Anna Niarakis

Prof. Dr. Anna Niarakis

GenHotel-Evry Laboratoire de recherche européen pour la polyarthrite rhumatoïde, UEVE, University of Paris-Saclay, Genopole
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orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 February 2011 in Biomaterials
Verified
Journal Article
Closed access
Spyridon MourtasSpyridon Mourtas
Spyridon Mourtas
MCMara Canovi
Mara Canovi
CZCristiano Zona
Cristiano Zona
DADario Aurilia
Dario Aurilia
Anna NiarakisAnna Niarakis
Anna Niarakis
Sophia G. AntimisiarisSophia G. Antimisiaris
Sophia G. Antimisiaris

20 May 2022 in npj Digital Medicine
Verified
Journal Article
Open access
PDF file
RLR. Laubenbacher
R. Laubenbacher
Anna NiarakisAnna Niarakis
Anna Niarakis
THT. Helikar
T. Helikar
GAGary An
Gary An
BSB. Shapiro
B. Shapiro
JGJ. A. Glazier
J. A. Glazier
Digital twins, customized simulation models pioneered in industry, are beginning to be deployed in medicine and healthcare, with some major successes, for instance in cardiovascular diagnostics and in insulin pump control. Personalized computational models are also assisting in applications ranging from drug development to treatment optimization. More advanced medical digital twins will be essential to making precision medicine a reality. Because the immune system plays an important role in such a wide range of diseases and health conditions, from fighting pathogens to autoimmune disorders, digital twins of the immune system will have an especially high impact. However, their development presents major challenges, stemming from the inherent complexity of the immune system and the difficulty of measuring many aspects of a patient’s immune state in vivo. This perspective outlines a roadmap for meeting these challenges and building a prototype of an immune digital twin. It is structured as a four-stage process that proceeds from a specification of a concrete use case to model constructions, personalization, and continued improvement.

1 October 2011 in Nanomedicine: Nanotechnology, Biology and Medicine
Verified
Journal Article
Closed access
MTMark Taylor
Mark Taylor
SMSusan Moore
Susan Moore
Spyridon MourtasSpyridon Mourtas
Spyridon Mourtas
Anna NiarakisAnna Niarakis
Anna Niarakis
FRFrancesca Re
Francesca Re
DADavid Allsop
David Allsop

5 May 2020 in Scientific Data
Verified
Journal Article
Open access
PDF file
MOMarek Ostaszewski
Marek Ostaszewski
AMAlexander Mazein
Alexander Mazein
MGMarc Gillespie
Marc Gillespie
IKInna Kuperstein
Inna Kuperstein
Anna NiarakisAnna Niarakis
Anna Niarakis
RSReinhard Schneider
Reinhard Schneider
Researchers around the world join forces to reconstruct the molecular processes of the virus-host interactions aiming to combat the cause of the ongoing pandemic.

30 November 2024 in npj Systems Biology and Applications
Verified
Journal Article
Open access
PDF file
Anna NiarakisAnna Niarakis
Anna Niarakis
RLReinhard Laubenbacher
Reinhard Laubenbacher
GAGary An
Gary An
Yaron IlanYaron Ilan
Yaron Ilan
JFJasmin Fisher
Jasmin Fisher
JGJames A. Glazier
James A. Glazier
Digital twins represent a key technology for precision health. Medical digital twins consist of computational models that represent the health state of individual patients over time, enabling optimal therapeutics and forecasting patient prognosis. Many health conditions involve the immune system, so it is crucial to include its key features when designing medical digital twins. The immune response is complex and varies across diseases and patients, and its modelling requires the collective expertise of the clinical, immunology, and computational modelling communities. This review outlines the initial progress on immune digital twins and the various initiatives to facilitate communication between interdisciplinary communities. We also outline the crucial aspects of an immune digital twin design and the prerequisites for its implementation in the clinic. We propose some initial use cases that could serve as “proof of concept” regarding the utility of immune digital technology, focusing on diseases with a very different immune response across spatial and temporal scales (minutes, days, months, years). Lastly, we discuss the use of digital twins in drug discovery and point out emerging challenges that the scientific community needs to collectively overcome to make immune digital twins a reality.

1 February 2011 in European Journal of Pharmaceutics and Biopharmaceutics
Verified
Journal Article
Closed access
EMEleni Markoutsa
Eleni Markoutsa
GPGeorgios Pampalakis
Georgios Pampalakis
Anna NiarakisAnna Niarakis
Anna Niarakis
IRIgnacio Romero
Ignacio Romero
BWBabette Weksler
Babette Weksler
Sophia G. AntimisiarisSophia G. Antimisiaris
Sophia G. Antimisiaris