Seismically induced soil liquefaction has been documented after the M7.8, 2016 Pedernales earthquake. In the city of Jama, the acceleration recorded by soil amplification yielded 1.05 g with an intensity of VIII to IX_ESI-07. The current study combines geological, geophysical, and geotechnical data in order to establish a geological characterization of the subsoil of the city of Jama in the Manabi province of Ecuador. Then, the liquefaction potential index (LPI) has been evaluated considering the PGA-rock values calculated from deterministic methods applied to nearby geological faults, as well as the soil acceleration records for the city of Jama since the Pedernales megathrust earthquake. The importance of conducting geotechnical evaluations of particular colluvial, alluvial, and floodplain deposits, for which the liquefaction probability profiles have been additionally obtained, may serve as a useful tool for edifices foundations or earthquake resistant designs. Finally, the site response analysis is presented using a linear equivalent analysis, where previously seismic records compatible with the target spectrum have been selected. Hereby, the results of ground surface effects have been compared with the spectra of the Ecuadorian Regulation of Construction (NEC) in the context of local seismic amplification.