Carbohydrate consumption during pregnancy represents an important source of energy; its consumption, however, can cause gestational diabetes mellitus (GDM), body weight gain, inflammation, increased glucose transport to the fetus, adiposity, and a risk of macrosomia. The objective was to research the impact of sucrose consumption during pregnancy on the metabolic, immune, and redox profile in female mice with GDM. A total of 24 female CD1 mice were used, divided into two groups: Control and GDM. Each group was subdivided into two subgroups: (a) Without sucrose and (b) With sucrose. The females were mated, and, once pregnancy was confirmed, GDM was induced by administering 230 mg/kg of streptozotocin subcutaneously. GDM was confirmed by glucose ≥ 200 mg/dL and the presence of polyphagia, polydipsia, and change in body weight. Metabolic, immune, and redox profile parameters were determined. Sucrose consumption groups increase HOMA-IR and the secretion of insulin, adiponectin, and leptin; it also increased the secretion of proinflammatory cytokines and the production of IgA and IgG antibodies, decreased the activity of the Glutathione Reductase enzyme, and increased the production of TBARS and AGE. High sucrose consumption increases the inflammatory response mediated mainly by CD8⁺ lymphocytes and the production of proinflammatory cytokines; it can trigger a compensatory humoral response and alter redox mechanisms, causing a state of Oxidant Stress.

Aim: This study aims to analyze the impact of sucrose consumption on inflammatory and immunological parameters of newborn offspring of females with gestational diabetes mellitus (GDM). Methods: 4 groups of pregnant female CD1 mice were created (n = 6): A, without GDM, without sucrose supplementation; B, without GDM, with sucrose supplementation; C, with GDM, without sucrose supplementation; and D, with GDM, with sucrose supplementation. GDM was induced by subcutaneous injection of streptozotocin, with a dose of 230 mg/kg. Sucrose supplementation was administered at a concentration of 41.66 mg/mL per oral stool (500 μL volume) to each female daily at 8:00 am from confirmation of gestational diabetes until the end of pregnancy. Immediately after birth, the pups were sacrificed in the first 2 h of life. The following were quantified in each group of 8 newborns: body weight, glycaemia, leptin, adiponectin, insulin, HOMA-IR index, percentage of lymphocytes: CD3, CD4, and CD8, immunoglobulins (IgA and IgG), cytokines (IL-1β, IL-6, TNF-α, and IFN-γ), and redox activity: (carbonylated proteins, malondialdehyde, superoxide dismutase, catalase, reduced glutathione, total antioxidant capacity). Results: Sucrose consumption increased the levels of adiponectin, IL-1β, IL-6 and decreased the concentration of IgA in the offspring. Group C and D caused lower body weight and higher concentration of carbonylated proteins. The combination of sucrose and GDM favored an increase in blood glucose, the HOMA-IR index, the percentage of T lymphocytes, the concentration of proinflammatory cytokines, and reduced glutathione, with reduction of catalase. Conclusions: Sucrose consumption by mothers during pregnancy and the presence of GDM generate alterations at the cellular, immunological, metabolic, hormonal, and redox levels in newborns. This results in an inflammatory state, with an imbalance in the redox state, which predisposes the newborn to short and medium-term metabolic problems from birth.

The objective is to investigate how carefully designed auditory stimuli—such as soundscapes, soft melodies, or interactive sounds—can create more friendly and emotionally safe environments for hospitalized pediatric patients. This is because noise pollution in hospitals, which refers to excessive sound that disrupts normal work conditions—in this case, hospital stays—can cause health problems, such as stress, headaches, anxiety, sleep disorders, and others. This topic is studied because it is believed that design should focus not only on aesthetics but also on functionality and humanity. In pediatric hospitals, many patients experience fear, anxiety, insomnia, and stress during their treatments. Using sound as a therapeutic channel can transform their hospital stay, helping them navigate their medical processes with greater emotional well-being. It's a way to contribute through digital and sound design to a cause with a high social and emotional impact. This work seeks to suggest alternatives from the perspective of sound design and qualitative data from real patients and their companions, transforming the system into a real, useful, and beyond-the-box therapeutic resource. Its goal is to be applied in hospital settings and serve as a basis for future research and development in the field of design applied to children's health.

El síndrome del cuidador son aquellas personas que sufren el desgaste físico, psicológico y de su salud en general en el cuidado constante y continuado del enfermo. El presente estudio tuvo como objetivo identificar el síndrome del cuidador y el diagnóstico nutricional del cuidador primario de pacientes con TDAH, mediante la aplicación de la escala de sobrecarga de Zarit y el diagnóstico nutricional. Los resultados muestran que el 42% de los participantes tienen sobrecarga leve y el 70% de los participantes presentan sobrepeso. Se requiere de un análisis más detallado en estos pacientes, ya que, los padres y encargados de aula de los niños con TDAH tienen cargas diferentes al momento de responsabilizarse del menor. Así también, es importante considerar el contexto en el que se encuentra cada paciente. Este primer acercamiento a los cuidadores de pacientes con TDAH permitirá darle visibilidad a un síndrome que cada vez es más recurrente en personas a cargo de un paciente con algún padecimiento crónico de cualquier índole.

Carbohydrate consumption during pregnancy represents an important source of energy for the mother-child duo; its consumption, however, can cause gestational diabetes mellitus (GDM), body weight gain, inflammation, increases glucose transport to the fetus, adiposity and the risk of macrosomia. The objective was to research the impact of sucrose consumption during pregnancy on the metabolic, immune and Redox profile in females with GDM. 24 female CD1 mice were used, they were divided into two groups: Control and DMG. Each group was subdivided into 2 subgroups: a) Without Sucrose and b) With Sucrose. The following were determined: Body Mass Index (BMI), Glycaemia, hormones (insulin, adiponectin and leptin), CD3+ T lymphocytes, cytokines (IL-1β, IL-6, IFN-γ and TNF-α), IgA and IgG antibodies, as well as Redox systems. The Sucrose consumption increases HOMA-IR and the secretion of insulin, adiponectin and leptin, it also increased the secretion of proinflammatory cytokines and the production of IgA and IgG antibodies, decreased the activity of the Glutathione Reductase enzyme and increased the production of TBARS and AGE. High sucrose consumption increases the inflammatory response mediated mainly by CD8+ lymphocytes and the production of proinflammatory cytokines, it can trigger a compensatory humoral response and alter Redox mechanisms causing a state of Oxidant Stress.