Dr. Guo-Yuan Zhu
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau 999078, China
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Academic Career Length
22Years (2005-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 August 2015 in Journal of Ethnopharmacology
Journal Article
WCWai-I Chik
Wai-I Chik
LZLin Zhu
Lin Zhu
LFLan-Lan Fan
Lan-Lan Fan
TYTao YI
Tao YIGuo-Yuan ZhuHCHubiao Chen
Hubiao Chen +6
1 January 2014 in BMC Biochemistry
Journal Article
TYTao YI
Tao YILFLanlan Fan
Lanlan FanHCHong-Li Chen
Hong-Li ChenGuo-Yuan ZhuHSHau-Man Suen
Hau-Man SuenHCHubiao Chen
Hubiao Chen +4
Dioscorea is a genus of flowering plants, and some Dioscorea species are known and used as a source for the steroidal sapogenin diosgenin. To screen potential resource from Dioscorea species and related medicinal plants for diosgenin extraction, a rapid method to compare the contents of diosgenin in various plants is crucial. An ultra-performance liquid chromatography (UPLC) coupled with diode array detection (DAD) and electrospray ionization mass spectrometry (ESI-MS) method was developed for identification and determination of diosgenin in various plants. A comprehensive validation of the developed method was conducted. Twenty-four batches of plant samples from four Dioscorea species, one Smilax species and two Heterosmilax species were analyzed by using the developed method. The present method presented good sensitivity, precision and accuracy. Diosgenin was found in three Dioscorea species and one Heterosmilax species, namely D. zingiberensis, D. septemloba, D. collettii and H. yunnanensis. The method is suitable for the screening of diosgenin resources from plants. D. zingiberensis is an important resource for diosgenin harvesting.
14 January 2011 in Chemical Communications
Journal Article
CLChung-Hang Leung
Chung-Hang LeungDCDaniel Shiu-Hin Chan
Daniel Shiu-Hin Chan
HYHui Yang
Hui Yang
RARuben Abagyan
Ruben Abagyan
SLSimon Ming-Yuen Lee
Simon Ming-Yuen Lee
Dik-Lung Ma +2
The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.
1 September 2006 in Biochemical Pharmacology
Journal Article
CWChi-Keung Wan
Chi-Keung Wan
Guo-Yuan ZhuXSXiao-Ling Shen
Xiao-Ling Shen
ACApurba Chattopadhyay
Apurba Chattopadhyay
SDSaibal Dey
Saibal Dey
WFWang-Fun Fong
Wang-Fun Fong
1 February 2007 in Phytomedicine
Journal Article
WFW.-F. Fong
W.-F. FongCWC. Wang
C. Wang
Guo-Yuan ZhuCLC.-H. Leung
C.-H. Leung
MYM.-S. Yang
M.-S. YangHCHon-Yeung Cheung
Hon-Yeung Cheung8 June 2018 in Journal of Natural Products
Journal Article
XLXin Liu
Xin Liu
JFJing Fu
Jing Fu
XYXiao-Jun Yao
Xiao-Jun Yao
JYJi Yang
Ji Yang
LLLiang Liu
Liang Liu
Guo-Yuan Zhu +3
About Me
Dr. Guo-Yuan Zhu, Associate Professor. Dr. Zhu achieved his M. Phil. degree at the Nanjing University of Chinese Medicine in 2002. He earned a Ph.D. degree from Hong Kong Baptist University in 2011. Dr. Zhu has been working as a junior pharmacist at the Second People’s Hospital of Wuyi County (Zhejiang province), Research Assistant at Shenzhen Jinshan Natural Phytomedicine Research Institute, Science Director at Shenzhen Applied R&D centers (Biotech and Health Center) of the City University Hong Kong, and Research Assistant at Hong Kong Baptist University from 1991 to 2011. After postdoctoral training in the School of Chinese Medicine, Hong Kong Baptist University, and the State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology from 2011 to 2014, he joined Macau University of Science and Technology as an assistant professor in May 2014. Dr. Zhu’s research fields include natural products chemistry and chemical biology. He mainly focused on the isolation and structure elucidation of bioactive natural products, and their biological effects and molecular mechanisms on anticancer, anti-inflammatory, and anti-neurodegenerative diseases.