Zinc (Zn), one of the promising candidates for biodegradable implant materials, has excellent biocompatibility and biodegradability. In this study, as-cast Zn1FexMg (x ≤ 1.5 wt %) alloys were prepared to systematically explore the effects of magnesium (Mg) alloying on their microstructures, mechanical properties, and biodegradability. The microstructure of Zn1FexMg alloy consisted of Zn matrix, Zn + Mg₂Zn₁₁ eutectic structure, and FeZn₁₃ phase. The addition of Mg not only promoted grain refinement of the alloy, but also improved its mechanical properties. The results of immersion tests showed that the addition of Mg accelerated microcell corrosion between different phases, and the modeling of the corrosion mechanism of alloys in simulated body fluid (SBF) solution was discussed to describe the interaction between different phases in the corrosion process. Zn1Fe1Mg possessed superior comprehensive mechanical properties and appropriate corrosion rate, and the values for hardness, tensile strength, yield strength, elongation, and corrosion rate were 105 HB, 157 MPa, 146 MPa, 2.3%, and 0.027 mm/a, respectively, thus revealing that Zn1Fe1Mg is a preferred candidate for biodegradable implant material.

The ‘plainification of materials’ has been conceptualized to promote the sustainable development of materials. This perspective, for the first time in the field of biomaterials, proposes and defines ‘plain metallic biomaterials (PMBs)’ with demonstrated research and application case studies of pure titanium with high strength and toughness, and biodegradable, fine-grained and high-purity magnesium. Then, after discussing the features, benefits and opportunities of PMBs, the challenges are analyzed from both technical and regulatory aspects. Regulatory perspectives on PMB-based medical devices are also provided for the benefit of future research, development and commercialization.