The axle box bearing of bogie is one of the key components of the rail transit train, which can ensure the rotary motion of wheelsets and make the wheelsets adapt to the conditions of uneven railways. At the same time, the axle box bearing also exposes most of the load of the car body. Long-time high-speed rotation and heavy load make the axle box bearing prone to failure. If the bearing failure occurs, it will greatly affect the safety of the train. Therefore, it is extremely important to monitor the health status of the axle box bearing. At present, the health status of the axle box bearing is mainly monitored by vibration information and temperature information. Compared with the temperature data, the vibration data can more easily detect the early fault of the bearing, and early warning of the bearing state can avoid the occurrence of serious fault in time. Therefore, this paper is based on the vibration data of the axle box bearing to carry out adaptive fault diagnosis of bearing. First, the AR model predictive filter is used to denoise the vibration signal of the bearing, and then the signal is whitened in the frequency domain. Finally, the characteristic value of vibration data is extracted by energy operator demodulation, and the fault type is determined by comparing with the theoretical value. Through the analysis of the constructed simulation signal data, the characteristic parameters of the data can be effectively extracted. The experimental data collected from the bearing testbed of high-speed train are analyzed and verified, which further proves the effectiveness of the feature extraction method proposed in this paper. Compared with other axle box bearing fault diagnosis methods, the innovation of the proposed method is that the signal is denoised twice by using AR filter and spectrum whitening, and the adaptive extraction of fault features is realized by using energy operator. At the same time, the steps of setting parameters in the process of feature extraction are avoided in other feature extraction methods, which improves the diagnostic efficiency and is conducive to use in online monitoring system.

An axle box bearing is one of the most important components of high-speed EMUs (electric multiple units), which runs at a very fast speed, suffers a heavy load, and operates under various complex working conditions. Once a bearing fault occurs, it not only has an enormous impact on the railway system, but also poses a threat to personal safety. Therefore, there is significant value in studying a real-time fault early warning of a high-speed EMU axle box bearing. However, to our best knowledge, there are three obvious defects in the existing fault early warning methods used for high-speed EMU axle box bearings: (1) these methods based on vibration are extremely mature, but there are no vibration sensors installed in high-speed EMU axle box because it will greatly increase the manufacturing cost; (2) a TADS (trackside acoustic device system) can effectively detect early failures, but only a portion of railways are equipped with such a facility; and (3) an EMU-ODS (electric multiple unit onboard detection system) has reported numerous untimely warnings, along with warnings of frequent occurrence being missed. Whereupon, a method is proposed to realize the fault early warning of an axle box bearing without installing a vibration sensor on the high-speed EMU in service, namely a MLSTM-iForest (multilayer long short-term memory–isolation forest). First, the time-series data of the temperature-related variables of the axle box bearing is used as the input of MLSTM to predict the axle box bearing temperature in the future. Then, the deviation index of the predicted axle box bearing temperature is calculated. Finally, the deviation index is input into an iForest algorithm for unsupervised classification to realize the fault early warning of an axle box bearing. Experimental results on high-speed EMU operation data sets demonstrated the availability and feasibility of the presented method toward achieving early fault warnings of a high-speed EMU axle box bearing.

Bearings are key components of modern mechanical equipment. To address the issue that the limited information contained in the single-source signal of the bearing leads to the limited accuracy of the single-source fault diagnosis method, a multi-sensor fusion fault diagnosis method is proposed to improve the reliability of bearing fault diagnosis. Firstly, the feature extraction process of the convolutional neural network (CNN) is improved based on the theory of variational Bayesian inference, which forms the variational Bayesian inference convolutional neural network (VBICNN). VBICNN is used to obtain preliminary diagnosis results of single-channel signals. Secondly, considering the redundancy of information contained in multi-channel signals, a voting strategy is used to fuse the preliminary diagnosis results of the single-channel model to obtain the final results. Finally, the proposed method is evaluated by an experimental dataset of the axlebox bearing of a high-speed train. The results show that the average diagnosis accuracy of the proposed method can reach more than 99% and has favorable stability.

Background: Endothelial-mesenchymal transition (EndMT) is an important process of angiogenesis, which plays a significant role in in tumor invasion and metastasis, while its regulatory mechanisms in breast cancer remain to be fully elucidated. We previously demonstrated that tumor-associated macrophages (TAMs) can induce EndMT in endothelial cells by secreting CCL18 through the activation of the TGF-β and Notch signaling pathways in breast cancer. This study was designed to study the role of EndMT in breast cancer angiogenesis and progression in order to explore the underlying mechanism.Methods: Immunohistochemistry (IHC) was used to evaluate the expression of microvascular density (MVD) and EndMT markers in breast cancer. TGF-β1 was used to induce EndMT models of differentiated-endothelial breast cancer stem-like cells (BCSLCs). In vitro cell migration, proliferation and matrigel tube-formation assays, as well as in vivo nude mouse tumor-bearing model and nude mouse dorsal skinfold window chamber (DSWC) model, were utilized to investigate the effects in order to explore the mechanism of EndMT induced by TGF-β1 on breast cancer progression.Results: In this study, we demonstrated that the EndMT markers were positively associated with MVD indicating unfavorable prognosis of invasive ductal carcinoma (IDC) patients. Functionally, TGF-β1 promoted migration, proliferation and angiogenesis of differentiated-endothelial BCSLCs by inducing EndMT in vitro and promoted tumor growth and angiogenesis in vivo. Mechanically, we revealed TGF-β1 induced EndMT by activation of TGF-β and Notch signaling pathways with increase of p-Smad2/3 and Notch1 expression. Moreover, we found Snail and Slug were key factors of TGF-β and Notch signaling pathways.Conclusion: Our findings elucidated the mechanism of TGF-β1 in the promotion of angiogenesis and progression by EndMT in breast cancer.

Bearings of rail vehicles bear various dynamic forces. Any fault of the bearing seriously threatens running safety. For fault diagnosis, vibration and temperature measured from the bogie and acoustic signals measured from trackside are often used. However, installing additional sensing devices on the bogie increases manufacturing cost while trackside monitoring is susceptible to ambient noise. For other application, structural displacement based on computer vision is widely applied for deflection measurement and damage identification of bridges. This article proposes to monitor the health condition of the rail vehicle bearings by detecting the displacement of bolts on the end cap of the bearing box. This study is performed based on an experimental platform of bearing systems. The displacement is monitored by computer vision, which can image real-time displacement of the bolts. The health condition of bearings is reflected by the amplitude of the detected displacement by phase correlation method which is separately studied by simulation. To improve the calculation rate, the computer vision only locally focuses on three bolts rather than the whole image. The displacement amplitudes of the bearing system in the vertical direction are derived by comparing the correlations of the image’s gray-level co-occurrence matrix (GLCM). For verification, the measured displacement is checked against the measurement from laser displacement sensors, which shows that the displacement accuracy is 0.05 mm while improving calculation rate by 68%. This study also found that the displacement of the bearing system increases with the increase in rotational speed while decreasing with static load.