Background: To explore whether deep convolutional neural networks (DCNNs) have the potential to improve diagnostic efficiency and increase the level of interobserver agreement in the classification of thyroid nodules in histopathological slides. Methods: A total of 11,715 fragmented images from 806 patients’ original histological images were divided into a training dataset and a test dataset. Inception-ResNet-v2 and VGG-19 were trained using the training dataset and tested using the test dataset to determine the diagnostic efficiencies of different histologic types of thyroid nodules, including normal tissue, adenoma, nodular goiter, papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), medullary thyroid carcinoma (MTC) and anaplastic thyroid carcinoma (ATC). Misdiagnoses were further analyzed. Results: The total 11,715 fragmented images were divided into a training dataset and a test dataset for each pathology type at a ratio of 5:1. Using the test set, VGG-19 yielded a better average diagnostic accuracy than did Inception-ResNet-v2 (97.34% vs. 94.42%, respectively). The VGG-19 model applied to 7 pathology types showed a fragmentation accuracy of 88.33% for normal tissue, 98.57% for ATC, 98.89% for FTC, 100% for MTC, 97.77% for PTC, 100% for nodular goiter and 92.44% for adenoma. It achieved excellent diagnostic efficiencies for all the malignant types. Normal tissue and adenoma were the most challenging histological types to classify. Conclusions: The DCNN models, especially VGG-19, achieved satisfactory accuracies on the task of differentiating thyroid tumors by histopathology. Analysis of the misdiagnosed cases revealed that normal tissue and adenoma were the most challenging histological types for the DCNN to differentiate, while all the malignant classifications achieved excellent diagnostic efficiencies. The results indicate that DCNN models may have potential for facilitating histopathologic thyroid disease diagnosis.

Task-conditional architecture offers advantage in parameter efficiency but falls short in performance compared to state-of-the-art multi-decoder methods. How to trade off performance and model parameters is an important and difficult problem. In this paper, we introduce a simple and lightweight task-conditional model called Prompt Guided Transformer (PGT) to optimize this challenge. Our approach designs a Prompt-conditioned Transformer block, which incorporates task-specific prompts in the self-attention mechanism to achieve global dependency modeling and parameter-efficient feature adaptation across multiple tasks. This block is integrated into both the shared encoder and decoder, enhancing the capture of intra- and inter-task features. Moreover, we design a lightweight decoder to further reduce parameter usage, which accounts for only 2.7% of the total model parameters. Extensive experiments on two multi-task dense prediction benchmarks, PASCAL-Context and NYUD-v2, demonstrate that our approach achieves state-of-the-art results among task-conditional methods while using fewer parameters, and maintains a significant balance between performance and parameter size.