jehad Abubaker. Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension. Lipids in Health and Disease 2018, 17, 1 -9.

AMA Style

Mohamed Abu-Farha, Preethi Cherian, Mohamed G. Qaddoumi, Irina AlKhairi, Devarajan Sriraman, Muath Alanbaei, Jehad Abubaker. Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension. Lipids in Health and Disease. 2018; 17 (1):1-9.

Chicago/Turabian Style

Mohamed Abu-Farha; Preethi Cherian; Mohamed G. Qaddoumi; Irina AlKhairi; Devarajan Sriraman; Muath Alanbaei; Jehad Abubaker. 2018. "Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension." Lipids in Health and Disease 17, no. 1: 1-9.

Journal article
Published: 13 October 2016 in Lipids in Health and Disease
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Hypertriglyceridemia is associated with increased risk for cardiovascular diseases and type 2 diabetes (T2D). Angiopoietin like proteins particularly 3, 4 and recently 8 are well established regulators of plasma triglyceride level through regulating the activity of lipoprotein lipase. Plasma level and association between ANGPTL3, 4 and 8 is not well established in human subjects. This study was designed to establish the level of these proteins in plasma and adipose tissues and investigate the association between ANGPTL8 with ANGPTL3 and 4 in T2D and non-diabetics subjects. A total of 235 subjects were enrolled in this study, 144 non-diabetics and 91 T2D. ANGPTL 3, 4 and 8 levels were measured in plasma by ELISA and using real time RT-PCR in adipose tissues. In this study, we showed that ANGPTL3, 4 and 8 were higher in T2D subjects. Dividing the non-diabetic subjects according to their BMI showed higher level of ANGPTL3, 4 and 8 in obese subjects compared to non-obese subjects. No significant difference was observed between the T2D subjects. ANGPTL8 was showed positive correlation with ANGPTL3 in the non-diabetic subjects in the non-obese (r = 0.2437, p-Value = 0.0543) and obese subjects (r = 0.418, p-Value = 0.0125). No association was observed in the T2D subjects. On the other hand, ANGPTL4 was positively associated with the obese subjects in both the non-diabetics (r = 0.3322, p-Value = 0.0316) and the obese T2D subjects (r = 0.3161, p-Value = 0.0211). In conclusion, our data shows that ANGPTL3, 4 and 8 are increased in obesity and T2D. ANGPTL8 associates with ANGPTL3 in the non-diabetic subjects while it associated more with ANGPTL4 in the obese and T2D subjects. Taken together, this data highlight the role of these proteins in metabolic diseases and how they interact with each other’s under different physiological and pathophysiological conditions.

ACS Style

Mohamed Abu-Farha; Irina Al-Khairi; Preethi Cherian; Betty Chandy; Devarajan Sriraman; Asma Alhubail; Faisal Al-Refaei; Abdulmohsen AlTerki; Jehad Abubaker. Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D. Lipids in Health and Disease 2016, 15, 181 .

AMA Style

Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Betty Chandy, Devarajan Sriraman, Asma Alhubail, Faisal Al-Refaei, Abdulmohsen AlTerki, Jehad Abubaker. Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D. Lipids in Health and Disease. 2016; 15 (1):181.

Chicago/Turabian Style

Mohamed Abu-Farha; Irina Al-Khairi; Preethi Cherian; Betty Chandy; Devarajan Sriraman; Asma Alhubail; Faisal Al-Refaei; Abdulmohsen AlTerki; Jehad Abubaker. 2016. "Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D." Lipids in Health and Disease 15, no. 1: 181.

Journal article
Published: 29 September 2016 in Journal of Diabetes & Metabolic Disorders
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Chronic inflammation is a hallmark of type-2 diabetes (T2D) and asthma. Monocyte chemoattractant protein (MCP)-1 or CCL-2 is a key regulator of monocytic infiltration into the sites of inflammation. The changes in systemic MCP-1 levels and its relationship with other inflammatory/immune markers in T2D patients with asthma remain unclear and have been addressed in this study. Plasma samples from 10 asthmatic T2D patients (Group I: BMI = 37.82 ± 9.75 kg/m2), 13 non-asthmatic T2D patients (Group II: BMI = 32.68 ± 4.63 kg/m2), 23 asthma patients without T2D (Group III: BMI = 30.14 ± 6.74 kg/m2), and 25 non-asthmatic non-diabetic controls (Group IV: BMI = 27.99 ± 5.86 kg/m2) were used to measure levels of MCP-1 and multiple cytokine/chemokine biomarkers with bead-based multiplex assays using Luminex technology. IgE/ECP were measured using commercial ELISA kits. Data (mean ± SEM) were compared using unpaired Student's t-test and linear dependence between two variables was assessed by Pearson's correlation coefficient (r) and P ≤ 0.05 was considered as significant. Plasma MCP-1 levels were significantly higher in Group I (337.95 ± 46.40 pg/mL) as compared with Group II (216.69 ± 17.30 pg/mL), Group III (251.76 ± 19.80 pg/mL), and Group IV (223.52 ± 133.36 pg/mL). MCP-1 showed differential association with tested biomarkers by correlating positively with: (i) IFN-α2, IL-10, fractalkine, and VEGF in T2D patients with asthma; (ii) IL-6 and GRO-α in T2D patients without asthma; (iii) MDC, IP-10, GM-CSF, FGF-2, and PDGF-AA/BB in patients with asthma only; and (iv) FPG and TG in non-asthmatic non-diabetic controls. MCP-1 associated with IL-1RA only in subjects with asthma. The systemic MCP-1 levels were significantly elevated in T2D patients with asthma as compared with those without asthma and/or diabetes while these changes correlated differentially with important biomarkers of inflammation and airway remodeling.

ACS Style

Sardar Sindhu; Merin Koshy; Areej Abu Al-Roub; Nadeem Akhter; Saad Al Zanki; Shamsha Ali; Sriraman Devarajan; Rasheed Ahmad. Differential association of plasma monocyte chemoattractant protein-1 with systemic inflammatory and airway remodeling biomarkers in type-2 diabetic patients with and without asthma. Journal of Diabetes & Metabolic Disorders 2016, 15, 40 .

AMA Style

Sardar Sindhu, Merin Koshy, Areej Abu Al-Roub, Nadeem Akhter, Saad Al Zanki, Shamsha Ali, Sriraman Devarajan, Rasheed Ahmad. Differential association of plasma monocyte chemoattractant protein-1 with systemic inflammatory and airway remodeling biomarkers in type-2 diabetic patients with and without asthma. Journal of Diabetes & Metabolic Disorders. 2016; 15 (1):40.

Chicago/Turabian Style

Sardar Sindhu; Merin Koshy; Areej Abu Al-Roub; Nadeem Akhter; Saad Al Zanki; Shamsha Ali; Sriraman Devarajan; Rasheed Ahmad. 2016. "Differential association of plasma monocyte chemoattractant protein-1 with systemic inflammatory and airway remodeling biomarkers in type-2 diabetic patients with and without asthma." Journal of Diabetes & Metabolic Disorders 15, no. 1: 40.