Cognitive therapy (CT)¹ is a common empirically supported intervention that addresses systematic negative thinking and is effective for 40% to 60% of patients with unipolar depression.² Knowing which patients are likely to benefit from CT could increase response rates and decrease costs by targeted referrals. However, biological predictors of CT outcome^3-6 have not been adopted clinically. This gap in translation may result from the lack of reliability and validity data for these measures or from the inability to overcome variability across scanners/laboratories. Herein we examined whether our previously observed association of CT outcome with pretreatment activity in the subgenual anterior cingulate cortex (sgACC)⁴ replicates in multiple new samples and scanners.