(1) Background: Our aim is to reveal the influence of the geometry designs on biophysical stimuli and healing patterns. The design guidelines for dental implants can then be provided. (2) Methods: A two-dimensional axisymmetric finite element model was developed based on mechano-regulatory algorithm. The history of tissue differentiation around eight selected implants can be predicted. The performance of the implants was evaluated by bone area (BA), bone-implant contact (BIC); (3) Results: The predicted healing patterns have very good agreement with the experimental observation. Many features observed in literature, such as soft tissues covering on the bone-implant interface; crestal bone loss; the location of bone resorption bumps, were reproduced by the model and explained by analyzing the solid and fluid biophysical stimuli and (4) Conclusions: The results suggested the suitable depth, the steeper slope of the upper flanks, and flat roots of healing chambers can improve the bone ingrowth and osseointegration. The mechanism related to solid and fluid biophysical stimuli were revealed. In addition, the model developed here is efficient, accurate and ready to extend to any geometry of dental implants. It has potential to be used as a clinical application for instant prediction/evaluation of the performance of dental implants.

Replacing missing teeth with implant-supported prostheses is a common practice; however, function-induced early bone loss may exacerbate peri-implantitis. Identifying factors that influence marginal bone loss is crucial. This study used finite element (FE) simulation and in-vitro analysis to evaluate design concepts and their effects on stresses and strains in dental implants and surrounding bone. Five implant designs were analyzed: (1) full solid, (2) upper porous, (3) lower porous, (4) lower porous: upper half, and (5) lower porous: lower half. The study included stability measurements, three-dimensional FE modeling, in-vitro mechanical testing, and simulations of long-term bone remodeling. The full-solid design showed the highest stress tolerance, followed by the lower porous and upper porous designs. Stress concentration was higher with oblique forces. The upper porous design favored bone strain distribution but exhibited permanent deformation beyond 350 N. Lower porous implants demonstrated similar strength to the full solid but superior marginal bone growth. Within the scope of this study, the following conclusions were drawn: (1) A well-designed porous structure enhances post-implantation bone growth; (2) An upper porous design facilitates bone ingrowth but exhibits reduced strength under stress; (3) Lowering porosity adversely affects bone regeneration.