Objetivo. Evaluar el impacto de un programa de intervención con un suplemento multivitamínico en el estado nutricional y la anemia en niños en condición de vulnerabilidad social de Ciudad Juárez, Chihuahua. Métodos. Se realizó un estudio con enfoque cuantitativo, con diseño longitudinal analítico. Participaron 955 niños de una zona suburbana de 4-9 años (52.7% mujeres). La intervención consistió de un suplemento con Vitamina E, D y Omega 3. Se evaluaron variables antropométricas (peso, talla e IMC/edad) y se determinó la prevalencia de anemia antes y después de la intervención. Resultados. Se obtuvieron cambios significativos en los indicadores antropométricos y reducciones importantes en la prevalencia de desnutrición y anemia. Entre las mejoras antropométricas, el peso promedio aumentó de 23.7 a 25.1 kg, la talla de 118.2 a 119.8 cm y el percentil del IMC/edad, de 58.0 a 63.3 (P<0.05). La prevalencia de desnutrición de acuerdo al indicador de peso para la talla disminuyó de 18.7% a 16.9% en hombres (P<0.05). Por otro lado, la prevalencia de anemia pasó de 23.7% a 16.0% en mujeres (P<0.05) y del 33.2% al 16.0% en hombres (P<0.05). Conclusiones. El programa de intervención basado en un suplemento multivitamínico tuvo un impacto positivo en el estado nutricional de niños y en la anemia, destacando el potencial de las intervenciones basadas en suplementos multivitamínicos para mejorar la nutrición infantil en comunidades socialmente vulnerables. No obstante, se recomienda fortalecer la sostenibilidad de los programas e incluir estrategias complementarias para maximizar sus beneficios a largo plazo.

OBJECTIVE: The global epidemics of type 2 diabetes and obesity have been attributed to the interaction between lifestyle changes and genetic predisposition to these diseases. We compared the prevalences of type 2 diabetes and obesity in Mexican Pima Indians, presumed to have a high genetic predisposition to these diseases, to those in their non-Pima neighbors, both of whom over a 15-year period experienced a transition from a traditional to a more modern lifestyle. RESEARCH DESIGN AND METHODS: Prevalence of diabetes, impaired fasting glucose, impaired glucose tolerance, and obesity in Mexican Pimas (n = 359) and non-Pima Mexicans (n = 251) were determined in 2010 using methods identical to those used in 1995. RESULTS: During this 15-year period, age-adjusted diabetes prevalence was unchanged in Pima men (5.8% in 1995 vs. 6.1% in 2010) yet increased in non-Pima men from 0.0 to 8.6% (P < 0.05). Diabetes prevalence tended to increase in both Pima women (9.4 vs. 13.4%) and non-Pima women (4.8 vs. 9.5%). Age-adjusted prevalence of obesity increased significantly in all groups (6.6 vs. 15.7% in Pima men; 8.5 vs. 20.5% in non-Pima men; 18.9. vs 36.3% in Pima women; 29.5 vs. 42.9% in non-Pima women). CONCLUSIONS: Type 2 diabetes prevalence increased between 1995 and 2010 in non-Pima men, and to a lesser degree in women of both groups, but it did not increase in Pima men. Prevalence of obesity increased among Pimas and non-Pimas of both sexes. These changes occurred concomitantly with an environmental transition from a traditional to a more modernized lifestyle.

Exercise training performed at the maximal fat oxidation intensity (FMT) stands out as a potential treatment of overweight and obesity. This work is a meta-analysis of randomized clinical trials of studies about the effect of FMT on fat mass and maximal oxygen consumption using PubMed, SCOPUS, EBSCOhost, and ScienceDirect as databases. Two independent reviewers selected 11 trials from 356 publications identified by the following keywords: fatmax, lipoxmax, maximal fat oxidation, peak of fat oxidation, physical training, physical exercise, body fat (BF), fat mass, overweight, and obesity. The risk of bias was assessed following the Cochrane Guidelines. The pooled mean difference was computed for each outcome with the random-effects model and the inverse-variance method. The meta-analysis was performed with the RevMan software v 5.3, and the heterogeneity across studies by the I². The statistical significance was accepted at p < 0.05. Results showed that the FMT reduced body weight (MD = −4.30 kg, p < 0.01, I² = 0%), fat mass (MD = −4.03 kg, p < 0.01, I² = 0%), and waist circumference (MD = −3.34 cm, p < 0.01). Fat-free mass remains unchanged (MD = 0.08 kg, p = 0.85), but maximal oxygen consumption increased (MD = 2.96 mL∙kg⁻¹∙min⁻¹, p < 0.01, I² = 0%). We conclude that FMT at short and medium-term (eight to twenty weeks) reduces body weight and BF, increasing cardiovascular fitness in low physical fitness people with obesity.

A body mass index (BMI) ≥30 kg/m2 and a waist circumference (WC) ≥80 cm in women (WCF) or ≥90 cm in men (WCM) are reference cardiometabolic risk markers (CMM) for Mexicans adults. However, their reliability to predict other CMM (index tests) in young Mexicans has not been studied in depth. A cross-sectional descriptive study evaluating several anthropometric, physiological and biochemical CMM from 295 young Mexicans was performed. Sensitivity (Se), specificity (Sp) and Youden’s index (J) of reference BMI/WC cutoffs toward other CMM (n = 14) were obtained and their most reliable cutoffs were further calculated at Jmax. Prevalence, incidence and magnitude of most CMM increased along the BMI range (p < 0.01). BMI explained 81 % of WC’s variance [Se (97 %), Sp (71 %), J (68 %), Jmax (86 %), BMI = 30 kg/m2] and 4–50 % of other CMM. The five most prevalent (≥71 %) CMM in obese subjects were high WC, low HDL-C, and three insulin-related CMM [Fasting insulin, HOMA-IR, and QUICKI]. For a BMI = 30 kg/m2, J ranged from 16 % (HDL-C/LDL-C) to 68 % (WC), being moderately reliable (Jmax = 61–67) to predict high uric acid (UA), metabolic syndrome (MetS) and the hypertriglyceridemic-waist phenotype (HTGW). Corrected WCM/WCF were moderate-highly reliable (Jmax = 66–90) to predict HTGW, MetS, fasting glucose and UA. Most CMM were moderate-highly predicted at 27 ± 3 kg/m2 (CI 95 %, 25–28), 85 ± 5 cm (CI 95 %, 82–88) and 81 ± 6cm (CI 95 %, 75–87), for BMI, WCM and WCF, respectively. BMI and WC are good predictors of several CMM in the studied population, although at different cutoffs than current reference values.

Objective: To determine the prevalence of and modifiable factors associated with prediabetes in the Comcáac Indians.Design: Cross-sectional study where prediabetes was defined using fasting plasma glucose, 2 h plasma glucose and glycated Hb (HbA1c). Physical, anthropometric and biochemical measurements, medical record, socio-economic, dietary and physical activity information were collected. The modifiable factors associated with prediabetes were assessed using multiple logistic regression.Settings: Comcáac Indian communities of Punta Chueca and El Desemboque, Sonora, Mexico.Subjects: Adults (n227) aged 20 years or older.Results: The sex- and age-adjusted prevalence (95 % CI) of prediabetes was 47·1 (40·8, 53·5) % in the overall population; age-adjusted prevalence was 47·3 (35·6, 59·0) % in men and 46·7 (39·1, 54·3) % in women. The modifiable factors associated with a risk of prediabetes (OR; 95 % CI) were light-intensity physical activity (per 1 h/week increase: 1·04; 1·01, 1·07) and insulin resistance (homeostasis model assessment of insulin resistance score >6·1v. <4·1: 4·62; 1·37, 15·51). Increased consumption of a traditional dietary pattern based on fish and seafood, low-fat cereals, fruits and vegetables was a protective factor (0·49; 0·31, 0·79). All variables were modelled together and adjusted for age and sex.Conclusions: The high prediabetes prevalence found in the Comcáac community is alarming because it represents a large number of people who are at risk for type 2 diabetes. The identification of modifiable factors associated with prediabetes that are specific to this population may be useful for designing effective strategies to prevent prediabetes.