Aims: Evaluating expression of the human epidermal growth factor receptor 2 (HER2) by visual examination of immunohistochemistry (IHC) on invasive breast cancer (BCa) is a key part of the diagnostic assessment of BCa due to its recognized importance as a predictive and prognostic marker in clinical practice. However, visual scoring of HER2 is subjective, and consequently prone to interobserver variability. Given the prognostic and therapeutic implications of HER2 scoring, a more objective method is required. In this paper, we report on a recent automated HER2 scoring contest, held in conjunction with the annual PathSoc meeting held in Nottingham in June 2016, aimed at systematically comparing and advancing the state‐of‐the‐art artificial intelligence (AI)‐based automated methods for HER2 scoring.Methods and results: The contest data set comprised digitized whole slide images (WSI) of sections from 86 cases of invasive breast carcinoma stained with both haematoxylin and eosin (H&E) and IHC for HER2. The contesting algorithms predicted scores of the IHC slides automatically for an unseen subset of the data set and the predicted scores were compared with the ‘ground truth’ (a consensus score from at least two experts). We also report on a simple ‘Man versus Machine’ contest for the scoring of HER2 and show that the automated methods could beat the pathology experts on this contest data set.Conclusions: This paper presents a benchmark for comparing the performance of automated algorithms for scoring of HER2. It also demonstrates the enormous potential of automated algorithms in assisting the pathologist with objective IHC scoring.

The erratic modern world introduces challenges to all sectors of societies and potentially introduces additional inequality. One possibility to decrease the educational inequality is to provide remote access to facilities that enable learning and training. A similar approach of remote resource usage can be utilized in resource-poor situations where the required equipment is available at other premises. The concept of Industry 5.0 (i5.0) focuses on a human-centric approach, enabling technologies to concentrate on human–machine interaction and emphasizing the importance of societal values. This paper introduces a novel robotics teleoperation platform supported by the i5.0. The platform reduces inequality and allows usage and learning of robotics remotely independently of time and location. The platform is based on digital twins with bi-directional data transmission between the physical and digital counterparts. The proposed system allows teleoperation, remote programming, and near real-time monitoring of controlled robots, robot time scheduling, and social interaction between users. The system design and implementation are described in detail, followed by experimental results.

Digital technology has evolved towards a new way of processing information: web searches, social platforms, internet forums, and video games have substituted reading books and writing essays. Trainers and educators currently face the challenge of providing natural training and learning environments for digital-natives. In addition to physical spaces, effective training and education require virtual spaces. Digital twins enable trainees to interact with real hardware in virtual training environments. Interactive real-world elements are essential in the training of robot operators. A natural environment for the trainee supports an interesting learning experience while including enough professional substances. We present examples of how virtual environments utilizing digital twins and extended reality can be applied to enable natural and effective robotic training scenarios. Scenarios are validated using cross-platform client devices for extended reality implementations and safety training applications.

Digitalization shapes the ways of learning, working, and entertainment. The Internet, which enables us to connect and socialize is evolving to become the metaverse, a post-reality universe, enabling virtual life parallel to reality. In addition to gaming and entertainment, industry and academia have noticed the metaverse’s benefits and possibilities. For industry, the metaverse is the enabler of the future digital workplace, and for academia, digital learning spaces enable realistic virtual training environments. A connection bridging the virtual world with physical production systems is required to enable digital workplaces and digital learning spaces. In this publication, extended reality–digital twin to real use cases are presented. The presented use cases utilize extended reality as high-level user interfaces and digital twins to create a bridge between virtual environments and robotic systems in industry, academia, and underwater exploration.

In this paper, we address the most pressing challenges faced by the manufacturing sector, particularly the manufacturing of small and medium-sized enterprises (SMEs), where the transition towards high-mix low-volume production and the availability of cost-effective solutions are crucial. To overcome these challenges, this paper presents 14 innovative solutions that can be utilized to support the introduction of agile manufacturing processes in SMEs. These solutions encompass a wide range of key technologies, including reconfigurable fixtures, low-cost automation for printed circuit board (PCB) assembly, computer-vision-based control, wireless sensor networks (WSNs) simulations, predictive maintenance based on Internet of Things (IoT), virtualization for operator training, intuitive robot programming using virtual reality (VR), autonomous trajectory generation, programming by demonstration for force-based tasks, on-line task allocation in human–robot collaboration (HRC), projector-based graphical user interface (GUI) for HRC, human safety in collaborative work cells, and integration of automated ground vehicles for intralogistics. All of these solutions were designed with the purpose of increasing agility in the manufacturing sector. They are designed to enable flexible and modular manufacturing systems that are easy to integrate and use while remaining cost-effective for SMEs. As such, they have a high potential to be implemented in the manufacturing industry. They can be used as standalone modules or combined to solve a more complicated task, and contribute to enhancing the agility, efficiency, and competitiveness of manufacturing companies. With their application tested in industrially relevant environments, the proposed solutions strive to ensure practical implementation and real-world impact. While this paper presents these solutions and gives an overview of their methodologies and evaluations, it does not go into their details. It provides summaries of comprehensive and multifaceted solutions to tackle the evolving needs and demands of the manufacturing sector, empowering SMEs to thrive in a dynamic and competitive market landscape.