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Febrile seizure (FS) is the most prevalent childhood seizure; it is significantly related to subsequent epilepsy and has possible links to childhood neurodevelopmental disorders. Separately, premature births are believed to increase the risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Therefore, this study investigated whether preterm birth is a risk factor for subsequent epilepsy, ASD, and ADHD in children with FS. We retrospectively collected data for children aged < 5 years with FS from 1 January 2005, to 31 December 2013. We divided these children into two groups—the premature birth group and the full-term group—and compared their incidence rates of epilepsy, ASD and ADHD. The data of 426 patients with history of febrile convulsion were retrospectively collected. The premature birth group (FS+/preterm+) had 108 patients and the full-term group (FS+/preterm−) had 318 patients. The overall epilepsy risk in the FS+/preterm+ group was higher than in the FS+/preterm− group (odds ratio [OR], 2.52; 95% confidence interval [CI], 1.14–5.58; p = 0.02). The overall risk of ADHD in the FS+/preterm+ group was higher than that in the FS+/preterm− group (OR, 6.41; 95% CI, 3.39–12.09; p = 0.0001). In addition, children with FS+/preterm+ had 16.9 times (95% CI, 4.79–59.7; p = 0.0001) higher odds of having ASD compared with those with FS+/preterm−. Preterm birth may be a risk factor for subsequent epilepsy, ASD and ADHD in children with FS.
Chien-Heng Lin; Wei-De Lin; I-Ching Chou; Inn-Chi Lee; Syuan-Yu Hong. Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study. Life 2021, 11, 854 .
AMA StyleChien-Heng Lin, Wei-De Lin, I-Ching Chou, Inn-Chi Lee, Syuan-Yu Hong. Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study. Life. 2021; 11 (8):854.
Chicago/Turabian StyleChien-Heng Lin; Wei-De Lin; I-Ching Chou; Inn-Chi Lee; Syuan-Yu Hong. 2021. "Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study." Life 11, no. 8: 854.
Background: Pediatric epileptic encephalopathy and severe neurological disorders comprise a group of heterogenous diseases. We used whole-exome sequencing (WES) to identify genetic defects in pediatric patients. Methods: Patients with refractory seizures using ≥2 antiepileptic drugs (AEDs) receiving one AED and having neurodevelopmental regression or having severe neurological or neuromuscular disorders with unidentified causes were enrolled, of which 54 patients fulfilled the inclusion criteria, were enrolled, and underwent WES. Results: Genetic diagnoses were confirmed in 24 patients. In the seizure group, KCNQ2, SCN1A, TBCID 24, GRIN1, IRF2BPL, MECP2, OSGEP, PACS1, PIGA, PPP1CB, SMARCA4, SUOX, SZT2, UBE3A, 16p13.11 microdeletion, [4p16.3p16.1(68,345–7,739,782)X1, 17q25.1q25.3(73,608,322–81,041,938)X3], and LAMA2 were identified. In the nonseizure group, SCN2A, SPTBN2, DMD, and FBN1 were identified. Ten novel mutations were identified. The recurrent genes included SCN1A, KCNQ2, and TBCID24. Male pediatric patients had a significantly higher (57% vs. 29%; p < 0.05, odds ratio = 3.18) yield than their female counterparts. Seventeen genes were identified from the seizure groups, of which 82% were rare genetic etiologies for childhood seizure and did not appear recurrently in the case series. Conclusions: Wide genetic variation was identified for severe childhood seizures by WES. WES had a high yield, particularly in male infantile patients.
Syuan-Yu Hong; Jiann-Jou Yang; Shuan-Yow Li; Inn-Chi Lee. A Wide Spectrum of Genetic Disorders Causing Severe Childhood Epilepsy in Taiwan: A Case Series of Ultrarare Genetic Cause and Novel Mutation Analysis in a Pilot Study. Journal of Personalized Medicine 2020, 10, 281 .
AMA StyleSyuan-Yu Hong, Jiann-Jou Yang, Shuan-Yow Li, Inn-Chi Lee. A Wide Spectrum of Genetic Disorders Causing Severe Childhood Epilepsy in Taiwan: A Case Series of Ultrarare Genetic Cause and Novel Mutation Analysis in a Pilot Study. Journal of Personalized Medicine. 2020; 10 (4):281.
Chicago/Turabian StyleSyuan-Yu Hong; Jiann-Jou Yang; Shuan-Yow Li; Inn-Chi Lee. 2020. "A Wide Spectrum of Genetic Disorders Causing Severe Childhood Epilepsy in Taiwan: A Case Series of Ultrarare Genetic Cause and Novel Mutation Analysis in a Pilot Study." Journal of Personalized Medicine 10, no. 4: 281.
Although studies have suggested environmental factors to be triggers of headache, the contribution of long-term air pollution exposure to recurrent headaches is poorly understood. Hence, we executed this nationwide cohort study to investigate associations between levels of ambient air pollutants and risks of recurrent headaches in children in Taiwan from 2000 to 2012. We used data from the Taiwan National Health Insurance Research Database and linked them to the Taiwan Air Quality Monitoring Database. Overall, 218,008 children aged < 18 were identified from 1 January 2000, and then followed until they were diagnosed by a physician for ≥3 times with recurrent headaches or until 31 December 2012. We categorized the annual average concentration of each air pollutant (fine particulate matter, total hydrocarbon, methane, sulfur dioxide, and nitrogen dioxide) into quartiles (Q1–Q4). We measured the incidence rate, hazard ratios (HRs), and the corresponding 95% confidence intervals for recurrent headaches. stratified by the quartiles. A total of 28,037 children (12.9%) were identified with recurrent headaches. The incidence rate and adjusted HR for recurrent headaches increased with higher-level exposure of air pollutants, except sulfur dioxide. We herein demonstrate that long-term ambient air pollutant exposure might be a risk factor for childhood recurrent headaches.
Syuan-Yu Hong; Lei Wan; Hui-Ju Lin; Cheng-Li Lin; Chang-Ching Wei. Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study. International Journal of Environmental Research and Public Health 2020, 17, 9140 .
AMA StyleSyuan-Yu Hong, Lei Wan, Hui-Ju Lin, Cheng-Li Lin, Chang-Ching Wei. Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study. International Journal of Environmental Research and Public Health. 2020; 17 (23):9140.
Chicago/Turabian StyleSyuan-Yu Hong; Lei Wan; Hui-Ju Lin; Cheng-Li Lin; Chang-Ching Wei. 2020. "Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study." International Journal of Environmental Research and Public Health 17, no. 23: 9140.
This paper highlights the highly transmitted features of PIGA and other X-linked EIEEs, raising awareness of rare forms of epileptic encephalopathy.
Wei-De Lin; I-Ching Chou; Fuu-Jen Tsai; Syuan-Yu Hong. A novel PIGA mutation in a Taiwanese family with early-onset epileptic encephalopathy. Seizure 2018, 58, 52 -54.
AMA StyleWei-De Lin, I-Ching Chou, Fuu-Jen Tsai, Syuan-Yu Hong. A novel PIGA mutation in a Taiwanese family with early-onset epileptic encephalopathy. Seizure. 2018; 58 ():52-54.
Chicago/Turabian StyleWei-De Lin; I-Ching Chou; Fuu-Jen Tsai; Syuan-Yu Hong. 2018. "A novel PIGA mutation in a Taiwanese family with early-onset epileptic encephalopathy." Seizure 58, no. : 52-54.