The application of reinforced concrete (RC) beam with near-surface mounted (NSM) pre-stressed carbon fiber reinforced polymer (CFRP) plates has been increasingly widespread in civil engineering. However, debonding failure occurs easily in the early loading stage because of the prestress change at the end of CFRP plate. Therefore, it is important to find reliable, convenient and economical technical means to closely monitor the secure bonding between CFRP and concrete. In this paper, an active sensing approach for generating and sensing stress wave by embedded smart aggregates (SAs) is proposed, which provides a guarantee for the secure connection between CFRP and concrete. Two specimens with different non-pre-stressed bond lengths were fabricated in the laboratory. Six SAs were installed at different positions of the structure to monitor the degree of debonding damage during the loading process. The experiments showed that the optimal length of non-pre-stressed CFRP bond section (300 mm) can significantly improve the load characteristics and enhance the service performance of the structure. The theoretical analysis of wavelet packet shows that increasing the length of non-pre-stressed CFRP bond section can slow down the occurrence and propagation of debonding cracks. The debonding crack in the tension end region is earlier than that in the bond end region. The research results reflect that the developed approach can monitor the damage process caused by debonding cracks and provide early warning for the initial damage and the debonding failure.