Background: This study aimed to develop a model that automatically predicts the neoadjuvant chemoradiotherapy (nCRT) response for patients with locally advanced cervical cancer (LACC) based on T2-weighted MR images and clinical parameters. Methods: A total of 138 patients were enrolled, and T2-weighted MR images and clinical information of the patients before treatment were collected. Clinical information included age, stage, pathological type, squamous cell carcinoma (SCC) level, and lymph node status. A hybrid model extracted the domain-specific features from the computational radiomics system, the abstract features from the deep learning network, and the clinical parameters. Then, it employed an ensemble learning classifier weighted by logistic regression (LR) classifier, support vector machine (SVM) classifier, K-Nearest Neighbor (KNN) classifier, and Bayesian classifier to predict the pathologic complete response (pCR). The area under the receiver operating characteristics curve (AUC), accuracy (ACC), true positive rate (TPR), true negative rate (TNR), and precision were used as evaluation metrics. Results: Among the 138 LACC patients, 74 were in the pCR group, and 64 were in the non-pCR group. There was no significant difference between the two cohorts in terms of tumor diameter (p = 0.787), lymph node (p = 0.068), and stage before radiotherapy (p = 0.846), respectively. The 109-dimension domain features and 1472-dimension abstract features from MRI images were used to form a hybrid model. The average AUC, ACC, TPR, TNR, and precision of the proposed hybrid model were about 0.80, 0.71, 0.75, 0.66, and 0.71, while the AUC values of using clinical parameters, domain-specific features, and abstract features alone were 0.61, 0.67 and 0.76, respectively. The AUC value of the model without an ensemble learning classifier was 0.76. Conclusions: The proposed hybrid model can predict the radiotherapy response of patients with LACC, which might help radiation oncologists create personalized treatment plans for patients.

Similar to the basic facial expression recognition, one challenge for pain intensity recognition is some individual characteristics, e.g. face shapes, may cause great diversities in the same emotion. So it is usually very difficult to distinguish two adjacent intensity levels of pain expression as each intensity has a large variation. In this study, a coarse‐to‐fine combination method is proposed for pain intensity recognition. The results of multi‐scale outputs from multiple base deep network are combined in a probabilistic way for improving the discrimination between visually similar adjacent levels. A two‐layer tree classifier is proposed in a multi‐task framework for pain intensity recognition as well as face shape recognition, replacing the planar Softmax classifier in each base deep network. In the first layer of tree classifier, multi‐scale classifiers are constructed for recognizing facial pain intensities and the conventional classifiers are constructed for face shape recognition in the second layer. Finally, the tree classifier including multi‐scale classifiers and conventional classifiers is jointly optimised during the training phase and only high level classifiers are used for recognising pain intensities in the test phase. The extensive experiments on UNBC shoulder pain dataset show the proposed method gets promising results in pain intensity recognition.

Pain is a common treatment response of patients in clinical medicine, which indicates the patient’s status. Of late, automatic pain estimation methods have received more and more attention due to their convenience and objectivity. However, the previous researches mostly employ existing models or frameworks, without the exploration of pain locality. In this paper, we propose Multi-Scale Regional Attention Networks (MSRAN), to adaptively capture the importance of facial pain regions. Specifically, the proposed MSRAN aggregates and embeds varied number of multi-scale region features by a convolutional neural network with self-attention module for the locality of pain. Then, the proposed relation-attention module is leveraged to explore the relationship of pain regions. Last, the well-designed loss function is employed to increase the discrimination of model. We validate our MSRAN on the public pain dataset, which shows the effectiveness of the proposed method.

Pain is a common phenomenon in clinical patients, which indicates patients are suffering from uncomfortable conditions for necessary treatments. So the assessment of pain status becomes a significant task in current medical institutions. Of late, various conventional hand‐crafted or deep learning methods on face images are presented to estimate pain intensity automatically. However, these approaches usually feed the whole face into the automatic estimation system and explore little information on the interdependencies of related regions during the formation of pain expression. In this paper, a hierarchical deep network (HDN) involving regional and holistic information simultaneously is proposed via two scale branches. In HDN, a region‐wise branch is designed to extract features from pain related regions of face images while a global‐wise branch explores the interdependencies of pain related regions. Besides, in global‐wise branch, a multi‐task learning method is employed to detect action units while estimating pain intensity. Finally, the pain estimation outputs of two branches are fused in a decision level. On current pain estimation benchmarks, it is empirically shown that the proposed HDN outperforms the existing methods and the essential components in HDN have key influences on final prediction.

Deep networks have shown strong performance in glioma grading; however, interpreting their decisions remains challenging due to glioma heterogeneity. To address these challenges, the proposed solution is the Causal Segmentation Framework (CSF). This framework aims to accurately predict high- and low-grade gliomas while simultaneously highlighting key subregions. Our framework utilizes a shrinkage segmentation method to identify subregions containing essential decision information. Moreover, we introduce a glioma grading module that combines deep learning and traditional approaches for precise grading. Our proposed model achieves the best performance among all models, with an AUC of 96.14%, an F1 score of 93.74%, an accuracy of 91.04%, a sensitivity of 91.83%, and a specificity of 88.88%. Additionally, our model exhibits efficient resource utilization, completing predictions within 2.31s and occupying only 0.12 GB of memory during the test phase. Furthermore, our approach provides clear and specific visualizations of key subregions, surpassing other methods in terms of interpretability. In conclusion, the Causal Segmentation Framework (CSF) demonstrates its effectiveness at accurately predicting glioma grades and identifying key subregions. The inclusion of causality in the CSF model enhances the reliability and accuracy of preoperative decision-making for gliomas. The interpretable results provided by the CSF model can assist clinicians in their assessment and treatment planning.