Context Dopamine agonist (DA)-induced impulse control disorder (ICD) in prolactinomas is not sufficiently known. Objective To evaluate the prevalence of DA-induced ICDs and possible risk factors related to these disorders in patients with prolactinoma. Design, Setting and Participants This is a cross-sectional multicenter study involving 308 prolactinoma patients followed-up in tertiary referral centers who received at least 3 months of DA therapy. DA-induced ICDs (pathological gambling, hypersexuality, compulsive shopping and compulsive eating) and impulsivity were assessed using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease (QUIP) and the Barratt Impulsiveness Scale-11 (BIS-11), respectively. Patients were evaluated in terms of parameters related with ICD development. Results Any ICD prevalence was 17% (n=51). Most common type was hypersexuality (6.5%). While any ICD and hypersexuality were more common in male patients (p=0.009, p<0.001, respectively), compulsive eating was more common in female patients (p=0.046). Current smoking, alcohol use and gambling history were more frequent (p=0.033, p=0.002, p=0.008, respectively) in patients with any ICD. In BIS-11 total, attentional, motor and non-planning scores were significantly higher in patients with any ICD (p<0.001). Current smoking and alcohol use were more frequent (p=0.007, p=0.003, respectively) and percentage increase of testosterone levels at last visit was higher (p=0.021) in male prolactinomas with hypersexuality. Conclusion Any ICD may be seen in one out of six with prolactinoma patients who are receiving DA therapy and endocrinology specialists should be aware of this significant side effect particularly in male patients with a history of gambling, smoking or alcohol use.

Diagnostic and Interventional Radiology

Aim. Fibrous dysplasia is a rare bone disease caused by missense mutation leading to abnormal fibroblast and osteoblast proliferation and increased bone resorption. FD can present in monostotic or polyostotic forms. About 3% of FD could be in association with McCune-Albright syndrome (MAS). Because FD is a rare disease, there is limited data in the literature about characteristics of disease and response to treatment.Methods. We present our five cases of FD with general properties and their responses to medical treatment.Results. Two of our patients had polyostotic and three had monostotic FD. One of the polyostotic patients had MAS. One of our patients had surgery for femur fractures, facial asymmetry, and findings of compression. Four patients were given pamidronate; one was given zoledronic acid as bisphosphonate treatment. Bone pain was relieved in all patients with medical treatment.Conclusion. There was a decrease in bone turnover markers to some degree with medical treatment but no radiological improvement was observed.